TY - JOUR
T1 - The properties of chitosan nanoemulsion/ poly (VINYL ALCOHOL) Nanocomposite membranes for wound care treatment
AU - Sosiati, H.
AU - Firmansyah, W.
AU - Nugroho, Aris W.
AU - Sudarisman,
AU - Ranti, I.
AU - Hata, S.
N1 - Funding Information:
This study was supported by a research grant of ?Penelitian Dasar Unggulan Perguruan Tinggi? 2018, contract no: 227/SP2H/LT/DRPM/2019 by the Directorate General of Higher Education (DIKTI), Ministry of Research, Technology and Higher Education, the Republic of Indonesia. The authors would like to great appreciate Mr Kunto Wandono for his assistance related to the modification of the electrospinning machine. Deep sincere appreciation also goes to Dr. Sinin bin Hamdan of Universiti Malaysia Sarawak for his comments on the manuscript.
Publisher Copyright:
© School of Engineering, Taylor’s University
PY - 2020/12
Y1 - 2020/12
N2 - The influence of chitosan nano-emulsion (CSNe) concentrations on the properties of CSNe reinforced poly (vinyl alcohol) (PVA) nanocomposites is the aim of this study. Polymer solution of CSNe with different concentrations combined with PVA having a low (PVAL) and high (PVAH) molecular weight (Mw), respectively, was fabricated to be the nanocomposite membranes by an electrospinning technique. The morphological characterization of the nanofiber formed in the membranes and the chemical group of PVA and chitosan analysis was performed by scanning electron microscopy (SEM) and Fourier- transform infrared spectroscopy (FTIR), respectively. The tensile properties of all the membrane specimens were tested according to the ASTM D-882. The neat-PVAL and CSNe/PVAL nanocomposite membranes were subjected to the in Vivo test of the open incision on mice. The results showed that an increase of CSNe concentration decreased the viscosity of CSNe-PVA polymer solution but increased the electrical conductivity. Those conditions reduced the nanofiber diameter with various fiber structures. Membranes used PVAL yielded in higher tensile strength and lower tensile modulus than those used PVAH. In Vivo test results of the CSNe/PVAL membrane showed acceptable effectiveness in the wound care treatment to the Sofra-tulle commercial membrane containing antibiotics, and both were better than the neat-PVA membrane. Thus, the CSNe/PVAL provides a promising chance for an alternative wound cover membrane.
AB - The influence of chitosan nano-emulsion (CSNe) concentrations on the properties of CSNe reinforced poly (vinyl alcohol) (PVA) nanocomposites is the aim of this study. Polymer solution of CSNe with different concentrations combined with PVA having a low (PVAL) and high (PVAH) molecular weight (Mw), respectively, was fabricated to be the nanocomposite membranes by an electrospinning technique. The morphological characterization of the nanofiber formed in the membranes and the chemical group of PVA and chitosan analysis was performed by scanning electron microscopy (SEM) and Fourier- transform infrared spectroscopy (FTIR), respectively. The tensile properties of all the membrane specimens were tested according to the ASTM D-882. The neat-PVAL and CSNe/PVAL nanocomposite membranes were subjected to the in Vivo test of the open incision on mice. The results showed that an increase of CSNe concentration decreased the viscosity of CSNe-PVA polymer solution but increased the electrical conductivity. Those conditions reduced the nanofiber diameter with various fiber structures. Membranes used PVAL yielded in higher tensile strength and lower tensile modulus than those used PVAH. In Vivo test results of the CSNe/PVAL membrane showed acceptable effectiveness in the wound care treatment to the Sofra-tulle commercial membrane containing antibiotics, and both were better than the neat-PVA membrane. Thus, the CSNe/PVAL provides a promising chance for an alternative wound cover membrane.
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M3 - Article
AN - SCOPUS:85099519914
VL - 15
SP - 4091
EP - 4106
JO - Journal of Engineering Science and Technology
JF - Journal of Engineering Science and Technology
SN - 1823-4690
IS - 6
ER -