The presence of cytokine (IL-8, IL-1α, IL-1β)-producing cells in inflamed gingival tissue from a patient manifesting papillon-lefevre syndrome (PLS)

Hiroaki Kabashima; Masahiro Yoneda; Kengo Nagata; Kazuaki Nonaka; Takao Hirofuji; Katsumasa Maeda

doi:10.1006/cyto.2002.1005

The presence of cytokine (IL-8, IL-1α, IL-1β)-producing cells in inflamed gingival tissue from a patient manifesting papillon-lefevre syndrome (PLS)

Hiroaki Kabashima, Masahiro Yoneda, Kengo Nagata, Kazuaki Nonaka, Takao Hirofuji, Katsumasa Maeda

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

The point of this study was to examine the presence or absence of cytokine-positive cells by means of immunohistochemical methods in the samples of inflamed gingival tissues obtained from an 11-year-old girl with Papillon-Lefevre syndrome (PLS). Interleukin-8 (IL-8)-positive cells were found to be present. In addition, IL-1α-and IL-1β-positive cells were detected. No dysfunction in the phagocytosis and the bacterial killing of peripheral blood polymorphonuclear neutrophils (PMNs) was observed in this patient. Our findings suggest that these cytokines may be members responsible for modulating the process of rapidly progressive periodontitis for patient with PLS.

Original language	English
Pages (from-to)	121-126
Number of pages	6
Journal	Cytokine
Volume	18
Issue number	3
DOIs	https://doi.org/10.1006/cyto.2002.1005
Publication status	Published - 2002

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Immunology
Biochemistry
Hematology
Molecular Biology

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The presence of cytokine (IL-8, IL-1α, IL-1β)-producing cells in inflamed gingival tissue from a patient manifesting papillon-lefevre syndrome (PLS). / Kabashima, Hiroaki; Yoneda, Masahiro; Nagata, Kengo; Nonaka, Kazuaki; Hirofuji, Takao; Maeda, Katsumasa.

In: Cytokine, Vol. 18, No. 3, 2002, p. 121-126.

Research output: Contribution to journal › Article › peer-review

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abstract = "The point of this study was to examine the presence or absence of cytokine-positive cells by means of immunohistochemical methods in the samples of inflamed gingival tissues obtained from an 11-year-old girl with Papillon-Lefevre syndrome (PLS). Interleukin-8 (IL-8)-positive cells were found to be present. In addition, IL-1α-and IL-1β-positive cells were detected. No dysfunction in the phagocytosis and the bacterial killing of peripheral blood polymorphonuclear neutrophils (PMNs) was observed in this patient. Our findings suggest that these cytokines may be members responsible for modulating the process of rapidly progressive periodontitis for patient with PLS.",

author = "Hiroaki Kabashima and Masahiro Yoneda and Kengo Nagata and Kazuaki Nonaka and Takao Hirofuji and Katsumasa Maeda",

note = "Funding Information: This work was supported in part by a Grants-in-Aid for Scientific Research 13672189 from the Ministry of Education, Science, Sports and Culture of Japan. We sincerely thank Sunstar Inc. for providing us with some oral rinses which helped to improve the periodontal condition of this patient.",

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AU - Nagata, Kengo

AU - Nonaka, Kazuaki

AU - Hirofuji, Takao

AU - Maeda, Katsumasa

N1 - Funding Information: This work was supported in part by a Grants-in-Aid for Scientific Research 13672189 from the Ministry of Education, Science, Sports and Culture of Japan. We sincerely thank Sunstar Inc. for providing us with some oral rinses which helped to improve the periodontal condition of this patient.

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