The preoperative controlling nutritional status score predicts survival after curative surgery in patients with pathological stage i non-small cell lung cancer

Fumihiro Shoji, Naoki Haratake, Takaki Akamine, Shinkichi Takamori, Masakazu Katsura, Kazuki Takada, Gouji Toyokawa, Tatsuro Okamoto, Yoshihiko Maehara

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background: The prognostic Controlling Nutritional Status (CONUT) score is used to evaluate immuno-nutritional conditions and is a predictive factor of postoperative survival in patients with digestive tract cancer. We retrospectively analyzed clinicopathological features of patients with pathological stage I non-small cell lung cancer (NSCLC) to identify predictors or prognostic factors of postoperative survival and to investigate the role of preoperative CONUT score in predicting survival. Patients and Methods: We selected 138 consecutive patients with pathological stage I NSCLC treated from August 2005 to August 2010. We measured their preoperative CONUT score in uni-and multivariate Cox regression analyses of postoperative survival. Results: A high CONUT score was positively associated with preoperative serum carcinoembryonic antigen level (p=0.0100) and postoperative recurrence (p=0.0767). In multivariate analysis, the preoperative CONUT score [relative risk (RR)=6.058; 95% confidence interval (CI)=1.068-113.941; p=0.0407), increasing age (RR=7.858; 95% CI=2.034-36.185; p=0.0029), and pleural invasion (RR=36.615; 95% CI=5.900-362.620; p<0.0001) were independent prognostic factors. In Kaplan-Meier analysis of recurrence-free survival (RFS), cancer-specific survival (CS), and overall survival (OS), the group with high CONUT score had a significantly shorter RFS, CS, and OS than did the low-CONUT score group by log-rank test (p=0.0458, p=0.0104 and p=0.0096, respectively). Conclusion: The preoperative CONUT score is both a predictive and prognostic factor in patients with pathological stage I NSCLC. This immuno-nutritional score can indicate patients at high risk of postoperative recurrence and death.

Original languageEnglish
Pages (from-to)741-748
Number of pages8
JournalAnticancer research
Volume37
Issue number2
DOIs
Publication statusPublished - Jan 1 2017

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Nutritional Status
Non-Small Cell Lung Carcinoma
Survival
Recurrence
Confidence Intervals
Neoplasms
Carcinoembryonic Antigen
Kaplan-Meier Estimate
Gastrointestinal Tract
Multivariate Analysis
Regression Analysis

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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The preoperative controlling nutritional status score predicts survival after curative surgery in patients with pathological stage i non-small cell lung cancer. / Shoji, Fumihiro; Haratake, Naoki; Akamine, Takaki; Takamori, Shinkichi; Katsura, Masakazu; Takada, Kazuki; Toyokawa, Gouji; Okamoto, Tatsuro; Maehara, Yoshihiko.

In: Anticancer research, Vol. 37, No. 2, 01.01.2017, p. 741-748.

Research output: Contribution to journalArticle

Shoji, F, Haratake, N, Akamine, T, Takamori, S, Katsura, M, Takada, K, Toyokawa, G, Okamoto, T & Maehara, Y 2017, 'The preoperative controlling nutritional status score predicts survival after curative surgery in patients with pathological stage i non-small cell lung cancer', Anticancer research, vol. 37, no. 2, pp. 741-748. https://doi.org/10.21873/anticanres.11372
Shoji, Fumihiro ; Haratake, Naoki ; Akamine, Takaki ; Takamori, Shinkichi ; Katsura, Masakazu ; Takada, Kazuki ; Toyokawa, Gouji ; Okamoto, Tatsuro ; Maehara, Yoshihiko. / The preoperative controlling nutritional status score predicts survival after curative surgery in patients with pathological stage i non-small cell lung cancer. In: Anticancer research. 2017 ; Vol. 37, No. 2. pp. 741-748.
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abstract = "Background: The prognostic Controlling Nutritional Status (CONUT) score is used to evaluate immuno-nutritional conditions and is a predictive factor of postoperative survival in patients with digestive tract cancer. We retrospectively analyzed clinicopathological features of patients with pathological stage I non-small cell lung cancer (NSCLC) to identify predictors or prognostic factors of postoperative survival and to investigate the role of preoperative CONUT score in predicting survival. Patients and Methods: We selected 138 consecutive patients with pathological stage I NSCLC treated from August 2005 to August 2010. We measured their preoperative CONUT score in uni-and multivariate Cox regression analyses of postoperative survival. Results: A high CONUT score was positively associated with preoperative serum carcinoembryonic antigen level (p=0.0100) and postoperative recurrence (p=0.0767). In multivariate analysis, the preoperative CONUT score [relative risk (RR)=6.058; 95{\%} confidence interval (CI)=1.068-113.941; p=0.0407), increasing age (RR=7.858; 95{\%} CI=2.034-36.185; p=0.0029), and pleural invasion (RR=36.615; 95{\%} CI=5.900-362.620; p<0.0001) were independent prognostic factors. In Kaplan-Meier analysis of recurrence-free survival (RFS), cancer-specific survival (CS), and overall survival (OS), the group with high CONUT score had a significantly shorter RFS, CS, and OS than did the low-CONUT score group by log-rank test (p=0.0458, p=0.0104 and p=0.0096, respectively). Conclusion: The preoperative CONUT score is both a predictive and prognostic factor in patients with pathological stage I NSCLC. This immuno-nutritional score can indicate patients at high risk of postoperative recurrence and death.",
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T1 - The preoperative controlling nutritional status score predicts survival after curative surgery in patients with pathological stage i non-small cell lung cancer

AU - Shoji, Fumihiro

AU - Haratake, Naoki

AU - Akamine, Takaki

AU - Takamori, Shinkichi

AU - Katsura, Masakazu

AU - Takada, Kazuki

AU - Toyokawa, Gouji

AU - Okamoto, Tatsuro

AU - Maehara, Yoshihiko

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Y1 - 2017/1/1

N2 - Background: The prognostic Controlling Nutritional Status (CONUT) score is used to evaluate immuno-nutritional conditions and is a predictive factor of postoperative survival in patients with digestive tract cancer. We retrospectively analyzed clinicopathological features of patients with pathological stage I non-small cell lung cancer (NSCLC) to identify predictors or prognostic factors of postoperative survival and to investigate the role of preoperative CONUT score in predicting survival. Patients and Methods: We selected 138 consecutive patients with pathological stage I NSCLC treated from August 2005 to August 2010. We measured their preoperative CONUT score in uni-and multivariate Cox regression analyses of postoperative survival. Results: A high CONUT score was positively associated with preoperative serum carcinoembryonic antigen level (p=0.0100) and postoperative recurrence (p=0.0767). In multivariate analysis, the preoperative CONUT score [relative risk (RR)=6.058; 95% confidence interval (CI)=1.068-113.941; p=0.0407), increasing age (RR=7.858; 95% CI=2.034-36.185; p=0.0029), and pleural invasion (RR=36.615; 95% CI=5.900-362.620; p<0.0001) were independent prognostic factors. In Kaplan-Meier analysis of recurrence-free survival (RFS), cancer-specific survival (CS), and overall survival (OS), the group with high CONUT score had a significantly shorter RFS, CS, and OS than did the low-CONUT score group by log-rank test (p=0.0458, p=0.0104 and p=0.0096, respectively). Conclusion: The preoperative CONUT score is both a predictive and prognostic factor in patients with pathological stage I NSCLC. This immuno-nutritional score can indicate patients at high risk of postoperative recurrence and death.

AB - Background: The prognostic Controlling Nutritional Status (CONUT) score is used to evaluate immuno-nutritional conditions and is a predictive factor of postoperative survival in patients with digestive tract cancer. We retrospectively analyzed clinicopathological features of patients with pathological stage I non-small cell lung cancer (NSCLC) to identify predictors or prognostic factors of postoperative survival and to investigate the role of preoperative CONUT score in predicting survival. Patients and Methods: We selected 138 consecutive patients with pathological stage I NSCLC treated from August 2005 to August 2010. We measured their preoperative CONUT score in uni-and multivariate Cox regression analyses of postoperative survival. Results: A high CONUT score was positively associated with preoperative serum carcinoembryonic antigen level (p=0.0100) and postoperative recurrence (p=0.0767). In multivariate analysis, the preoperative CONUT score [relative risk (RR)=6.058; 95% confidence interval (CI)=1.068-113.941; p=0.0407), increasing age (RR=7.858; 95% CI=2.034-36.185; p=0.0029), and pleural invasion (RR=36.615; 95% CI=5.900-362.620; p<0.0001) were independent prognostic factors. In Kaplan-Meier analysis of recurrence-free survival (RFS), cancer-specific survival (CS), and overall survival (OS), the group with high CONUT score had a significantly shorter RFS, CS, and OS than did the low-CONUT score group by log-rank test (p=0.0458, p=0.0104 and p=0.0096, respectively). Conclusion: The preoperative CONUT score is both a predictive and prognostic factor in patients with pathological stage I NSCLC. This immuno-nutritional score can indicate patients at high risk of postoperative recurrence and death.

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