TY - JOUR
T1 - The role of epidermal cells in the induction of delayed-type hypersensitivity to alloantigens
AU - Tamaki, K.
AU - Furue, M.
N1 - Funding Information:
Manuscript received August 8, 1984; accepted for publication December 31, 1984. Supported in part by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture, and grants of Lydia O'Leary Memorial Foundation. Reprint requests to: Kunihiko Tamaki, M.D., Department of Dermatology, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113, J apan. Abbreviations: DTH: delayed-type hypersensitivity EC: epidermal cell(s) LC: Langerhans cells MHC: major histocompatibility complex SC: spleen cells TNCB: trinitrochlorobenzene
PY - 1985
Y1 - 1985
N2 - Recent studies suggest that skin graft rejection and delayed-type hypersensitivity (DTH) are different manifestations of the same mechanism. In order to investigate the alloantigenicity of epidermal cells and epidermal Langerhans cells (LC), we used epidermal cell suspensions; experiments were performed to try to induce DTH to alloantigens by the subcutaneous administration of epidermal cells. Our study establishes the precise conditions for the induction of DTH response to alloantigens using epidermal cells. Transfer experiments have shown that effector cells were Thy-1+, Lyt-1+, and Lyt-2- cells. Furthermore, the experiments using congenic strains of mice and grafted skin revealed the contribution of gene products coded by MHC and non-MHC, and also the epidermal LC in the induction of DTH response.
AB - Recent studies suggest that skin graft rejection and delayed-type hypersensitivity (DTH) are different manifestations of the same mechanism. In order to investigate the alloantigenicity of epidermal cells and epidermal Langerhans cells (LC), we used epidermal cell suspensions; experiments were performed to try to induce DTH to alloantigens by the subcutaneous administration of epidermal cells. Our study establishes the precise conditions for the induction of DTH response to alloantigens using epidermal cells. Transfer experiments have shown that effector cells were Thy-1+, Lyt-1+, and Lyt-2- cells. Furthermore, the experiments using congenic strains of mice and grafted skin revealed the contribution of gene products coded by MHC and non-MHC, and also the epidermal LC in the induction of DTH response.
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U2 - 10.1111/1523-1747.ep12274517
DO - 10.1111/1523-1747.ep12274517
M3 - Article
C2 - 3891874
AN - SCOPUS:0021795889
SN - 0022-202X
VL - 85
SP - 20
EP - 24
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
IS - 1
ER -