The role of interleukin-19 in contact hypersensitivity

Yasuyuki Fujimoto, Takashi Fujita, Nobuyuki Kuramoto, Mitsuru Kuwamura, Takeshi Izawa, Kazuhiro Nishiyama, Natsuho Yoshida, Hidemitsu Nakajima, Tadayoshi Takeuchi, Yasu Taka Azuma

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Interleukin (IL)-19 is a member of the IL-10 family of interleukins and is an immuno-modulatory cytokine produced by the main macrophages. The gastrointestinal tissues of IL-19 knockout mice show exacerbated experimental colitis mediated by the innate immune system and T cells. There is an increasing focus on the interaction and relationship of IL-19 with the function of T cells. Contact hypersensitivity (CHS) is T cell-mediated cutaneous inflammation. Therefore, we asked whether IL-19 causes CHS. We investigated the immunological role of IL-19 in CHS induced by 1-fluoro-2, 4-dinitrofluorobenzene as a hapten. IL-19 was highly expressed in skin exposed to the hapten, and ear swelling was increased in IL-19 knockout mice. The exacerbation of the CHS response in IL-19 knockout mice correlated with increased levels of IL-17 and IL-6, but no alterations were noted in the production of interferon (IFN)γ and IL-4 in the T cells of the lymph nodes. In addition to the effect on T cell response, IL-19 knockout mice increased production of inflammatory cytokines. These results show that IL-19 suppressed hapten-dependent skin inflammation in the elicitation phase of CHS.

Original languageEnglish
Pages (from-to)182-189
Number of pages8
JournalBiological and Pharmaceutical Bulletin
Volume41
Issue number2
DOIs
Publication statusPublished - 2018
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science

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