TY - JOUR
T1 - The pleiotropic role of non-coding genes in development and cancer
AU - Pasut, Alessandra
AU - Matsumoto, Akinobu
AU - Clohessy, John G.
AU - Pandolfi, Pier Paolo
N1 - Funding Information:
We would like to thank current members of the Pandolfi laboratory for critical discussion, and Lauren Southwood for insightful editing. This work is funded by grants from HFSP [ GP000912014 ] and from NIH/NCI [ R35CA197529-01 ].
Publisher Copyright:
© 2016 Elsevier Ltd
PY - 2016/12/1
Y1 - 2016/12/1
N2 - The expansive dimension of non-coding genes is by now a well-recognized feature of eukaryotes genomes. Over the past decades, in vitro functional studies and in vivo manipulation of non-coding genes through Genetically Engineered Mouse Models (GEMMs) have provided compelling evidence that almost every biological phenomenon is regulated, at some level, by non-coding RNA transcripts or by coding RNAs with non-coding functions. In this opinion article, we will discuss how recent discoveries in the field of non-coding RNAs are contributing to advance our understanding of evolution and organismal complexity and its relevance to human diseases.
AB - The expansive dimension of non-coding genes is by now a well-recognized feature of eukaryotes genomes. Over the past decades, in vitro functional studies and in vivo manipulation of non-coding genes through Genetically Engineered Mouse Models (GEMMs) have provided compelling evidence that almost every biological phenomenon is regulated, at some level, by non-coding RNA transcripts or by coding RNAs with non-coding functions. In this opinion article, we will discuss how recent discoveries in the field of non-coding RNAs are contributing to advance our understanding of evolution and organismal complexity and its relevance to human diseases.
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U2 - 10.1016/j.ceb.2016.10.005
DO - 10.1016/j.ceb.2016.10.005
M3 - Review article
C2 - 27865128
AN - SCOPUS:84995678231
SN - 0955-0674
VL - 43
SP - 104
EP - 113
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
ER -
