TY - JOUR
T1 - The role of intrahepatic γδ-T cells for liver injury induced by Salmonella infection in mouse
AU - Ishigami, Masatoshi
AU - Nishimura, Hitoshi
AU - Yoshioka, Kentaro
AU - Kakumu, Shinichi
AU - Yoshikai, Yasunobu
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 1999
Y1 - 1999
N2 - Liver injury was induced after infection with Salmonella choleraesuis 31N-1. In T-cell receptor-δ knockout mice, serum alanine transferase level was significantly decreased in comparison with normal control mice after Salmonella infection. On the contrary, in vivo administration of anti-γδ T- cell receptor monoclonal antibody (UC7-13D5) to stimulate γδ-T cells in infected mice significantly increased serum alanine transferase level but decreased bacterial growth compared with infected mice given control antibody (UC8; hamster IgG). These data suggest that γδ-T cells have effector activities not only for protection but also for liver injury during Salmonella infection.
AB - Liver injury was induced after infection with Salmonella choleraesuis 31N-1. In T-cell receptor-δ knockout mice, serum alanine transferase level was significantly decreased in comparison with normal control mice after Salmonella infection. On the contrary, in vivo administration of anti-γδ T- cell receptor monoclonal antibody (UC7-13D5) to stimulate γδ-T cells in infected mice significantly increased serum alanine transferase level but decreased bacterial growth compared with infected mice given control antibody (UC8; hamster IgG). These data suggest that γδ-T cells have effector activities not only for protection but also for liver injury during Salmonella infection.
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U2 - 10.1111/j.1348-0421.1999.tb02429.x
DO - 10.1111/j.1348-0421.1999.tb02429.x
M3 - Article
C2 - 10449252
AN - SCOPUS:0032588454
VL - 43
SP - 461
EP - 469
JO - Microbiology and Immunology
JF - Microbiology and Immunology
SN - 0385-5600
IS - 5
ER -