Abstract
The infiltration of leukocytes into inflammation sites such as observed in human periapical granulomas is considered to be mediated by chemotactic factors. In this study, we examined the presence of chemokine- and chemokine receptor-positive cells in samples obtained from human subjects by means of immunohistochemical methods. Macrophage chemotactic protein-1 (MCP-1), macrophage inflammatory protein (MIP)-1α, MIP-1β and IFN-inducible protein 10 (IP-10)-producing cells were present in periapical granulomas. In addition, chemokine receptor CCR3-, CCR5-, and CXCR3-positive cells were also present. In contrast, no factor expression was observed in clinically healthy periodontal ligament, serving as a negative control. Our findings suggest that these chemokines are responsible for modulating the process of disease, such as human apical periodontitis.
| Original language | English |
|---|---|
| Pages (from-to) | 62-66 |
| Number of pages | 5 |
| Journal | Cytokine |
| Volume | 16 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Jan 1 2001 |
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All Science Journal Classification (ASJC) codes
- Immunology and Allergy
- Immunology
- Biochemistry
- Hematology
- Molecular Biology
Cite this
The presence of chemokine receptor (CCR5, CXCR3, CCR3)-positive cells and chemokine (MCP-1, MIP-1α, MIP-1β, IP-10)-positive cells in human periapical granulomas. / Kabashima, Hiroaki; Yoneda, Masahiro; Nagata, Kengo; Hirofuji, Takao; Ishihara, Yoshihisa; Yamashita, Megumi; Maeda, Katsumasa.
In: Cytokine, Vol. 16, No. 2, 01.01.2001, p. 62-66.Research output: Contribution to journal › Article
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TY - JOUR
T1 - The presence of chemokine receptor (CCR5, CXCR3, CCR3)-positive cells and chemokine (MCP-1, MIP-1α, MIP-1β, IP-10)-positive cells in human periapical granulomas
AU - Kabashima, Hiroaki
AU - Yoneda, Masahiro
AU - Nagata, Kengo
AU - Hirofuji, Takao
AU - Ishihara, Yoshihisa
AU - Yamashita, Megumi
AU - Maeda, Katsumasa
PY - 2001/1/1
Y1 - 2001/1/1
N2 - The infiltration of leukocytes into inflammation sites such as observed in human periapical granulomas is considered to be mediated by chemotactic factors. In this study, we examined the presence of chemokine- and chemokine receptor-positive cells in samples obtained from human subjects by means of immunohistochemical methods. Macrophage chemotactic protein-1 (MCP-1), macrophage inflammatory protein (MIP)-1α, MIP-1β and IFN-inducible protein 10 (IP-10)-producing cells were present in periapical granulomas. In addition, chemokine receptor CCR3-, CCR5-, and CXCR3-positive cells were also present. In contrast, no factor expression was observed in clinically healthy periodontal ligament, serving as a negative control. Our findings suggest that these chemokines are responsible for modulating the process of disease, such as human apical periodontitis.
AB - The infiltration of leukocytes into inflammation sites such as observed in human periapical granulomas is considered to be mediated by chemotactic factors. In this study, we examined the presence of chemokine- and chemokine receptor-positive cells in samples obtained from human subjects by means of immunohistochemical methods. Macrophage chemotactic protein-1 (MCP-1), macrophage inflammatory protein (MIP)-1α, MIP-1β and IFN-inducible protein 10 (IP-10)-producing cells were present in periapical granulomas. In addition, chemokine receptor CCR3-, CCR5-, and CXCR3-positive cells were also present. In contrast, no factor expression was observed in clinically healthy periodontal ligament, serving as a negative control. Our findings suggest that these chemokines are responsible for modulating the process of disease, such as human apical periodontitis.
UR - http://www.scopus.com/inward/record.url?scp=0036059248&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036059248&partnerID=8YFLogxK
U2 - 10.1006/cyto.2001.0947
DO - 10.1006/cyto.2001.0947
M3 - Article
C2 - 11683586
AN - SCOPUS:0036059248
VL - 16
SP - 62
EP - 66
JO - Cytokine
JF - Cytokine
SN - 1043-4666
IS - 2
ER -