The Relationship between Water Structure and Blood Compatibility in Poly(2-methoxyethyl Acrylate) (PMEA) Analogues

Kazuhiro Sato, Shingo Kobayashi, Miho Kusakari, Shogo Watahiki, Masahiko Oikawa, Takashi Hoshiba, Masaru Tanaka

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)

Abstract

Six types of poly(2-methoxyethyl acrylate) (PMEA) analogues were synthesized and the water structure in the hydrated polymers was characterized using differential scanning calorimetry (DSC). The hydrated PMEA analogues exhibited the different amounts of intermediate water. Non-thrombogenicity evaluation was performed on PMEA analogues for platelet adhesion and protein adsorption. Platelet adhesion was suppressed on PMEA analogues. In addition, the protein adsorption and deformation were suppressed by increasing the amount of intermediate water. This study demonstrates that the amount of intermediate water might play a key role in expressing the blood compatibility of polymeric materials.

Original languageEnglish
Pages (from-to)1296-1303
Number of pages8
JournalMacromolecular Bioscience
Volume15
Issue number9
DOIs
Publication statusPublished - Sep 1 2015

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

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