Abstract
Liver injury was induced after infection with Salmonella choleraesuis 31N-1. In T-cell receptor-δ knockout mice, serum alanine transferase level was significantly decreased in comparison with normal control mice after Salmonella infection. On the contrary, in vivo administration of anti-γδ T- cell receptor monoclonal antibody (UC7-13D5) to stimulate γδ-T cells in infected mice significantly increased serum alanine transferase level but decreased bacterial growth compared with infected mice given control antibody (UC8; hamster IgG). These data suggest that γδ-T cells have effector activities not only for protection but also for liver injury during Salmonella infection.
Original language | English |
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Pages (from-to) | 461-469 |
Number of pages | 9 |
Journal | MICROBIOLOGY and IMMUNOLOGY |
Volume | 43 |
Issue number | 5 |
DOIs | |
Publication status | Published - 1999 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Microbiology
- Immunology
- Virology