The prognostic significance of tumor-associated antigen 22-1-1 expression in adenocarcinoma of the uterine cervix

Tsunehisa Kaku, Kenzo Sonoda, Toshiharu Kamura, Toshio Hirakawa, Kunihiro Sakai, Satoshi Amada, Shinji Ogawa, Hiroaki Kobayashi, Manabu Nakashima, Takeshi Watanabe, Hitoo Nakano

Research output: Contribution to journalArticlepeer-review

56 Citations (Scopus)

Abstract

We previously established (K. Sonoda et al., Int. J. Oncol., 6: 1099- 1104, 1995) a novel monoclonal antibody, 22-1-1, generated from adenocarcinoma of the uterine cervix, and 22-1-1 antigen (Ag) was expressed in cancer cells derived mainly from the uterus and ovary. In this report, a relationship between 22-1-1 Ag expression and clinicopathological variables and the prognostic significance of 22-1-1 Ag were immunohistochemically investigated in adenocarcinoma of the cervix. Of 56 cases, the 22-1-1 Ag was negative in 7, 1+ in 14, 2+ in 26 and 3+ in 9 instances. The 22-1-1 Ag existed both in the cytoplasm and on the membrane of cancer cells. There was no correlation between 22-1-1 Ag expression and age, stage, grade, myometrial invasion, lymph-vascular space invasion, lymph node metastasis, and parametrial invasion. The estimated 5-year overall survival (OS) of patients with low 22-1-1 Ag expression (-/+) and high 22-1-1 Ag expression (++/+++) were 90.5 and 71.4%, respectively. Patients with high 22-1-1 Ag expression had significantly worse OS than those with low 22-1-1 Ag expression (log- rank test, P = 0.0193). In addition, lymph-node metastasis, age, and clinical stage were significantly related to OS in univariate analysis. Multivariate analysis for OS revealed a prognostic significance in 22-1-1 Ag expression, stage, age, and grade. These data suggest that 22-1-1 Ag expression may be related to prognosis in adenocarcinoma of the cervix.

Original languageEnglish
Pages (from-to)1449-1453
Number of pages5
JournalClinical Cancer Research
Volume5
Issue number6
Publication statusPublished - Jun 1 1999

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'The prognostic significance of tumor-associated antigen 22-1-1 expression in adenocarcinoma of the uterine cervix'. Together they form a unique fingerprint.

Cite this