The role of γδ T cells in priming macrophages to produce tumor necrosis factor‐α

Hitoshi Nishimura, Masashi Emoto, Kenji Hiromatsu, Shunsuke Yamamoto, Keiko Matsuura, Hiroshi Gomi, Toshio Ikeda, Shigeyoshi Itohara, Yasunobu Yoshikai

    Research output: Contribution to journalArticle

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    Abstract

    The secretion of tumor necrosis factor (TNF)‐α from macrophages is regulated by both priming and triggering signals. We found that macrophages from mice lacking γδ T cells [T cell receptor (TCR) δ−/‐ mice], which lack the gene encoding the δ chain, produced only small amounts of TNF‐α in response to lipopolysaccharide (LPS) and showed a reduced level of expression of CD14. Pre‐incubation of macrophages from TCR δ‐/‐ mice with γδ T cells from their TCR δ+/‐ littermates restored their capacity to produce TNF‐α in response to LPS. The priming activity of γδ T cells was in part inhibited by neutralizing anti‐interferon (IFN)‐γ monoclonal antibodies. Collectively, these results suggest that γδ T cells play a role in priming macrophages to a steady state of activation via IFN‐γ secretion, which allows them to produce TNF‐α when exposed to LPS.

    Original languageEnglish
    Pages (from-to)1465-1468
    Number of pages4
    JournalEuropean Journal of Immunology
    Volume25
    Issue number5
    DOIs
    Publication statusPublished - Jan 1 1995

    Fingerprint

    Tumor Necrosis Factor-alpha
    T-Cell Antigen Receptor
    Macrophages
    T-Lymphocytes
    Lipopolysaccharides
    Monoclonal Antibodies
    Genes

    All Science Journal Classification (ASJC) codes

    • Immunology and Allergy
    • Immunology

    Cite this

    Nishimura, H., Emoto, M., Hiromatsu, K., Yamamoto, S., Matsuura, K., Gomi, H., ... Yoshikai, Y. (1995). The role of γδ T cells in priming macrophages to produce tumor necrosis factor‐α. European Journal of Immunology, 25(5), 1465-1468. https://doi.org/10.1002/eji.1830250551

    The role of γδ T cells in priming macrophages to produce tumor necrosis factor‐α. / Nishimura, Hitoshi; Emoto, Masashi; Hiromatsu, Kenji; Yamamoto, Shunsuke; Matsuura, Keiko; Gomi, Hiroshi; Ikeda, Toshio; Itohara, Shigeyoshi; Yoshikai, Yasunobu.

    In: European Journal of Immunology, Vol. 25, No. 5, 01.01.1995, p. 1465-1468.

    Research output: Contribution to journalArticle

    Nishimura, H, Emoto, M, Hiromatsu, K, Yamamoto, S, Matsuura, K, Gomi, H, Ikeda, T, Itohara, S & Yoshikai, Y 1995, 'The role of γδ T cells in priming macrophages to produce tumor necrosis factor‐α', European Journal of Immunology, vol. 25, no. 5, pp. 1465-1468. https://doi.org/10.1002/eji.1830250551
    Nishimura H, Emoto M, Hiromatsu K, Yamamoto S, Matsuura K, Gomi H et al. The role of γδ T cells in priming macrophages to produce tumor necrosis factor‐α. European Journal of Immunology. 1995 Jan 1;25(5):1465-1468. https://doi.org/10.1002/eji.1830250551
    Nishimura, Hitoshi ; Emoto, Masashi ; Hiromatsu, Kenji ; Yamamoto, Shunsuke ; Matsuura, Keiko ; Gomi, Hiroshi ; Ikeda, Toshio ; Itohara, Shigeyoshi ; Yoshikai, Yasunobu. / The role of γδ T cells in priming macrophages to produce tumor necrosis factor‐α. In: European Journal of Immunology. 1995 ; Vol. 25, No. 5. pp. 1465-1468.
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