Abstract
The Y-box-binding protein (YB-1) represents the most evolutionary conserved nucleic-acid-binding protein currently known. YB-1 is a member of the cold-shock domain (CSD) protein superfamily. It performs a wide variety of cellular functions, including transcriptional regulation, translational regulation, DNA repair, drug resistance and stress responses to extracellular signals. As a result, YB-1 expression is closely associated with cell proliferation. In this review, we will begin by briefly describing the characteristics of YB-1 and will then summarize the pleiotropic functions brought about via DNA-RNA transaction and protein-protein interactions. In addition, we will discuss the diverse range of potential physiological and pathological functions of YB-1.
| Original language | English |
|---|---|
| Pages (from-to) | 691-698 |
| Number of pages | 8 |
| Journal | BioEssays |
| Volume | 25 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - Jul 1 2003 |
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All Science Journal Classification (ASJC) codes
- Biochemistry, Genetics and Molecular Biology(all)
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The pleiotropic functions of the Y-box-binding protein, YB-1. / Kohno, Kimitoshi; Izumi, Hiroto; Uchiumi, Takeshi; Ashizuka, Megumi; Kuwano, Michihiko.
In: BioEssays, Vol. 25, No. 7, 01.07.2003, p. 691-698.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - The pleiotropic functions of the Y-box-binding protein, YB-1
AU - Kohno, Kimitoshi
AU - Izumi, Hiroto
AU - Uchiumi, Takeshi
AU - Ashizuka, Megumi
AU - Kuwano, Michihiko
PY - 2003/7/1
Y1 - 2003/7/1
N2 - The Y-box-binding protein (YB-1) represents the most evolutionary conserved nucleic-acid-binding protein currently known. YB-1 is a member of the cold-shock domain (CSD) protein superfamily. It performs a wide variety of cellular functions, including transcriptional regulation, translational regulation, DNA repair, drug resistance and stress responses to extracellular signals. As a result, YB-1 expression is closely associated with cell proliferation. In this review, we will begin by briefly describing the characteristics of YB-1 and will then summarize the pleiotropic functions brought about via DNA-RNA transaction and protein-protein interactions. In addition, we will discuss the diverse range of potential physiological and pathological functions of YB-1.
AB - The Y-box-binding protein (YB-1) represents the most evolutionary conserved nucleic-acid-binding protein currently known. YB-1 is a member of the cold-shock domain (CSD) protein superfamily. It performs a wide variety of cellular functions, including transcriptional regulation, translational regulation, DNA repair, drug resistance and stress responses to extracellular signals. As a result, YB-1 expression is closely associated with cell proliferation. In this review, we will begin by briefly describing the characteristics of YB-1 and will then summarize the pleiotropic functions brought about via DNA-RNA transaction and protein-protein interactions. In addition, we will discuss the diverse range of potential physiological and pathological functions of YB-1.
UR - http://www.scopus.com/inward/record.url?scp=0037829212&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037829212&partnerID=8YFLogxK
U2 - 10.1002/bies.10300
DO - 10.1002/bies.10300
M3 - Review article
C2 - 12815724
AN - SCOPUS:0037829212
VL - 25
SP - 691
EP - 698
JO - BioEssays
JF - BioEssays
SN - 0265-9247
IS - 7
ER -