The relationship between cyclin B1 overexpression and lymph node metastasis in human colorectal cancer

Daisuke Korenaga, Fumio Takesue, Mitsuhiro Yasuda, Masayuki Honda, Tadahiro Nozoe, Sadaaki Inutsuka

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Background. Although the molecular and biologic changes in G1/S cyclins have been well characterized, alterations in G2/M cydin and its possible roles in cell proliferation and metastatic behavior remain to be elucidated. Methods. The cyclin B1 expression immunohistochemically determined in 109 patients with colorectal cancer was investigated from the standpoints of tumor invasion, lymph node metastasis, and prognosis. These findings were analyzed in relation to the growth fractions determined with Ki-67 and proliferating cell nuclear antigen and to the expression of p53 protein. Results. A positive cyclin B1 expression was found in 62 (56.8%) of 109 patients. Tumors with cyclin B1 overexpression did not involve any lymph node, did not permeate the lymphatics, did not invade the blood vessels, and tended to be of Dukes' stage B. Those characterized by a lower expression of cyclin B1 protein frequently metastasized to the lymph nodes, showed lymphatic permeation or vessel invasion, and tended to be of Dukes' stages C or D. The overexpression of cyclin B1 showed no significant correlation with proliferative activities determined by means of Ki-67 or proliferating cell nuclear antigen or with the expression of p53 protein. Although the cyclin B1-positive group seemed to survive longer in comparison with the cyclin B1-negative group, the difference was not statistically significant. In a logistic regression analysis the cyclin B1 expression proved to be a significant factor related to the occurrence of lymph node metastasis, as did tumor size and curability of disease. Conclusions. These findings suggest a close correlation between a lack of cyclin B1 immunostaining and a stronger metastatic behavior in colorectal cancer. This inverse relationship was not ascribed to a mere consequence of cell proliferation but rather to organ specificity, heterogeneity, or an uncontrolled cyclin B1 expression probably caused by the deregulation of G2/M transition.

Original languageEnglish
Pages (from-to)S114-S120
JournalSurgery
Volume131
Issue number1 SUPPL.
DOIs
Publication statusPublished - Jan 1 2002

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Cyclin B1
Colorectal Neoplasms
Lymph Nodes
Neoplasm Metastasis
Proliferating Cell Nuclear Antigen
Cyclin G1
Cell Proliferation
Neoplasms
Organ Specificity
Proteins
Blood Vessels
Logistic Models
Regression Analysis

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

Korenaga, D., Takesue, F., Yasuda, M., Honda, M., Nozoe, T., & Inutsuka, S. (2002). The relationship between cyclin B1 overexpression and lymph node metastasis in human colorectal cancer. Surgery, 131(1 SUPPL.), S114-S120. https://doi.org/10.1067/msy.2002.119362

The relationship between cyclin B1 overexpression and lymph node metastasis in human colorectal cancer. / Korenaga, Daisuke; Takesue, Fumio; Yasuda, Mitsuhiro; Honda, Masayuki; Nozoe, Tadahiro; Inutsuka, Sadaaki.

In: Surgery, Vol. 131, No. 1 SUPPL., 01.01.2002, p. S114-S120.

Research output: Contribution to journalArticle

Korenaga, D, Takesue, F, Yasuda, M, Honda, M, Nozoe, T & Inutsuka, S 2002, 'The relationship between cyclin B1 overexpression and lymph node metastasis in human colorectal cancer', Surgery, vol. 131, no. 1 SUPPL., pp. S114-S120. https://doi.org/10.1067/msy.2002.119362
Korenaga D, Takesue F, Yasuda M, Honda M, Nozoe T, Inutsuka S. The relationship between cyclin B1 overexpression and lymph node metastasis in human colorectal cancer. Surgery. 2002 Jan 1;131(1 SUPPL.):S114-S120. https://doi.org/10.1067/msy.2002.119362
Korenaga, Daisuke ; Takesue, Fumio ; Yasuda, Mitsuhiro ; Honda, Masayuki ; Nozoe, Tadahiro ; Inutsuka, Sadaaki. / The relationship between cyclin B1 overexpression and lymph node metastasis in human colorectal cancer. In: Surgery. 2002 ; Vol. 131, No. 1 SUPPL. pp. S114-S120.
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abstract = "Background. Although the molecular and biologic changes in G1/S cyclins have been well characterized, alterations in G2/M cydin and its possible roles in cell proliferation and metastatic behavior remain to be elucidated. Methods. The cyclin B1 expression immunohistochemically determined in 109 patients with colorectal cancer was investigated from the standpoints of tumor invasion, lymph node metastasis, and prognosis. These findings were analyzed in relation to the growth fractions determined with Ki-67 and proliferating cell nuclear antigen and to the expression of p53 protein. Results. A positive cyclin B1 expression was found in 62 (56.8{\%}) of 109 patients. Tumors with cyclin B1 overexpression did not involve any lymph node, did not permeate the lymphatics, did not invade the blood vessels, and tended to be of Dukes' stage B. Those characterized by a lower expression of cyclin B1 protein frequently metastasized to the lymph nodes, showed lymphatic permeation or vessel invasion, and tended to be of Dukes' stages C or D. The overexpression of cyclin B1 showed no significant correlation with proliferative activities determined by means of Ki-67 or proliferating cell nuclear antigen or with the expression of p53 protein. Although the cyclin B1-positive group seemed to survive longer in comparison with the cyclin B1-negative group, the difference was not statistically significant. In a logistic regression analysis the cyclin B1 expression proved to be a significant factor related to the occurrence of lymph node metastasis, as did tumor size and curability of disease. Conclusions. These findings suggest a close correlation between a lack of cyclin B1 immunostaining and a stronger metastatic behavior in colorectal cancer. This inverse relationship was not ascribed to a mere consequence of cell proliferation but rather to organ specificity, heterogeneity, or an uncontrolled cyclin B1 expression probably caused by the deregulation of G2/M transition.",
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N2 - Background. Although the molecular and biologic changes in G1/S cyclins have been well characterized, alterations in G2/M cydin and its possible roles in cell proliferation and metastatic behavior remain to be elucidated. Methods. The cyclin B1 expression immunohistochemically determined in 109 patients with colorectal cancer was investigated from the standpoints of tumor invasion, lymph node metastasis, and prognosis. These findings were analyzed in relation to the growth fractions determined with Ki-67 and proliferating cell nuclear antigen and to the expression of p53 protein. Results. A positive cyclin B1 expression was found in 62 (56.8%) of 109 patients. Tumors with cyclin B1 overexpression did not involve any lymph node, did not permeate the lymphatics, did not invade the blood vessels, and tended to be of Dukes' stage B. Those characterized by a lower expression of cyclin B1 protein frequently metastasized to the lymph nodes, showed lymphatic permeation or vessel invasion, and tended to be of Dukes' stages C or D. The overexpression of cyclin B1 showed no significant correlation with proliferative activities determined by means of Ki-67 or proliferating cell nuclear antigen or with the expression of p53 protein. Although the cyclin B1-positive group seemed to survive longer in comparison with the cyclin B1-negative group, the difference was not statistically significant. In a logistic regression analysis the cyclin B1 expression proved to be a significant factor related to the occurrence of lymph node metastasis, as did tumor size and curability of disease. Conclusions. These findings suggest a close correlation between a lack of cyclin B1 immunostaining and a stronger metastatic behavior in colorectal cancer. This inverse relationship was not ascribed to a mere consequence of cell proliferation but rather to organ specificity, heterogeneity, or an uncontrolled cyclin B1 expression probably caused by the deregulation of G2/M transition.

AB - Background. Although the molecular and biologic changes in G1/S cyclins have been well characterized, alterations in G2/M cydin and its possible roles in cell proliferation and metastatic behavior remain to be elucidated. Methods. The cyclin B1 expression immunohistochemically determined in 109 patients with colorectal cancer was investigated from the standpoints of tumor invasion, lymph node metastasis, and prognosis. These findings were analyzed in relation to the growth fractions determined with Ki-67 and proliferating cell nuclear antigen and to the expression of p53 protein. Results. A positive cyclin B1 expression was found in 62 (56.8%) of 109 patients. Tumors with cyclin B1 overexpression did not involve any lymph node, did not permeate the lymphatics, did not invade the blood vessels, and tended to be of Dukes' stage B. Those characterized by a lower expression of cyclin B1 protein frequently metastasized to the lymph nodes, showed lymphatic permeation or vessel invasion, and tended to be of Dukes' stages C or D. The overexpression of cyclin B1 showed no significant correlation with proliferative activities determined by means of Ki-67 or proliferating cell nuclear antigen or with the expression of p53 protein. Although the cyclin B1-positive group seemed to survive longer in comparison with the cyclin B1-negative group, the difference was not statistically significant. In a logistic regression analysis the cyclin B1 expression proved to be a significant factor related to the occurrence of lymph node metastasis, as did tumor size and curability of disease. Conclusions. These findings suggest a close correlation between a lack of cyclin B1 immunostaining and a stronger metastatic behavior in colorectal cancer. This inverse relationship was not ascribed to a mere consequence of cell proliferation but rather to organ specificity, heterogeneity, or an uncontrolled cyclin B1 expression probably caused by the deregulation of G2/M transition.

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