TY - JOUR
T1 - The Plot Thickens
T2 - The Emerging Role of Matrix Viscosity in Cell Mechanotransduction
AU - Cantini, Marco
AU - Donnelly, Hannah
AU - Dalby, Matthew J.
AU - Salmeron-Sanchez, Manuel
N1 - Funding Information:
M.C. and H.D. contributed equally to this work. The support from the UK Engineering and Physical Sciences Research Council (EP/P001114/1) and from the MRC (MR/S005412/1) is acknowledged. This work was also funded by a grant from the UK Regenerative Medicine Platform (MR/R015651/1).
Publisher Copyright:
© 2019 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
PY - 2020/4/1
Y1 - 2020/4/1
N2 - Cell mechanotransduction is an area of intense research focus. Until now, very limited tools have existed to study how cells respond to changes in the extracellular matrix beyond, for example, mechanical deformation studies and twisting cytometry. However, emerging are a range of elastic, viscoelastic and even purely viscous materials that deform and dissipate on cellular length and timescales. This article reviews developments in these materials, typically translating from 2D model surfaces to 3D microenvironments and explores how cells interact with them. Specifically, it focuses on emerging concepts such as the molecular clutch model, how different extracellular matrix proteins engage the clutch under viscoelastic-stress relaxation conditions, and how mechanotransduction can drive transcriptional control through regulators such as YAP/TAZ.
AB - Cell mechanotransduction is an area of intense research focus. Until now, very limited tools have existed to study how cells respond to changes in the extracellular matrix beyond, for example, mechanical deformation studies and twisting cytometry. However, emerging are a range of elastic, viscoelastic and even purely viscous materials that deform and dissipate on cellular length and timescales. This article reviews developments in these materials, typically translating from 2D model surfaces to 3D microenvironments and explores how cells interact with them. Specifically, it focuses on emerging concepts such as the molecular clutch model, how different extracellular matrix proteins engage the clutch under viscoelastic-stress relaxation conditions, and how mechanotransduction can drive transcriptional control through regulators such as YAP/TAZ.
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U2 - 10.1002/adhm.201901259
DO - 10.1002/adhm.201901259
M3 - Review article
C2 - 31815372
AN - SCOPUS:85076337312
SN - 2192-2640
VL - 9
JO - Advanced healthcare materials
JF - Advanced healthcare materials
IS - 8
M1 - 1901259
ER -