The relationship between serum lipoprotein (a) and restenosis after initial elective percutaneous transluminal coronary angioplasty

Kohji Tenda, Tetsunori Saikawa, Toshihiro Maeda, Yasufumi Sato, Hidetoshi Yonemochi, Nobuo Shimoyama, Satoshi Aragaki, Masahide Hara, Ryosaburo Takaki, Hiroko Niwa, Takeshi Inoue, Toru Maruyama

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

The purpose of this study was to elucidate the possible link between lipoprotein(a) (Lp(a)) and the occurrence of restenosis after initial elective percutaneous transluminal coronary angiopasty (PTCA). Serum lipids, including Lp(a), total cholesterol, triglyceride, HDL-cholesterol, LDL-cholesterol, apolipoprotein A-I (Apo A-I), and apolipoprotein B (Apo B), and the Apo B/Apo A-I ratio were examined in 63 consecutive patients (41 men and 22 women, average age 63±8 years) who underwent initial elective PTCA in our department. Forty two target lesions were in left anterior descending, 10 were in left circumflex and 11 were in right coronary branches. Restenosis was observed in 22 patients (35%) 6.4±2.6 months after PTCA. The serum Lp(a) level was significantly higher in the restenosis group than in the non-restenosis group (38.0 vs 19.9 mg/dl, p<0.05). A significant correlation was observed between serum Lp(a) levels and the degree of % restenosis after PTCA (r=0.557, p<0.001). However, other lipids showed no significant relationship to restenosis. In addition, the % stenosis before PTCA was found to be related to the occurrence of restenosis after successful PTCA. We conclude that the serum Lp(a) level has a close correlation with the degree of % restenosis after PTCA, and may be a useful index for predicting the possibility of restenosis after PTCA, especially in patients with an Lp(a) level above 30 mg/dl.

Original languageEnglish
Pages (from-to)789-795
Number of pages7
JournalJAPANESE CIRCULATION JOURNAL
Volume57
Issue number8
DOIs
Publication statusPublished - Jan 1 1993

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Lipoprotein(a)
Coronary Balloon Angioplasty
Serum
Apolipoprotein A-I
Apolipoproteins B
Lipids
LDL Cholesterol
HDL Cholesterol
Pathologic Constriction
Triglycerides
Cholesterol

All Science Journal Classification (ASJC) codes

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

The relationship between serum lipoprotein (a) and restenosis after initial elective percutaneous transluminal coronary angioplasty. / Tenda, Kohji; Saikawa, Tetsunori; Maeda, Toshihiro; Sato, Yasufumi; Yonemochi, Hidetoshi; Shimoyama, Nobuo; Aragaki, Satoshi; Hara, Masahide; Takaki, Ryosaburo; Niwa, Hiroko; Inoue, Takeshi; Maruyama, Toru.

In: JAPANESE CIRCULATION JOURNAL, Vol. 57, No. 8, 01.01.1993, p. 789-795.

Research output: Contribution to journalArticle

Tenda, K, Saikawa, T, Maeda, T, Sato, Y, Yonemochi, H, Shimoyama, N, Aragaki, S, Hara, M, Takaki, R, Niwa, H, Inoue, T & Maruyama, T 1993, 'The relationship between serum lipoprotein (a) and restenosis after initial elective percutaneous transluminal coronary angioplasty', JAPANESE CIRCULATION JOURNAL, vol. 57, no. 8, pp. 789-795. https://doi.org/10.1253/jcj.57.789
Tenda, Kohji ; Saikawa, Tetsunori ; Maeda, Toshihiro ; Sato, Yasufumi ; Yonemochi, Hidetoshi ; Shimoyama, Nobuo ; Aragaki, Satoshi ; Hara, Masahide ; Takaki, Ryosaburo ; Niwa, Hiroko ; Inoue, Takeshi ; Maruyama, Toru. / The relationship between serum lipoprotein (a) and restenosis after initial elective percutaneous transluminal coronary angioplasty. In: JAPANESE CIRCULATION JOURNAL. 1993 ; Vol. 57, No. 8. pp. 789-795.
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abstract = "The purpose of this study was to elucidate the possible link between lipoprotein(a) (Lp(a)) and the occurrence of restenosis after initial elective percutaneous transluminal coronary angiopasty (PTCA). Serum lipids, including Lp(a), total cholesterol, triglyceride, HDL-cholesterol, LDL-cholesterol, apolipoprotein A-I (Apo A-I), and apolipoprotein B (Apo B), and the Apo B/Apo A-I ratio were examined in 63 consecutive patients (41 men and 22 women, average age 63±8 years) who underwent initial elective PTCA in our department. Forty two target lesions were in left anterior descending, 10 were in left circumflex and 11 were in right coronary branches. Restenosis was observed in 22 patients (35{\%}) 6.4±2.6 months after PTCA. The serum Lp(a) level was significantly higher in the restenosis group than in the non-restenosis group (38.0 vs 19.9 mg/dl, p<0.05). A significant correlation was observed between serum Lp(a) levels and the degree of {\%} restenosis after PTCA (r=0.557, p<0.001). However, other lipids showed no significant relationship to restenosis. In addition, the {\%} stenosis before PTCA was found to be related to the occurrence of restenosis after successful PTCA. We conclude that the serum Lp(a) level has a close correlation with the degree of {\%} restenosis after PTCA, and may be a useful index for predicting the possibility of restenosis after PTCA, especially in patients with an Lp(a) level above 30 mg/dl.",
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AU - Tenda, Kohji

AU - Saikawa, Tetsunori

AU - Maeda, Toshihiro

AU - Sato, Yasufumi

AU - Yonemochi, Hidetoshi

AU - Shimoyama, Nobuo

AU - Aragaki, Satoshi

AU - Hara, Masahide

AU - Takaki, Ryosaburo

AU - Niwa, Hiroko

AU - Inoue, Takeshi

AU - Maruyama, Toru

PY - 1993/1/1

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N2 - The purpose of this study was to elucidate the possible link between lipoprotein(a) (Lp(a)) and the occurrence of restenosis after initial elective percutaneous transluminal coronary angiopasty (PTCA). Serum lipids, including Lp(a), total cholesterol, triglyceride, HDL-cholesterol, LDL-cholesterol, apolipoprotein A-I (Apo A-I), and apolipoprotein B (Apo B), and the Apo B/Apo A-I ratio were examined in 63 consecutive patients (41 men and 22 women, average age 63±8 years) who underwent initial elective PTCA in our department. Forty two target lesions were in left anterior descending, 10 were in left circumflex and 11 were in right coronary branches. Restenosis was observed in 22 patients (35%) 6.4±2.6 months after PTCA. The serum Lp(a) level was significantly higher in the restenosis group than in the non-restenosis group (38.0 vs 19.9 mg/dl, p<0.05). A significant correlation was observed between serum Lp(a) levels and the degree of % restenosis after PTCA (r=0.557, p<0.001). However, other lipids showed no significant relationship to restenosis. In addition, the % stenosis before PTCA was found to be related to the occurrence of restenosis after successful PTCA. We conclude that the serum Lp(a) level has a close correlation with the degree of % restenosis after PTCA, and may be a useful index for predicting the possibility of restenosis after PTCA, especially in patients with an Lp(a) level above 30 mg/dl.

AB - The purpose of this study was to elucidate the possible link between lipoprotein(a) (Lp(a)) and the occurrence of restenosis after initial elective percutaneous transluminal coronary angiopasty (PTCA). Serum lipids, including Lp(a), total cholesterol, triglyceride, HDL-cholesterol, LDL-cholesterol, apolipoprotein A-I (Apo A-I), and apolipoprotein B (Apo B), and the Apo B/Apo A-I ratio were examined in 63 consecutive patients (41 men and 22 women, average age 63±8 years) who underwent initial elective PTCA in our department. Forty two target lesions were in left anterior descending, 10 were in left circumflex and 11 were in right coronary branches. Restenosis was observed in 22 patients (35%) 6.4±2.6 months after PTCA. The serum Lp(a) level was significantly higher in the restenosis group than in the non-restenosis group (38.0 vs 19.9 mg/dl, p<0.05). A significant correlation was observed between serum Lp(a) levels and the degree of % restenosis after PTCA (r=0.557, p<0.001). However, other lipids showed no significant relationship to restenosis. In addition, the % stenosis before PTCA was found to be related to the occurrence of restenosis after successful PTCA. We conclude that the serum Lp(a) level has a close correlation with the degree of % restenosis after PTCA, and may be a useful index for predicting the possibility of restenosis after PTCA, especially in patients with an Lp(a) level above 30 mg/dl.

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