The role of splenectomy before liver transplantation in biliary atresia patients

Yoshiaki Takahashi, Toshiharu Matsuura, Yusuke Yanagi, Koichiro Yoshimaru, Tomoaki Taguchi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background/Purpose There is currently no unified view regarding whether liver transplantation or splenectomy should be performed for hypersplenism before liver transplantation in biliary atresia (BA) patients. We herein describe the efficacy of splenectomy before liver transplantation. Methods Splenectomy was performed in ten patients with hypersplenism associated with BA. We retrospectively reviewed their perioperative and postoperative courses, the number of leukocytes and thrombocytes, and the MELD score. Results The mean age was 17.5 ± 7.0 years (range 11–31 years), and the male-to-female ratio was 1:1. The platelet and leukocyte levels increased after splenectomy and returned to normal levels one month postoperatively. The mean MELD score after splenectomy was significantly decreased after splenectomy: 10 ± 2.1 vs 7.6 ± 1.8. In particular, PT-INR improved. Five patients underwent liver transplantation because of hepatopulmonary syndrome and repeated bouts of cholangitis, whereas the remaining five patients did not undergo liver transplantation because of improvements in the liver function (the mean follow-up period was 56 months). The postoperative complications included portal vein thrombosis and intestinal perforation, but the patient survival rates remained at 100%. Conclusion After splenectomy, both pancytopenia and the liver function clearly improved. Splenectomy should therefore be a treatment option for patients with hypersplenism before liver transplantation. Level of Evidence Retrospective Comparative Study – Level III.

Original languageEnglish
Pages (from-to)2095-2098
Number of pages4
JournalJournal of Pediatric Surgery
Volume51
Issue number12
DOIs
Publication statusPublished - Dec 1 2016

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Biliary Atresia
Splenectomy
Liver Transplantation
Hypersplenism
Blood Platelets
Hepatopulmonary Syndrome
Intestinal Perforation
Pancytopenia
Cholangitis
International Normalized Ratio
Liver
Portal Vein
Leukocyte Count
Thrombosis
Leukocytes
Survival Rate
Retrospective Studies

All Science Journal Classification (ASJC) codes

  • Surgery
  • Pediatrics, Perinatology, and Child Health

Cite this

The role of splenectomy before liver transplantation in biliary atresia patients. / Takahashi, Yoshiaki; Matsuura, Toshiharu; Yanagi, Yusuke; Yoshimaru, Koichiro; Taguchi, Tomoaki.

In: Journal of Pediatric Surgery, Vol. 51, No. 12, 01.12.2016, p. 2095-2098.

Research output: Contribution to journalArticle

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