THE ROLE OF HLA CLASS II ANTIGENS IN THE INDUCTION OF CYTOTOXIC T LYMPHOCYTES

V. Demeŝová, M. Buc, S. Ferenĉiak, Takehiko Sasazuki, I. Shawkatová, S. PORUBSKA

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Abstract

Investigation of pairs of unrelated persons mismatched for a particular HLA‐DQB1 or ‐DPB1 gene on the induction of cytotoxic T lymphocytes (CTL) revealed that HLA‐DQ and HLA‐DP antigens provided a slight proliferative stimulus which was, however, sufficient for the generation of CTL. Monomorphic anti‐DQ and anti‐DP monoclonal antibodies abrogated the induction of cytotoxic response. The results indicate that the HLA‐DQ and HLA‐DP antigens play a similar role to HLA‐DR specificities in clinical bone marrow transplantation.

Original languageEnglish
Pages (from-to)425-434
Number of pages10
JournalInternational Journal of Immunogenetics
Volume22
Issue number6
DOIs
Publication statusPublished - Jan 1 1995

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All Science Journal Classification (ASJC) codes

  • Immunology
  • Molecular Biology
  • Genetics
  • Genetics(clinical)

Cite this

Demeŝová, V., Buc, M., Ferenĉiak, S., Sasazuki, T., Shawkatová, I., & PORUBSKA, S. (1995). THE ROLE OF HLA CLASS II ANTIGENS IN THE INDUCTION OF CYTOTOXIC T LYMPHOCYTES. International Journal of Immunogenetics, 22(6), 425-434. https://doi.org/10.1111/j.1744-313X.1995.tb00280.x