TY - JOUR
T1 - The prognostic significance of the cytophotometric DNA content and its relationship with the argyrophilic nucleolar organizer regions (AgNOR) and proliferating cell nuclear antigen (PCNA) in oesophageal cancer
AU - Kuwano, Hiroyuki
AU - Sumiyoshi, Kohei
AU - Nozoe, Tadahiro
AU - Yasuda, Mitsuhiro
AU - Watanabe, Masayuki
AU - Sugimachi, Keizo
N1 - Funding Information:
The authors thank Brian T. Quinn for critical comments. This work was supported, in part, by Grant no. 3986 from the Japanese Minstry of Education and by the Fukuoka Cancer Society.
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1995/8
Y1 - 1995/8
N2 - We examined the DNA pattern, AgNOR number and PCNA-positive ratio (PCNA ratio) from biopsy specimens of oesophageal carcinoma, and attempted to indentify any prognostic factors for oesophageal carcinoma. DNA analysis: the cell nuclear DNA content was measured and the distribution pattern of the DNA content was grouped into four types according to the ploidy pattern (n = 182). The survival rate of patients with high-ploidy tumours (type III and IV) was shorter than that for low-ploidy tumours (type II), (P < 0.05). AgNOR number (n = 99) and PCNA ratio (n = 41): the AgNOR number and PCNA ratio were measured from 100 cancer cells in each specimen. Both the high-AgNOR-number patients (≥ 5) and the high-PCNA-ratio patients (≥ 35) demonstrated poorer prognoses than the low-rate patients (P < 0.05). These results suggest that the DNA pattern, AgNOR number and PCNA ratio may thus reflect the proliferative activity of tumours and therefore also offer the possibility of interdependence among these three factors.
AB - We examined the DNA pattern, AgNOR number and PCNA-positive ratio (PCNA ratio) from biopsy specimens of oesophageal carcinoma, and attempted to indentify any prognostic factors for oesophageal carcinoma. DNA analysis: the cell nuclear DNA content was measured and the distribution pattern of the DNA content was grouped into four types according to the ploidy pattern (n = 182). The survival rate of patients with high-ploidy tumours (type III and IV) was shorter than that for low-ploidy tumours (type II), (P < 0.05). AgNOR number (n = 99) and PCNA ratio (n = 41): the AgNOR number and PCNA ratio were measured from 100 cancer cells in each specimen. Both the high-AgNOR-number patients (≥ 5) and the high-PCNA-ratio patients (≥ 35) demonstrated poorer prognoses than the low-rate patients (P < 0.05). These results suggest that the DNA pattern, AgNOR number and PCNA ratio may thus reflect the proliferative activity of tumours and therefore also offer the possibility of interdependence among these three factors.
UR - http://www.scopus.com/inward/record.url?scp=0029117430&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029117430&partnerID=8YFLogxK
U2 - 10.1016/S0748-7983(95)92384-5
DO - 10.1016/S0748-7983(95)92384-5
M3 - Article
C2 - 7664900
AN - SCOPUS:0029117430
SN - 0748-7983
VL - 21
SP - 368
EP - 373
JO - European Journal of Surgical Oncology
JF - European Journal of Surgical Oncology
IS - 4
ER -
