The role of an octacalcium phosphate in the re-formation of infraspinatus tendon insertion

Yoshiaki Itoigawa, Osamu Suzuki, Hirotaka Sano, Takahisa Anada, Takuto Handa, Taku Hatta, Yoshiyuki Kuwahara, Atsushi Takahashi, Yushi Ezoe, Kazuo Kaneko, Eiji Itoi

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: To improve the success rate of rotator cuff repair, we investigated whether octacalcium phosphate (OCP) with gelatin (Gel) vehicle had a positive effect on tendon-to-bone healing. Methods: We assessed the histologic characteristics of the tendon-to-bone healing using the rabbit rotator cuff repair model. We divided the shoulders into 3 groups: control (without OCP/Gel composite), OCP/Gel composite (OCP+group), and Gel alone without OCP (Gel group) to evaluate the effectiveness of gelatin. Results: Both the number of newly formed tendon fibers and the Sharpey fibers at the repair site increased in the OCP+group compared with those in the other 2 groups on hematoxylin-eosin staining (P<.05). On immunohistochemical evaluation, both the bone and the fibers in the OCP+group demonstrated that type I collagen was picked up, whereas the newly formed tendon fibers and Sharpey fibers revealed type III collagen. Conclusion: Treatment with OCP made collagen fibers and the Sharpey fibers, constituted by type I and type III collagens, increase at the tendon-to-bone insertion. It might be beneficial for the healing of rotator cuff tendon to bone.

Original languageEnglish
Pages (from-to)e175-e184
JournalJournal of Shoulder and Elbow Surgery
Volume24
Issue number7
DOIs
Publication statusPublished - Jul 1 2015
Externally publishedYes

Fingerprint

Rotator Cuff
Tendons
Gelatin
Bone and Bones
Collagen Type III
Collagen Type I
octacalcium phosphate
Hematoxylin
Eosine Yellowish-(YS)
Collagen
Staining and Labeling
Rabbits
Control Groups

All Science Journal Classification (ASJC) codes

  • Surgery
  • Orthopedics and Sports Medicine

Cite this

The role of an octacalcium phosphate in the re-formation of infraspinatus tendon insertion. / Itoigawa, Yoshiaki; Suzuki, Osamu; Sano, Hirotaka; Anada, Takahisa; Handa, Takuto; Hatta, Taku; Kuwahara, Yoshiyuki; Takahashi, Atsushi; Ezoe, Yushi; Kaneko, Kazuo; Itoi, Eiji.

In: Journal of Shoulder and Elbow Surgery, Vol. 24, No. 7, 01.07.2015, p. e175-e184.

Research output: Contribution to journalArticle

Itoigawa, Y, Suzuki, O, Sano, H, Anada, T, Handa, T, Hatta, T, Kuwahara, Y, Takahashi, A, Ezoe, Y, Kaneko, K & Itoi, E 2015, 'The role of an octacalcium phosphate in the re-formation of infraspinatus tendon insertion', Journal of Shoulder and Elbow Surgery, vol. 24, no. 7, pp. e175-e184. https://doi.org/10.1016/j.jse.2015.01.011
Itoigawa, Yoshiaki ; Suzuki, Osamu ; Sano, Hirotaka ; Anada, Takahisa ; Handa, Takuto ; Hatta, Taku ; Kuwahara, Yoshiyuki ; Takahashi, Atsushi ; Ezoe, Yushi ; Kaneko, Kazuo ; Itoi, Eiji. / The role of an octacalcium phosphate in the re-formation of infraspinatus tendon insertion. In: Journal of Shoulder and Elbow Surgery. 2015 ; Vol. 24, No. 7. pp. e175-e184.
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