TY - JOUR
T1 - The Role of Microglial Purinergic Receptors in Pain Signaling
AU - Tozaki-Saitoh, Hidetoshi
AU - Takeda, Hiroshi
AU - Inoue, Kazuhide
N1 - Funding Information:
Funding: This research was funded by Suzuken Memorial foundation, and by the Japan Society for the Promotion of Science (Grant-in-Aid for Transformative Research Areas (A), 20H05900).
Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2022/3/1
Y1 - 2022/3/1
N2 - Pain is an essential modality of sensation in the body. Purinergic signaling plays an important role in nociceptive pain transmission, under both physiological and pathophysiological conditions, and is important for communication between both neuronal and non-neuronal cells. Microglia and astrocytes express a variety of purinergic effectors, and a variety of receptors play critical roles in the pathogenesis of neuropathic pain. In this review, we discuss our current knowledge of purinergic signaling and of the compounds that modulate purinergic transmission, with the aim of highlighting the importance of purinergic pathways as targets for the treatment of persistent pain.
AB - Pain is an essential modality of sensation in the body. Purinergic signaling plays an important role in nociceptive pain transmission, under both physiological and pathophysiological conditions, and is important for communication between both neuronal and non-neuronal cells. Microglia and astrocytes express a variety of purinergic effectors, and a variety of receptors play critical roles in the pathogenesis of neuropathic pain. In this review, we discuss our current knowledge of purinergic signaling and of the compounds that modulate purinergic transmission, with the aim of highlighting the importance of purinergic pathways as targets for the treatment of persistent pain.
UR - http://www.scopus.com/inward/record.url?scp=85126915994&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85126915994&partnerID=8YFLogxK
U2 - 10.3390/molecules27061919
DO - 10.3390/molecules27061919
M3 - Article
C2 - 35335282
AN - SCOPUS:85126915994
VL - 27
JO - Molecules
JF - Molecules
SN - 1420-3049
IS - 6
M1 - 1919
ER -