Investigation of pairs of unrelated persons mismatched for a particular HLA‐DQB1 or ‐DPB1 gene on the induction of cytotoxic T lymphocytes (CTL) revealed that HLA‐DQ and HLA‐DP antigens provided a slight proliferative stimulus which was, however, sufficient for the generation of CTL. Monomorphic anti‐DQ and anti‐DP monoclonal antibodies abrogated the induction of cytotoxic response. The results indicate that the HLA‐DQ and HLA‐DP antigens play a similar role to HLA‐DR specificities in clinical bone marrow transplantation.
|Number of pages||10|
|Journal||International Journal of Immunogenetics|
|Publication status||Published - Jan 1 1995|
All Science Journal Classification (ASJC) codes
- Molecular Biology