The presence of cytokine (IL-8, IL-1α, IL-1β)-producing cells in inflamed gingival tissue from a patient manifesting papillon-lefevre syndrome (PLS)

Hiroaki Kabashima, Masahiro Yoneda, Kengo Nagata, Kazuaki Nonaka, Takao Hirofuji, Katsumasa Maeda

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4 Citations (Scopus)

Abstract

The point of this study was to examine the presence or absence of cytokine-positive cells by means of immunohistochemical methods in the samples of inflamed gingival tissues obtained from an 11-year-old girl with Papillon-Lefevre syndrome (PLS). Interleukin-8 (IL-8)-positive cells were found to be present. In addition, IL-1α-and IL-1β-positive cells were detected. No dysfunction in the phagocytosis and the bacterial killing of peripheral blood polymorphonuclear neutrophils (PMNs) was observed in this patient. Our findings suggest that these cytokines may be members responsible for modulating the process of rapidly progressive periodontitis for patient with PLS.

Original languageEnglish
Pages (from-to)121-126
Number of pages6
JournalCytokine
Volume18
Issue number3
DOIs
Publication statusPublished - 2002

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Biochemistry
  • Hematology
  • Molecular Biology

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