The role of intrahepatic γδ-T cells for liver injury induced by Salmonella infection in mouse

Masatoshi Ishigami, Hitoshi Nishimura, Kentaro Yoshioka, Shinichi Kakumu, Yasunobu Yoshikai

    Research output: Contribution to journalArticle

    8 Citations (Scopus)

    Abstract

    Liver injury was induced after infection with Salmonella choleraesuis 31N-1. In T-cell receptor-δ knockout mice, serum alanine transferase level was significantly decreased in comparison with normal control mice after Salmonella infection. On the contrary, in vivo administration of anti-γδ T- cell receptor monoclonal antibody (UC7-13D5) to stimulate γδ-T cells in infected mice significantly increased serum alanine transferase level but decreased bacterial growth compared with infected mice given control antibody (UC8; hamster IgG). These data suggest that γδ-T cells have effector activities not only for protection but also for liver injury during Salmonella infection.

    Original languageEnglish
    Pages (from-to)461-469
    Number of pages9
    JournalMICROBIOLOGY and IMMUNOLOGY
    Volume43
    Issue number5
    DOIs
    Publication statusPublished - Jan 1 1999

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    Salmonella Infections
    Transferases
    T-Cell Antigen Receptor
    T-Lymphocytes
    Alanine
    Liver
    Wounds and Injuries
    Serum
    Knockout Mice
    Cricetinae
    Immunoglobulin G
    Monoclonal Antibodies
    Antibodies
    Growth

    All Science Journal Classification (ASJC) codes

    • Microbiology
    • Immunology
    • Virology

    Cite this

    The role of intrahepatic γδ-T cells for liver injury induced by Salmonella infection in mouse. / Ishigami, Masatoshi; Nishimura, Hitoshi; Yoshioka, Kentaro; Kakumu, Shinichi; Yoshikai, Yasunobu.

    In: MICROBIOLOGY and IMMUNOLOGY, Vol. 43, No. 5, 01.01.1999, p. 461-469.

    Research output: Contribution to journalArticle

    Ishigami, Masatoshi ; Nishimura, Hitoshi ; Yoshioka, Kentaro ; Kakumu, Shinichi ; Yoshikai, Yasunobu. / The role of intrahepatic γδ-T cells for liver injury induced by Salmonella infection in mouse. In: MICROBIOLOGY and IMMUNOLOGY. 1999 ; Vol. 43, No. 5. pp. 461-469.
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