Abstract
Background: Whether the intake of eicosapentaenoic acid (EPA) or arachidonic acid (AA) affects the risk of cancer remains unclear, and the association between the serum EPA:AA ratio and cancer risk has not been fully evaluated in general populations. Methods: A total of 3098 community-dwelling subjects aged ≥40 years were followed up for 9.6 years (2002-2012). The levels of the serum EPA:AA ratio were categorized into quartiles (< 0.29, 0.29-0.41, 0.42-0.60, and > 0.60). The risk estimates were computed using a Cox proportional hazards model. The same analyses were conducted for the serum docosahexaenoic acid to arachidonic acid (DHA:AA) ratio and individual fatty acid concentrations. Results: During the follow-up period, 121 subjects died of cancer. Age- and sex-adjusted cancer mortality increased with lower serum EPA:AA ratio levels (P trend < 0.05). In the multivariable-adjusted analysis, the subjects in the first quartile of the serum EPA:AA ratio had a 1.93-fold (95% confidence interval, 1.15-3.22) greater risk of cancer death than those in the fourth quartile. Lower serum EPA concentrations were marginally associated with higher cancer mortality (P trend < 0.11), but the serum DHA or AA concentrations and the serum DHA:AA ratio were not (all P trend > 0.37). With regard to site-specific cancers, lower serum EPA:AA ratio was associated with a higher risk of death from liver cancer. However, no such associations were detected for deaths from other cancers. Conclusions: These findings suggest that decreased level of the serum EPA:AA ratio is a significant risk factor for cancer death in the general Japanese population.
| Original language | English |
|---|---|
| Pages (from-to) | 578-583 |
| Number of pages | 6 |
| Journal | Journal of epidemiology |
| Volume | 27 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - Jan 1 2017 |
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All Science Journal Classification (ASJC) codes
- Epidemiology
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The ratio of serum eicosapentaenoic acid to arachidonic acid and risk of cancer death in a Japanese community : The Hisayama Study. / Nagata, Masaharu; Hata, Jun; Hirakawa, Yoichiro; Mukai, Naoko; Yoshida, Daigo; Ohara, Tomoyuki; Kishimoto, Hiro; Kawano, Hiroyuki; Kitazono, Takanari; Kiyohara, Yutaka; Ninomiya, Toshiharu.
In: Journal of epidemiology, Vol. 27, No. 12, 01.01.2017, p. 578-583.Research output: Contribution to journal › Article
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TY - JOUR
T1 - The ratio of serum eicosapentaenoic acid to arachidonic acid and risk of cancer death in a Japanese community
T2 - The Hisayama Study
AU - Nagata, Masaharu
AU - Hata, Jun
AU - Hirakawa, Yoichiro
AU - Mukai, Naoko
AU - Yoshida, Daigo
AU - Ohara, Tomoyuki
AU - Kishimoto, Hiro
AU - Kawano, Hiroyuki
AU - Kitazono, Takanari
AU - Kiyohara, Yutaka
AU - Ninomiya, Toshiharu
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Background: Whether the intake of eicosapentaenoic acid (EPA) or arachidonic acid (AA) affects the risk of cancer remains unclear, and the association between the serum EPA:AA ratio and cancer risk has not been fully evaluated in general populations. Methods: A total of 3098 community-dwelling subjects aged ≥40 years were followed up for 9.6 years (2002-2012). The levels of the serum EPA:AA ratio were categorized into quartiles (< 0.29, 0.29-0.41, 0.42-0.60, and > 0.60). The risk estimates were computed using a Cox proportional hazards model. The same analyses were conducted for the serum docosahexaenoic acid to arachidonic acid (DHA:AA) ratio and individual fatty acid concentrations. Results: During the follow-up period, 121 subjects died of cancer. Age- and sex-adjusted cancer mortality increased with lower serum EPA:AA ratio levels (P trend < 0.05). In the multivariable-adjusted analysis, the subjects in the first quartile of the serum EPA:AA ratio had a 1.93-fold (95% confidence interval, 1.15-3.22) greater risk of cancer death than those in the fourth quartile. Lower serum EPA concentrations were marginally associated with higher cancer mortality (P trend < 0.11), but the serum DHA or AA concentrations and the serum DHA:AA ratio were not (all P trend > 0.37). With regard to site-specific cancers, lower serum EPA:AA ratio was associated with a higher risk of death from liver cancer. However, no such associations were detected for deaths from other cancers. Conclusions: These findings suggest that decreased level of the serum EPA:AA ratio is a significant risk factor for cancer death in the general Japanese population.
AB - Background: Whether the intake of eicosapentaenoic acid (EPA) or arachidonic acid (AA) affects the risk of cancer remains unclear, and the association between the serum EPA:AA ratio and cancer risk has not been fully evaluated in general populations. Methods: A total of 3098 community-dwelling subjects aged ≥40 years were followed up for 9.6 years (2002-2012). The levels of the serum EPA:AA ratio were categorized into quartiles (< 0.29, 0.29-0.41, 0.42-0.60, and > 0.60). The risk estimates were computed using a Cox proportional hazards model. The same analyses were conducted for the serum docosahexaenoic acid to arachidonic acid (DHA:AA) ratio and individual fatty acid concentrations. Results: During the follow-up period, 121 subjects died of cancer. Age- and sex-adjusted cancer mortality increased with lower serum EPA:AA ratio levels (P trend < 0.05). In the multivariable-adjusted analysis, the subjects in the first quartile of the serum EPA:AA ratio had a 1.93-fold (95% confidence interval, 1.15-3.22) greater risk of cancer death than those in the fourth quartile. Lower serum EPA concentrations were marginally associated with higher cancer mortality (P trend < 0.11), but the serum DHA or AA concentrations and the serum DHA:AA ratio were not (all P trend > 0.37). With regard to site-specific cancers, lower serum EPA:AA ratio was associated with a higher risk of death from liver cancer. However, no such associations were detected for deaths from other cancers. Conclusions: These findings suggest that decreased level of the serum EPA:AA ratio is a significant risk factor for cancer death in the general Japanese population.
UR - http://www.scopus.com/inward/record.url?scp=85030778264&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85030778264&partnerID=8YFLogxK
U2 - 10.1016/j.je.2017.01.004
DO - 10.1016/j.je.2017.01.004
M3 - Article
C2 - 28669629
AN - SCOPUS:85030778264
VL - 27
SP - 578
EP - 583
JO - Journal of Epidemiology
JF - Journal of Epidemiology
SN - 0917-5040
IS - 12
ER -