The prognostic impact of the amount of tobacco smoking in non-small cell lung cancer-Differences between adenocarcinoma and squamous cell carcinoma

Tatsuro Okamoto, Yuzo Suzuki, Takatoshi Fujishita, Hirokazu Kitahara, Shinichiro Shimamatsu, Mikihiro Kohno, Yosuke Morodomi, Daigo Kawano, Yoshihiko Maehara

Research output: Contribution to journalArticle

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Abstract

Backgrounds: The purpose of this study was to investigate the relationship between the level of tobacco smoking and the clinicopathological features of non-small cell lung cancer (NSCLC) patients, individually for adenocarcinoma (Ad) and squamous cell carcinoma (Sq). Patients and methods: We retrospectively reviewed the clinical records of 1825 consecutive lung cancer patients who underwent surgery in our department. Among these, the data sets of 750 Ad patients and 364 Sq patients who received lobectomy or more extensive resection were available. Results: In Ad patients, those who had never smoked (never-smokers) (n= 309) were more likely to be female, to have less advanced stage tumors, and to have a significantly better prognosis than those who had ever smoked (ever-smokers) (n= 441) (5-year OS: never-smokers, 67.9%; ever-smokers, 53.7%, p< 0.0001). In Sq patients, the never-smokers (n= 15) were more likely to be female than the ever-smokers (n= 349). Among ever-smokers, the light-smokers (PY ≤ 30; n= 56) were associated with more female patients, more advanced stage tumors, and significantly worse prognoses than were the heavy smokers (PY > 30; n= 292) (p= 0.0003). The multivariate survival analysis showed that light smoking was related to a worse prognosis compared with heavy smoking (HR = 2.06, 95% CI 1.43-2.98, p= 0.0001). Conclusions: The never-smokers had a significantly better prognosis than ever-smokers among Ad patients, whereas the light-smokers had a significantly worse prognosis than heavy smokers among Sq patients. There may be factors other than tobacco carcinogens that influence the development of Sq in never and/or light smokers.

Original languageEnglish
Pages (from-to)125-130
Number of pages6
JournalLung Cancer
Volume85
Issue number2
DOIs
Publication statusPublished - Aug 2014

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Non-Small Cell Lung Carcinoma
Squamous Cell Carcinoma
Adenocarcinoma
Smoking
Light
Survival Analysis
Carcinogens
Tobacco
Lung Neoplasms
Multivariate Analysis
Neoplasms

All Science Journal Classification (ASJC) codes

  • Oncology
  • Pulmonary and Respiratory Medicine
  • Cancer Research

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The prognostic impact of the amount of tobacco smoking in non-small cell lung cancer-Differences between adenocarcinoma and squamous cell carcinoma. / Okamoto, Tatsuro; Suzuki, Yuzo; Fujishita, Takatoshi; Kitahara, Hirokazu; Shimamatsu, Shinichiro; Kohno, Mikihiro; Morodomi, Yosuke; Kawano, Daigo; Maehara, Yoshihiko.

In: Lung Cancer, Vol. 85, No. 2, 08.2014, p. 125-130.

Research output: Contribution to journalArticle

Okamoto, T, Suzuki, Y, Fujishita, T, Kitahara, H, Shimamatsu, S, Kohno, M, Morodomi, Y, Kawano, D & Maehara, Y 2014, 'The prognostic impact of the amount of tobacco smoking in non-small cell lung cancer-Differences between adenocarcinoma and squamous cell carcinoma', Lung Cancer, vol. 85, no. 2, pp. 125-130. https://doi.org/10.1016/j.lungcan.2014.06.006
Okamoto, Tatsuro ; Suzuki, Yuzo ; Fujishita, Takatoshi ; Kitahara, Hirokazu ; Shimamatsu, Shinichiro ; Kohno, Mikihiro ; Morodomi, Yosuke ; Kawano, Daigo ; Maehara, Yoshihiko. / The prognostic impact of the amount of tobacco smoking in non-small cell lung cancer-Differences between adenocarcinoma and squamous cell carcinoma. In: Lung Cancer. 2014 ; Vol. 85, No. 2. pp. 125-130.
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abstract = "Backgrounds: The purpose of this study was to investigate the relationship between the level of tobacco smoking and the clinicopathological features of non-small cell lung cancer (NSCLC) patients, individually for adenocarcinoma (Ad) and squamous cell carcinoma (Sq). Patients and methods: We retrospectively reviewed the clinical records of 1825 consecutive lung cancer patients who underwent surgery in our department. Among these, the data sets of 750 Ad patients and 364 Sq patients who received lobectomy or more extensive resection were available. Results: In Ad patients, those who had never smoked (never-smokers) (n= 309) were more likely to be female, to have less advanced stage tumors, and to have a significantly better prognosis than those who had ever smoked (ever-smokers) (n= 441) (5-year OS: never-smokers, 67.9{\%}; ever-smokers, 53.7{\%}, p< 0.0001). In Sq patients, the never-smokers (n= 15) were more likely to be female than the ever-smokers (n= 349). Among ever-smokers, the light-smokers (PY ≤ 30; n= 56) were associated with more female patients, more advanced stage tumors, and significantly worse prognoses than were the heavy smokers (PY > 30; n= 292) (p= 0.0003). The multivariate survival analysis showed that light smoking was related to a worse prognosis compared with heavy smoking (HR = 2.06, 95{\%} CI 1.43-2.98, p= 0.0001). Conclusions: The never-smokers had a significantly better prognosis than ever-smokers among Ad patients, whereas the light-smokers had a significantly worse prognosis than heavy smokers among Sq patients. There may be factors other than tobacco carcinogens that influence the development of Sq in never and/or light smokers.",
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AU - Okamoto, Tatsuro

AU - Suzuki, Yuzo

AU - Fujishita, Takatoshi

AU - Kitahara, Hirokazu

AU - Shimamatsu, Shinichiro

AU - Kohno, Mikihiro

AU - Morodomi, Yosuke

AU - Kawano, Daigo

AU - Maehara, Yoshihiko

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N2 - Backgrounds: The purpose of this study was to investigate the relationship between the level of tobacco smoking and the clinicopathological features of non-small cell lung cancer (NSCLC) patients, individually for adenocarcinoma (Ad) and squamous cell carcinoma (Sq). Patients and methods: We retrospectively reviewed the clinical records of 1825 consecutive lung cancer patients who underwent surgery in our department. Among these, the data sets of 750 Ad patients and 364 Sq patients who received lobectomy or more extensive resection were available. Results: In Ad patients, those who had never smoked (never-smokers) (n= 309) were more likely to be female, to have less advanced stage tumors, and to have a significantly better prognosis than those who had ever smoked (ever-smokers) (n= 441) (5-year OS: never-smokers, 67.9%; ever-smokers, 53.7%, p< 0.0001). In Sq patients, the never-smokers (n= 15) were more likely to be female than the ever-smokers (n= 349). Among ever-smokers, the light-smokers (PY ≤ 30; n= 56) were associated with more female patients, more advanced stage tumors, and significantly worse prognoses than were the heavy smokers (PY > 30; n= 292) (p= 0.0003). The multivariate survival analysis showed that light smoking was related to a worse prognosis compared with heavy smoking (HR = 2.06, 95% CI 1.43-2.98, p= 0.0001). Conclusions: The never-smokers had a significantly better prognosis than ever-smokers among Ad patients, whereas the light-smokers had a significantly worse prognosis than heavy smokers among Sq patients. There may be factors other than tobacco carcinogens that influence the development of Sq in never and/or light smokers.

AB - Backgrounds: The purpose of this study was to investigate the relationship between the level of tobacco smoking and the clinicopathological features of non-small cell lung cancer (NSCLC) patients, individually for adenocarcinoma (Ad) and squamous cell carcinoma (Sq). Patients and methods: We retrospectively reviewed the clinical records of 1825 consecutive lung cancer patients who underwent surgery in our department. Among these, the data sets of 750 Ad patients and 364 Sq patients who received lobectomy or more extensive resection were available. Results: In Ad patients, those who had never smoked (never-smokers) (n= 309) were more likely to be female, to have less advanced stage tumors, and to have a significantly better prognosis than those who had ever smoked (ever-smokers) (n= 441) (5-year OS: never-smokers, 67.9%; ever-smokers, 53.7%, p< 0.0001). In Sq patients, the never-smokers (n= 15) were more likely to be female than the ever-smokers (n= 349). Among ever-smokers, the light-smokers (PY ≤ 30; n= 56) were associated with more female patients, more advanced stage tumors, and significantly worse prognoses than were the heavy smokers (PY > 30; n= 292) (p= 0.0003). The multivariate survival analysis showed that light smoking was related to a worse prognosis compared with heavy smoking (HR = 2.06, 95% CI 1.43-2.98, p= 0.0001). Conclusions: The never-smokers had a significantly better prognosis than ever-smokers among Ad patients, whereas the light-smokers had a significantly worse prognosis than heavy smokers among Sq patients. There may be factors other than tobacco carcinogens that influence the development of Sq in never and/or light smokers.

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