The progress of autologous peripheral blood stem cell transplantation

S. Inaba, Y. Ohno, Shinichi Mizuno

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

It has recently become known that sufficient numbers of multi-potent stem cells transiently appear in the peripheral blood at the time of recovery from myelosuppression after chemotherapy for collection for later transfusion (autologous peripheral blood stem cell transplantation; ABSCT). It is also known that cytokines such as G-CSF or GM-CSF enhance the mobilization of stem cells in peripheral blood. It is, therefore, easy to collect a large number of progenitor cells using the apheresis technique. We have also succeeded in developing an easy preservation method using DMSO-HES-ALBUMIN as a cryoprotective agent for simple storage in a -80 degrees C refrigerator. Furthermore, the development of measurement of CD34 positive cells become easy to estimate the contents of progenitor cells in harvested peripheral mononuclear cells. These techniques contribute to the safe and reliable practice of ABSCT. There are high expectations for ABSCT as a new technique in the cure of patients with such diseases as hematological malignancy and chemotherapy sensitive solid tumor, as it makes possible the administration of super-high dose anti-cancer drugs which cause marrow ablation.

Original languageEnglish
Pages (from-to)779-789
Number of pages11
JournalNippon rinsho. Japanese journal of clinical medicine
Volume53
Issue number3
Publication statusPublished - Jan 1 1995

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Peripheral Blood Stem Cell Transplantation
Stem Cells
Granulocyte-Macrophage Colony-Stimulating Factor
Cryoprotective Agents
Hematopoietic Stem Cell Mobilization
Drug Therapy
Blood Component Removal
Granulocyte Colony-Stimulating Factor
Hematologic Neoplasms
Dimethyl Sulfoxide
Neoplasms
Bone Marrow
Cytokines
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

The progress of autologous peripheral blood stem cell transplantation. / Inaba, S.; Ohno, Y.; Mizuno, Shinichi.

In: Nippon rinsho. Japanese journal of clinical medicine, Vol. 53, No. 3, 01.01.1995, p. 779-789.

Research output: Contribution to journalReview article

Inaba, S. ; Ohno, Y. ; Mizuno, Shinichi. / The progress of autologous peripheral blood stem cell transplantation. In: Nippon rinsho. Japanese journal of clinical medicine. 1995 ; Vol. 53, No. 3. pp. 779-789.
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