The physical ability of elderly female Japanese patients with cerebrovascular disease correlates with telomere length in their peripheral blood leukocytes

Toyoki Maeda, Jun Ichi Oyama, Makoto Sasaki, Yasuhiro Nishiyama, Yoshihiro Kudo, Tomoko Yamori, Takashi Nakazono, Takahiro Arima, Naoki Makino

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background and aims: The telomere length of peripheral blood leukocytes has been reported to be inversely correlated with many kinds of pathophysiological conditions. However, correlations between telomere length in peripheral blood leukocytes and patients' physical ability are not known. Methods: To address this problem, the physical ability of patients with cerebrovascular disease admitted to the chronic disease ward of Kyushu University Hospital was assessed with the Barthel index (BI) and the telomere length of their peripheral blood leukocytes was determined. Results and conclusions: Women exhibited a significant correlation between the Barthel score and the expression of long telomeres (>9.4 Kb), in contrast with men who revealed no such correlation. The physical ability of older women was positively correlated with the lengths of their somatic telomeres. Among the BI items, the scores of more difficult physical performances tended to correlate with the presence of terminal restriction fragments longer than 9.4 Kb.

Original languageEnglish
Pages (from-to)22-28
Number of pages7
JournalAging Clinical and Experimental Research
Volume23
Issue number1
DOIs
Publication statusPublished - Feb 2011

    Fingerprint

All Science Journal Classification (ASJC) codes

  • Ageing
  • Geriatrics and Gerontology

Cite this