The pleiotropic functions of the Y-box-binding protein, YB-1

Kimitoshi Kohno, Hiroto Izumi, Takeshi Uchiumi, Megumi Ashizuka, Michihiko Kuwano

Research output: Contribution to journalReview article

372 Citations (Scopus)

Abstract

The Y-box-binding protein (YB-1) represents the most evolutionary conserved nucleic-acid-binding protein currently known. YB-1 is a member of the cold-shock domain (CSD) protein superfamily. It performs a wide variety of cellular functions, including transcriptional regulation, translational regulation, DNA repair, drug resistance and stress responses to extracellular signals. As a result, YB-1 expression is closely associated with cell proliferation. In this review, we will begin by briefly describing the characteristics of YB-1 and will then summarize the pleiotropic functions brought about via DNA-RNA transaction and protein-protein interactions. In addition, we will discuss the diverse range of potential physiological and pathological functions of YB-1.

Original languageEnglish
Pages (from-to)691-698
Number of pages8
JournalBioEssays
Volume25
Issue number7
DOIs
Publication statusPublished - Jul 1 2003

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Y-Box-Binding Protein 1
Cold Shock Proteins and Peptides
Drug Resistance
DNA Repair
Nucleic Acids
Carrier Proteins
Proteins
DNA
Cell Proliferation
Cell proliferation
RNA
Repair
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

The pleiotropic functions of the Y-box-binding protein, YB-1. / Kohno, Kimitoshi; Izumi, Hiroto; Uchiumi, Takeshi; Ashizuka, Megumi; Kuwano, Michihiko.

In: BioEssays, Vol. 25, No. 7, 01.07.2003, p. 691-698.

Research output: Contribution to journalReview article

Kohno, K, Izumi, H, Uchiumi, T, Ashizuka, M & Kuwano, M 2003, 'The pleiotropic functions of the Y-box-binding protein, YB-1', BioEssays, vol. 25, no. 7, pp. 691-698. https://doi.org/10.1002/bies.10300
Kohno, Kimitoshi ; Izumi, Hiroto ; Uchiumi, Takeshi ; Ashizuka, Megumi ; Kuwano, Michihiko. / The pleiotropic functions of the Y-box-binding protein, YB-1. In: BioEssays. 2003 ; Vol. 25, No. 7. pp. 691-698.
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