The role of pulmonary metastasectomy for hepatoblastoma in children with metastasis at diagnosis: Results from the JPLT-2 study

Tomoro Hishiki, Kenichiro Watanabe, Kohmei Ida, Ken Hoshino, Tomoko Iehara, Yuki Aoki, Takuro Kazama, Kentaro Kihira, Yuichi Takama, Tomoaki Taguchi, Junya Fujimura, Shohei Honda, Kimikazu Matsumoto, Makiko Mori, Michihiro Yano, Akiko Yokoi, Yukichi Tanaka, Hiroshi Fuji, Osamu Miyazaki, Kenichi YoshimuraTetsuya Takimoto, Eiso Hiyama

Research output: Contribution to journalArticle

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Abstract

Background/purpose The purpose of this study was to clarify the role of pulmonary metastasectomy in hepatoblastomas with lung metastasis at diagnosis. We reviewed cases enrolled in the JPLT-2 study. Methods A total of 360 cases with hepatoblastoma were enrolled. The clinical courses and outcome of 60 cases with pulmonary metastasis at diagnosis were reviewed, focusing on metastasectomy. Results Induction chemotherapy resulted in eradication of nodules in 26, residual nodules in 33, and early treatment-related death in one. Of the 33 cases with residual nodules, 11 underwent complete resection of the lung lesions, and among these, progression was reported in five. Complete resection of the liver tumor was not achieved in two of these. Three underwent incomplete resection of lung nodules, eventually leading to progression. Twelve cases with incomplete or no liver tumor resection progressed regardless of the status of lung lesions. Contrarily, among patients who underwent complete resection of the liver tumor, half were cured without metastasectomy. Conclusions Metastasectomy for residual pulmonary nodules after induction chemotherapy is effective provided that the liver tumor could be completely resected. Type of study Prospective Cohort Study. Level of evidence Level II.

Original languageEnglish
Pages (from-to)2051-2055
Number of pages5
JournalJournal of Pediatric Surgery
Volume52
Issue number12
DOIs
Publication statusPublished - Dec 2017

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Metastasectomy
Hepatoblastoma
Neoplasm Metastasis
Lung
Induction Chemotherapy
Liver
Neoplasms
Cohort Studies
Prospective Studies

All Science Journal Classification (ASJC) codes

  • Surgery
  • Pediatrics, Perinatology, and Child Health

Cite this

The role of pulmonary metastasectomy for hepatoblastoma in children with metastasis at diagnosis : Results from the JPLT-2 study. / Hishiki, Tomoro; Watanabe, Kenichiro; Ida, Kohmei; Hoshino, Ken; Iehara, Tomoko; Aoki, Yuki; Kazama, Takuro; Kihira, Kentaro; Takama, Yuichi; Taguchi, Tomoaki; Fujimura, Junya; Honda, Shohei; Matsumoto, Kimikazu; Mori, Makiko; Yano, Michihiro; Yokoi, Akiko; Tanaka, Yukichi; Fuji, Hiroshi; Miyazaki, Osamu; Yoshimura, Kenichi; Takimoto, Tetsuya; Hiyama, Eiso.

In: Journal of Pediatric Surgery, Vol. 52, No. 12, 12.2017, p. 2051-2055.

Research output: Contribution to journalArticle

Hishiki, T, Watanabe, K, Ida, K, Hoshino, K, Iehara, T, Aoki, Y, Kazama, T, Kihira, K, Takama, Y, Taguchi, T, Fujimura, J, Honda, S, Matsumoto, K, Mori, M, Yano, M, Yokoi, A, Tanaka, Y, Fuji, H, Miyazaki, O, Yoshimura, K, Takimoto, T & Hiyama, E 2017, 'The role of pulmonary metastasectomy for hepatoblastoma in children with metastasis at diagnosis: Results from the JPLT-2 study', Journal of Pediatric Surgery, vol. 52, no. 12, pp. 2051-2055. https://doi.org/10.1016/j.jpedsurg.2017.08.031
Hishiki, Tomoro ; Watanabe, Kenichiro ; Ida, Kohmei ; Hoshino, Ken ; Iehara, Tomoko ; Aoki, Yuki ; Kazama, Takuro ; Kihira, Kentaro ; Takama, Yuichi ; Taguchi, Tomoaki ; Fujimura, Junya ; Honda, Shohei ; Matsumoto, Kimikazu ; Mori, Makiko ; Yano, Michihiro ; Yokoi, Akiko ; Tanaka, Yukichi ; Fuji, Hiroshi ; Miyazaki, Osamu ; Yoshimura, Kenichi ; Takimoto, Tetsuya ; Hiyama, Eiso. / The role of pulmonary metastasectomy for hepatoblastoma in children with metastasis at diagnosis : Results from the JPLT-2 study. In: Journal of Pediatric Surgery. 2017 ; Vol. 52, No. 12. pp. 2051-2055.
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abstract = "Background/purpose The purpose of this study was to clarify the role of pulmonary metastasectomy in hepatoblastomas with lung metastasis at diagnosis. We reviewed cases enrolled in the JPLT-2 study. Methods A total of 360 cases with hepatoblastoma were enrolled. The clinical courses and outcome of 60 cases with pulmonary metastasis at diagnosis were reviewed, focusing on metastasectomy. Results Induction chemotherapy resulted in eradication of nodules in 26, residual nodules in 33, and early treatment-related death in one. Of the 33 cases with residual nodules, 11 underwent complete resection of the lung lesions, and among these, progression was reported in five. Complete resection of the liver tumor was not achieved in two of these. Three underwent incomplete resection of lung nodules, eventually leading to progression. Twelve cases with incomplete or no liver tumor resection progressed regardless of the status of lung lesions. Contrarily, among patients who underwent complete resection of the liver tumor, half were cured without metastasectomy. Conclusions Metastasectomy for residual pulmonary nodules after induction chemotherapy is effective provided that the liver tumor could be completely resected. Type of study Prospective Cohort Study. Level of evidence Level II.",
author = "Tomoro Hishiki and Kenichiro Watanabe and Kohmei Ida and Ken Hoshino and Tomoko Iehara and Yuki Aoki and Takuro Kazama and Kentaro Kihira and Yuichi Takama and Tomoaki Taguchi and Junya Fujimura and Shohei Honda and Kimikazu Matsumoto and Makiko Mori and Michihiro Yano and Akiko Yokoi and Yukichi Tanaka and Hiroshi Fuji and Osamu Miyazaki and Kenichi Yoshimura and Tetsuya Takimoto and Eiso Hiyama",
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T1 - The role of pulmonary metastasectomy for hepatoblastoma in children with metastasis at diagnosis

T2 - Results from the JPLT-2 study

AU - Hishiki, Tomoro

AU - Watanabe, Kenichiro

AU - Ida, Kohmei

AU - Hoshino, Ken

AU - Iehara, Tomoko

AU - Aoki, Yuki

AU - Kazama, Takuro

AU - Kihira, Kentaro

AU - Takama, Yuichi

AU - Taguchi, Tomoaki

AU - Fujimura, Junya

AU - Honda, Shohei

AU - Matsumoto, Kimikazu

AU - Mori, Makiko

AU - Yano, Michihiro

AU - Yokoi, Akiko

AU - Tanaka, Yukichi

AU - Fuji, Hiroshi

AU - Miyazaki, Osamu

AU - Yoshimura, Kenichi

AU - Takimoto, Tetsuya

AU - Hiyama, Eiso

PY - 2017/12

Y1 - 2017/12

N2 - Background/purpose The purpose of this study was to clarify the role of pulmonary metastasectomy in hepatoblastomas with lung metastasis at diagnosis. We reviewed cases enrolled in the JPLT-2 study. Methods A total of 360 cases with hepatoblastoma were enrolled. The clinical courses and outcome of 60 cases with pulmonary metastasis at diagnosis were reviewed, focusing on metastasectomy. Results Induction chemotherapy resulted in eradication of nodules in 26, residual nodules in 33, and early treatment-related death in one. Of the 33 cases with residual nodules, 11 underwent complete resection of the lung lesions, and among these, progression was reported in five. Complete resection of the liver tumor was not achieved in two of these. Three underwent incomplete resection of lung nodules, eventually leading to progression. Twelve cases with incomplete or no liver tumor resection progressed regardless of the status of lung lesions. Contrarily, among patients who underwent complete resection of the liver tumor, half were cured without metastasectomy. Conclusions Metastasectomy for residual pulmonary nodules after induction chemotherapy is effective provided that the liver tumor could be completely resected. Type of study Prospective Cohort Study. Level of evidence Level II.

AB - Background/purpose The purpose of this study was to clarify the role of pulmonary metastasectomy in hepatoblastomas with lung metastasis at diagnosis. We reviewed cases enrolled in the JPLT-2 study. Methods A total of 360 cases with hepatoblastoma were enrolled. The clinical courses and outcome of 60 cases with pulmonary metastasis at diagnosis were reviewed, focusing on metastasectomy. Results Induction chemotherapy resulted in eradication of nodules in 26, residual nodules in 33, and early treatment-related death in one. Of the 33 cases with residual nodules, 11 underwent complete resection of the lung lesions, and among these, progression was reported in five. Complete resection of the liver tumor was not achieved in two of these. Three underwent incomplete resection of lung nodules, eventually leading to progression. Twelve cases with incomplete or no liver tumor resection progressed regardless of the status of lung lesions. Contrarily, among patients who underwent complete resection of the liver tumor, half were cured without metastasectomy. Conclusions Metastasectomy for residual pulmonary nodules after induction chemotherapy is effective provided that the liver tumor could be completely resected. Type of study Prospective Cohort Study. Level of evidence Level II.

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