The role of glucocorticoids and retinoic acid in the pituitary endocrine cell differentiation

Kinji Inoue; Hideki Goda; Chihiro Mogi; Mikio Tomida; Shinobu Tsurugano

The role of glucocorticoids and retinoic acid in the pituitary endocrine cell differentiation

Kinji Inoue, Hideki Goda, Chihiro Mogi, Mikio Tomida, Shinobu Tsurugano

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Anterior pituitary hormones are individually produced and secreted by five types of glandular cells. These specialized types of cells, which produce different hormones, are believed to arise from common stem cells. However, the mechanism by which these anterior pituitary glandular cells differentiate is still under discussion. Recent advances in molecular biology have revealed many transcription factors that promote pituitary hormone gene expression. The Pit-1 gene is an example of such a transcription factor. The Pit-1 gene is known to affect growth hormone (GH), prolactin (PRL), and thyrotropin (TSH) cell differentiation. This suggests that all three cell types may arise from a common progenitor cell. However, how these cell types differentiate and then mature into individual cell types in the adult anterior pituitary gland is still unknown. We were especially interested in the differentiation of Pit-1 lineage cells.

Original language	English
Title of host publication	Neuroplasticity, Development, and Steroid Hormone Action
Publisher	CRC Press
Pages	73-80
Number of pages	8
ISBN (Electronic)	9781420041194
ISBN (Print)	084930962X, 9780849309625
Publication status	Published - Jan 1 2001
Externally published	Yes

All Science Journal Classification (ASJC) codes

Neuroscience(all)
Medicine(all)
Biochemistry, Genetics and Molecular Biology(all)

Cite this

@inbook{81be95c9178c4d038c5d7e63cf8a584b,

title = "The role of glucocorticoids and retinoic acid in the pituitary endocrine cell differentiation",

abstract = "Anterior pituitary hormones are individually produced and secreted by five types of glandular cells. These specialized types of cells, which produce different hormones, are believed to arise from common stem cells. However, the mechanism by which these anterior pituitary glandular cells differentiate is still under discussion. Recent advances in molecular biology have revealed many transcription factors that promote pituitary hormone gene expression. The Pit-1 gene is an example of such a transcription factor. The Pit-1 gene is known to affect growth hormone (GH), prolactin (PRL), and thyrotropin (TSH) cell differentiation. This suggests that all three cell types may arise from a common progenitor cell. However, how these cell types differentiate and then mature into individual cell types in the adult anterior pituitary gland is still unknown. We were especially interested in the differentiation of Pit-1 lineage cells.",

author = "Kinji Inoue and Hideki Goda and Chihiro Mogi and Mikio Tomida and Shinobu Tsurugano",

note = "Publisher Copyright: {\textcopyright} 2002 by CRC Press LLC.",

year = "2001",

month = jan,

day = "1",

language = "English",

isbn = "084930962X",

pages = "73--80",

booktitle = "Neuroplasticity, Development, and Steroid Hormone Action",

publisher = "CRC Press",

}

TY - CHAP

T1 - The role of glucocorticoids and retinoic acid in the pituitary endocrine cell differentiation

AU - Inoue, Kinji

AU - Goda, Hideki

AU - Mogi, Chihiro

AU - Tomida, Mikio

AU - Tsurugano, Shinobu

PY - 2001/1/1

Y1 - 2001/1/1

N2 - Anterior pituitary hormones are individually produced and secreted by five types of glandular cells. These specialized types of cells, which produce different hormones, are believed to arise from common stem cells. However, the mechanism by which these anterior pituitary glandular cells differentiate is still under discussion. Recent advances in molecular biology have revealed many transcription factors that promote pituitary hormone gene expression. The Pit-1 gene is an example of such a transcription factor. The Pit-1 gene is known to affect growth hormone (GH), prolactin (PRL), and thyrotropin (TSH) cell differentiation. This suggests that all three cell types may arise from a common progenitor cell. However, how these cell types differentiate and then mature into individual cell types in the adult anterior pituitary gland is still unknown. We were especially interested in the differentiation of Pit-1 lineage cells.

AB - Anterior pituitary hormones are individually produced and secreted by five types of glandular cells. These specialized types of cells, which produce different hormones, are believed to arise from common stem cells. However, the mechanism by which these anterior pituitary glandular cells differentiate is still under discussion. Recent advances in molecular biology have revealed many transcription factors that promote pituitary hormone gene expression. The Pit-1 gene is an example of such a transcription factor. The Pit-1 gene is known to affect growth hormone (GH), prolactin (PRL), and thyrotropin (TSH) cell differentiation. This suggests that all three cell types may arise from a common progenitor cell. However, how these cell types differentiate and then mature into individual cell types in the adult anterior pituitary gland is still unknown. We were especially interested in the differentiation of Pit-1 lineage cells.

UR - http://www.scopus.com/inward/record.url?scp=85054501433&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85054501433&partnerID=8YFLogxK

M3 - Chapter

AN - SCOPUS:85054501433

SN - 084930962X

SN - 9780849309625

SP - 73

EP - 80

BT - Neuroplasticity, Development, and Steroid Hormone Action

PB - CRC Press

ER -

The role of glucocorticoids and retinoic acid in the pituitary endocrine cell differentiation

Abstract

All Science Journal Classification (ASJC) codes

Other files and links

Fingerprint

Cite this