The role of DNA repair glycosylase OGG1 in intrahepatic cholangiocarcinoma

Kazuhito Sakata, Tomoharu Yoshizumi, Takuma Izumi, Masahiro Shimokawa, Shinji Itoh, Toru Ikegami, Noboru Harada, Takeo Toshima, Yohei Mano, Masaki Mori

Research output: Contribution to journalArticle

Abstract

Background/Aim: The effects of oxidative stress on various carcinomas were reported in previous studies, but those in intrahepatic cholangiocarcinoma (ICC) have not been fully elucidated. The purpose of this study was, thus, to reveal the effects of oxidative DNA damage and repair enzymes on ICC. Materials and Methods: The levels of 8-hydroxydeoxyguanosine (8-OHdG) and 8-OHdG DNA glycosylase (OGG1) were immunohistochemically evaluated in specimens resected from 63 patients with ICC. Results: Low OGG1 expression was related to tumour depth T4 (p=0.04), venous invasion (p=0.0005), lymphatic vessel invasion (p=0.03), and perineural invasion (p=0.03). Compared to the high-OGG1-expression group, patients with low OGG1 expression had a significantly poorer prognosis (overall survival: p=0.04, recurrence-free survival: p=0.02). Unlike for OGG1, the expression levels of 8-OHdG showed no association with prognosis. Conclusion: Oxidative DNA damage and DNA repair enzymes may be closely related to ICC progression.

Original languageEnglish
Pages (from-to)3241-3248
Number of pages8
JournalAnticancer research
Volume39
Issue number6
DOIs
Publication statusPublished - Jan 1 2019

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DNA Glycosylases
Cholangiocarcinoma
DNA Repair
DNA Repair Enzymes
DNA Damage
Lymphatic Vessels
Survival
Oxidative Stress
Carcinoma
Recurrence
Neoplasms

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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The role of DNA repair glycosylase OGG1 in intrahepatic cholangiocarcinoma. / Sakata, Kazuhito; Yoshizumi, Tomoharu; Izumi, Takuma; Shimokawa, Masahiro; Itoh, Shinji; Ikegami, Toru; Harada, Noboru; Toshima, Takeo; Mano, Yohei; Mori, Masaki.

In: Anticancer research, Vol. 39, No. 6, 01.01.2019, p. 3241-3248.

Research output: Contribution to journalArticle

Sakata, Kazuhito ; Yoshizumi, Tomoharu ; Izumi, Takuma ; Shimokawa, Masahiro ; Itoh, Shinji ; Ikegami, Toru ; Harada, Noboru ; Toshima, Takeo ; Mano, Yohei ; Mori, Masaki. / The role of DNA repair glycosylase OGG1 in intrahepatic cholangiocarcinoma. In: Anticancer research. 2019 ; Vol. 39, No. 6. pp. 3241-3248.
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AU - Ikegami, Toru

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AU - Mori, Masaki

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