The role of microglia in inflammatory demyelination lesion in the central nervous system

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

In the lesion of experimental autoimmune encephalomyelitis (EAE), two different kinds of macrophages are activated: microglia derived macrophages (MiDM) and monocytes derived macrophages (MDM). These macrophages elicit different functions in the development of demyelination lesions in EAE. MDMs are infiltrated in the acute phase of EAE, and initiate demyelination at the nodes of Ranvier. On the other hands, MiDM always activated at the peak and the chronic stage of the disease. These macrophages express totally different cytokines at different time course of the disease: MDM are activated in the early stage of the disease and express genes that are mainly related to inflammation, while MiDM are activated at the peak and recovery stage and express genes that are related to homeostasis. Our findings provide the idea to develop new therapeutic strategy not only for demyelinating disease but also other neurological diseases with neuro-inflammation.

Original languageEnglish
Pages (from-to)981-983
Number of pages3
JournalClinical Neurology
Volume54
Issue number12
DOIs
Publication statusPublished - Jan 1 2014

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Microglia
Demyelinating Diseases
Central Nervous System
Macrophages
Autoimmune Experimental Encephalomyelitis
Ranvier's Nodes
Inflammation
Genes
Homeostasis
Chronic Disease
Cytokines

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

Cite this

The role of microglia in inflammatory demyelination lesion in the central nervous system. / Yamasaki, Ryo.

In: Clinical Neurology, Vol. 54, No. 12, 01.01.2014, p. 981-983.

Research output: Contribution to journalArticle

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