We investigated the efficacy of surgical resection of metastatic lesions from head and neck squamous cell carcinoma (HNSCC) . We retrospectively reviewed 26 patients who underwent pulmonary or hepatic metastasectomy from HNSCC at Kyushu University Hospital between 2000 and 2016. The primary sites of HNSCC were as follows: nasopharynx in 3 cases, oropharynx in 6 cases, hypopharynx in 8 cases, larynx in 5 cases, tongue in 3 cases, and submandibular gland in 1 case. The metastasectomy was performed for pulmonary metastases in 22 cases and hepatic metastases in 4 cases. The overall 1-and 2-year survival rates were 78％ and 70.9％, respectively. The short disease-free interval from initial treatment to distant metastasis was associated with shorter overall survival after metastasectomy. Continued and careful surveillance is important after surgical resection of metastatic lesions.
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