The principal of dynamic contrast enhanced MRI, the method of pharmacokinetic analysis, and its application in the head and neck region

Toru Chikui, Makoto Obara, Arjan W. Simonetti, Masahiro Ohga, Shoichi Koga, Shintaro Kawano, Yoshio Matsuo, Takeshi Kamintani, Tomoko Shiraishi, Erina Kitamoto, Katsumasa Nakamura, Kazunori Yoshiura

Research output: Contribution to journalReview article

17 Citations (Scopus)

Abstract

Many researchers have established the utility of the dynamic contrast enhanced-magnetic resonance imaging (DCE-MRI) in the differential diagnosis in the head and neck region, especially in the salivary gland tumors. The subjective assessment of the pattern of the time-intensity curve (TIC) or the simple quantification of the TIC, such as the time to peak enhancement (T peak) and the wash-out ratio (WR), is commonly used. Although the semiquantitative evaluations described above have been widely applied, they do not provide information on the underlying pharmacokinetic analysis in tissue. The quantification of DCE-MRI is preferable; therefore, many compartment model analyses have been proposed. The Toft and Kermode (TK) model is one of the most popular compartment models, which provide information about the influx forward volume transfer constant from plasma into the extravascular-extracellular space (EES) and the fractional volume of EES per unit volume of tissue is used in many clinical studies. This paper will introduce the method of pharmacokinetic analysis and also describe the clinical application of this technique in the head and neck region.

Original languageEnglish
Article number480659
JournalInternational Journal of Dentistry
DOIs
Publication statusPublished - Nov 19 2012

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Neck
Pharmacokinetics
Head
Extracellular Space
Magnetic Resonance Imaging
Glandular and Epithelial Neoplasms
Differential Diagnosis
Research Personnel
Clinical Studies

All Science Journal Classification (ASJC) codes

  • Dentistry(all)

Cite this

The principal of dynamic contrast enhanced MRI, the method of pharmacokinetic analysis, and its application in the head and neck region. / Chikui, Toru; Obara, Makoto; Simonetti, Arjan W.; Ohga, Masahiro; Koga, Shoichi; Kawano, Shintaro; Matsuo, Yoshio; Kamintani, Takeshi; Shiraishi, Tomoko; Kitamoto, Erina; Nakamura, Katsumasa; Yoshiura, Kazunori.

In: International Journal of Dentistry, 19.11.2012.

Research output: Contribution to journalReview article

Chikui, Toru ; Obara, Makoto ; Simonetti, Arjan W. ; Ohga, Masahiro ; Koga, Shoichi ; Kawano, Shintaro ; Matsuo, Yoshio ; Kamintani, Takeshi ; Shiraishi, Tomoko ; Kitamoto, Erina ; Nakamura, Katsumasa ; Yoshiura, Kazunori. / The principal of dynamic contrast enhanced MRI, the method of pharmacokinetic analysis, and its application in the head and neck region. In: International Journal of Dentistry. 2012.
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