The pleiotropic role of non-coding genes in development and cancer

Alessandra Pasut, Akinobu Matsumoto, John G. Clohessy, Pier Paolo Pandolfi

Research output: Contribution to journalReview article

13 Citations (Scopus)

Abstract

The expansive dimension of non-coding genes is by now a well-recognized feature of eukaryotes genomes. Over the past decades, in vitro functional studies and in vivo manipulation of non-coding genes through Genetically Engineered Mouse Models (GEMMs) have provided compelling evidence that almost every biological phenomenon is regulated, at some level, by non-coding RNA transcripts or by coding RNAs with non-coding functions. In this opinion article, we will discuss how recent discoveries in the field of non-coding RNAs are contributing to advance our understanding of evolution and organismal complexity and its relevance to human diseases.

Original languageEnglish
Pages (from-to)104-113
Number of pages10
JournalCurrent Opinion in Cell Biology
Volume43
DOIs
Publication statusPublished - Dec 1 2016
Externally publishedYes

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Untranslated RNA
Genes
Neoplasms
Biological Phenomena
Eukaryota
Genome

All Science Journal Classification (ASJC) codes

  • Cell Biology

Cite this

The pleiotropic role of non-coding genes in development and cancer. / Pasut, Alessandra; Matsumoto, Akinobu; Clohessy, John G.; Pandolfi, Pier Paolo.

In: Current Opinion in Cell Biology, Vol. 43, 01.12.2016, p. 104-113.

Research output: Contribution to journalReview article

Pasut, Alessandra ; Matsumoto, Akinobu ; Clohessy, John G. ; Pandolfi, Pier Paolo. / The pleiotropic role of non-coding genes in development and cancer. In: Current Opinion in Cell Biology. 2016 ; Vol. 43. pp. 104-113.
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