The role of nuclear Y-box binding protein 1 as a global marker in drug resistance

Michihiko Kuwano, Yoshinao Oda, Hiroto Izumi, Song Ju Yang, Takeshi Uchiumi, Yukihide Iwamoto, Masakazu Toi, Teruhiko Fujii, Hideaki Yamana, Hisafumi Kinoshita, Toshiharu Kamura, Masazumi Tsuneyoshi, Kosei Yasumoto, Kimitoshi Kohno

Research output: Contribution to journalShort survey

102 Citations (Scopus)

Abstract

Gene expression can be regulated by nuclear factors at the transcriptional level. Many such factors regulate MDR1 gene expression, but what are the sequence elements and transcription factors that control the basal and inducible expression of this gene? The general principles through which transcription factors participate in drug resistance are now beginning to be understood. Here, we review the factors involved in the transcriptional regulation of the MDR1 gene. In particular, we focus on the transcription factor Y-box binding protein 1 and discuss the possible links between Y-box binding protein 1 expression and drug resistance in cancer, which are mediated by the transmembrane P-glycoprotein or non - P-glycoprotein.

Original languageEnglish
Pages (from-to)1485-1492
Number of pages8
JournalMolecular Cancer Therapeutics
Volume3
Issue number11
Publication statusPublished - Nov 1 2004

Fingerprint

Y-Box-Binding Protein 1
Drug Resistance
Transcription Factors
P-Glycoprotein
Gene Expression
Genes
Neoplasms

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Kuwano, M., Oda, Y., Izumi, H., Yang, S. J., Uchiumi, T., Iwamoto, Y., ... Kohno, K. (2004). The role of nuclear Y-box binding protein 1 as a global marker in drug resistance. Molecular Cancer Therapeutics, 3(11), 1485-1492.

The role of nuclear Y-box binding protein 1 as a global marker in drug resistance. / Kuwano, Michihiko; Oda, Yoshinao; Izumi, Hiroto; Yang, Song Ju; Uchiumi, Takeshi; Iwamoto, Yukihide; Toi, Masakazu; Fujii, Teruhiko; Yamana, Hideaki; Kinoshita, Hisafumi; Kamura, Toshiharu; Tsuneyoshi, Masazumi; Yasumoto, Kosei; Kohno, Kimitoshi.

In: Molecular Cancer Therapeutics, Vol. 3, No. 11, 01.11.2004, p. 1485-1492.

Research output: Contribution to journalShort survey

Kuwano, M, Oda, Y, Izumi, H, Yang, SJ, Uchiumi, T, Iwamoto, Y, Toi, M, Fujii, T, Yamana, H, Kinoshita, H, Kamura, T, Tsuneyoshi, M, Yasumoto, K & Kohno, K 2004, 'The role of nuclear Y-box binding protein 1 as a global marker in drug resistance', Molecular Cancer Therapeutics, vol. 3, no. 11, pp. 1485-1492.
Kuwano, Michihiko ; Oda, Yoshinao ; Izumi, Hiroto ; Yang, Song Ju ; Uchiumi, Takeshi ; Iwamoto, Yukihide ; Toi, Masakazu ; Fujii, Teruhiko ; Yamana, Hideaki ; Kinoshita, Hisafumi ; Kamura, Toshiharu ; Tsuneyoshi, Masazumi ; Yasumoto, Kosei ; Kohno, Kimitoshi. / The role of nuclear Y-box binding protein 1 as a global marker in drug resistance. In: Molecular Cancer Therapeutics. 2004 ; Vol. 3, No. 11. pp. 1485-1492.
@article{8383f987a8e1453f83337695f2f57bf2,
title = "The role of nuclear Y-box binding protein 1 as a global marker in drug resistance",
abstract = "Gene expression can be regulated by nuclear factors at the transcriptional level. Many such factors regulate MDR1 gene expression, but what are the sequence elements and transcription factors that control the basal and inducible expression of this gene? The general principles through which transcription factors participate in drug resistance are now beginning to be understood. Here, we review the factors involved in the transcriptional regulation of the MDR1 gene. In particular, we focus on the transcription factor Y-box binding protein 1 and discuss the possible links between Y-box binding protein 1 expression and drug resistance in cancer, which are mediated by the transmembrane P-glycoprotein or non - P-glycoprotein.",
author = "Michihiko Kuwano and Yoshinao Oda and Hiroto Izumi and Yang, {Song Ju} and Takeshi Uchiumi and Yukihide Iwamoto and Masakazu Toi and Teruhiko Fujii and Hideaki Yamana and Hisafumi Kinoshita and Toshiharu Kamura and Masazumi Tsuneyoshi and Kosei Yasumoto and Kimitoshi Kohno",
year = "2004",
month = "11",
day = "1",
language = "English",
volume = "3",
pages = "1485--1492",
journal = "Molecular Cancer Therapeutics",
issn = "1535-7163",
publisher = "American Association for Cancer Research Inc.",
number = "11",

}

TY - JOUR

T1 - The role of nuclear Y-box binding protein 1 as a global marker in drug resistance

AU - Kuwano, Michihiko

AU - Oda, Yoshinao

AU - Izumi, Hiroto

AU - Yang, Song Ju

AU - Uchiumi, Takeshi

AU - Iwamoto, Yukihide

AU - Toi, Masakazu

AU - Fujii, Teruhiko

AU - Yamana, Hideaki

AU - Kinoshita, Hisafumi

AU - Kamura, Toshiharu

AU - Tsuneyoshi, Masazumi

AU - Yasumoto, Kosei

AU - Kohno, Kimitoshi

PY - 2004/11/1

Y1 - 2004/11/1

N2 - Gene expression can be regulated by nuclear factors at the transcriptional level. Many such factors regulate MDR1 gene expression, but what are the sequence elements and transcription factors that control the basal and inducible expression of this gene? The general principles through which transcription factors participate in drug resistance are now beginning to be understood. Here, we review the factors involved in the transcriptional regulation of the MDR1 gene. In particular, we focus on the transcription factor Y-box binding protein 1 and discuss the possible links between Y-box binding protein 1 expression and drug resistance in cancer, which are mediated by the transmembrane P-glycoprotein or non - P-glycoprotein.

AB - Gene expression can be regulated by nuclear factors at the transcriptional level. Many such factors regulate MDR1 gene expression, but what are the sequence elements and transcription factors that control the basal and inducible expression of this gene? The general principles through which transcription factors participate in drug resistance are now beginning to be understood. Here, we review the factors involved in the transcriptional regulation of the MDR1 gene. In particular, we focus on the transcription factor Y-box binding protein 1 and discuss the possible links between Y-box binding protein 1 expression and drug resistance in cancer, which are mediated by the transmembrane P-glycoprotein or non - P-glycoprotein.

UR - http://www.scopus.com/inward/record.url?scp=9444259316&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=9444259316&partnerID=8YFLogxK

M3 - Short survey

VL - 3

SP - 1485

EP - 1492

JO - Molecular Cancer Therapeutics

JF - Molecular Cancer Therapeutics

SN - 1535-7163

IS - 11

ER -