The role of cullin 5-containing ubiquitin ligases

Fumihiko Okumura; Akiko Joo-Okumura; Kunio Nakatsukasa; Takumi Kamura

doi:10.1186/s13008-016-0016-3

The role of cullin 5-containing ubiquitin ligases

Fumihiko Okumura, Akiko Joo-Okumura, Kunio Nakatsukasa, Takumi Kamura

Research output: Contribution to journal › Review article › peer-review

47 Citations (Scopus)

Abstract

The suppressor of cytokine signaling (SOCS) box consists of the BC box and the cullin 5 (Cul5) box, which interact with Elongin BC and Cul5, respectively. SOCS box-containing proteins have ubiquitin ligase activity mediated by the formation of a complex with the scaffold protein Cul5 and the RING domain protein Rbx2, and are thereby members of the cullin RING ligase superfamily. Cul5-type ubiquitin ligases have a variety of substrates that are targeted for polyubiquitination and proteasomal degradation. Here, we review the current knowledge on the identification of Cul5 and the regulation of its expression, as well as the signaling pathways regulated by Cul5 and how viruses highjack the Cul5 system to overcome antiviral responses.

Original language	English
Article number	1
Journal	Cell Division
Volume	11
Issue number	1
DOIs	https://doi.org/10.1186/s13008-016-0016-3
Publication status	Published - Mar 9 2016
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Biology
Cell Biology

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10.1186/s13008-016-0016-3

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title = "The role of cullin 5-containing ubiquitin ligases",

abstract = "The suppressor of cytokine signaling (SOCS) box consists of the BC box and the cullin 5 (Cul5) box, which interact with Elongin BC and Cul5, respectively. SOCS box-containing proteins have ubiquitin ligase activity mediated by the formation of a complex with the scaffold protein Cul5 and the RING domain protein Rbx2, and are thereby members of the cullin RING ligase superfamily. Cul5-type ubiquitin ligases have a variety of substrates that are targeted for polyubiquitination and proteasomal degradation. Here, we review the current knowledge on the identification of Cul5 and the regulation of its expression, as well as the signaling pathways regulated by Cul5 and how viruses highjack the Cul5 system to overcome antiviral responses.",

author = "Fumihiko Okumura and Akiko Joo-Okumura and Kunio Nakatsukasa and Takumi Kamura",

note = "Funding Information: This work was supported by JSPS KAKENHI Grant Numbers 25291023 (to F.O. and T.K.), 25860043 (to F.O.), and 24112006 (to T.K.), a Grant‑in‑Aid from Scien‑ tific Research on Innovative Areas, and Grants from the Ministry of Education, Science, Sports, and Culture of Japan. Publisher Copyright: {\textcopyright} 2016 Okumura et al.",

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doi = "10.1186/s13008-016-0016-3",

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AU - Joo-Okumura, Akiko

AU - Nakatsukasa, Kunio

AU - Kamura, Takumi

N1 - Funding Information: This work was supported by JSPS KAKENHI Grant Numbers 25291023 (to F.O. and T.K.), 25860043 (to F.O.), and 24112006 (to T.K.), a Grant‑in‑Aid from Scien‑ tific Research on Innovative Areas, and Grants from the Ministry of Education, Science, Sports, and Culture of Japan. Publisher Copyright: © 2016 Okumura et al.

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N2 - The suppressor of cytokine signaling (SOCS) box consists of the BC box and the cullin 5 (Cul5) box, which interact with Elongin BC and Cul5, respectively. SOCS box-containing proteins have ubiquitin ligase activity mediated by the formation of a complex with the scaffold protein Cul5 and the RING domain protein Rbx2, and are thereby members of the cullin RING ligase superfamily. Cul5-type ubiquitin ligases have a variety of substrates that are targeted for polyubiquitination and proteasomal degradation. Here, we review the current knowledge on the identification of Cul5 and the regulation of its expression, as well as the signaling pathways regulated by Cul5 and how viruses highjack the Cul5 system to overcome antiviral responses.

AB - The suppressor of cytokine signaling (SOCS) box consists of the BC box and the cullin 5 (Cul5) box, which interact with Elongin BC and Cul5, respectively. SOCS box-containing proteins have ubiquitin ligase activity mediated by the formation of a complex with the scaffold protein Cul5 and the RING domain protein Rbx2, and are thereby members of the cullin RING ligase superfamily. Cul5-type ubiquitin ligases have a variety of substrates that are targeted for polyubiquitination and proteasomal degradation. Here, we review the current knowledge on the identification of Cul5 and the regulation of its expression, as well as the signaling pathways regulated by Cul5 and how viruses highjack the Cul5 system to overcome antiviral responses.

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The role of cullin 5-containing ubiquitin ligases

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