The role of intrahepatic γδ-T cells for liver injury induced by Salmonella infection in mouse

Masatoshi Ishigami, Hitoshi Nishimura, Kentaro Yoshioka, Shinichi Kakumu, Yasunobu Yoshikai

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    Liver injury was induced after infection with Salmonella choleraesuis 31N-1. In T-cell receptor-δ knockout mice, serum alanine transferase level was significantly decreased in comparison with normal control mice after Salmonella infection. On the contrary, in vivo administration of anti-γδ T- cell receptor monoclonal antibody (UC7-13D5) to stimulate γδ-T cells in infected mice significantly increased serum alanine transferase level but decreased bacterial growth compared with infected mice given control antibody (UC8; hamster IgG). These data suggest that γδ-T cells have effector activities not only for protection but also for liver injury during Salmonella infection.

    Original languageEnglish
    Pages (from-to)461-469
    Number of pages9
    Issue number5
    Publication statusPublished - Jan 1 1999


    All Science Journal Classification (ASJC) codes

    • Microbiology
    • Immunology
    • Virology

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