The role of the immune system in early epithelial carcinogenesis: B-ware the double-edged sword

Alan N. Houghton; Hiroshi Uchi; Jedd D. Wolchok

doi:10.1016/j.ccr.2005.04.026

The role of the immune system in early epithelial carcinogenesis: B-ware the double-edged sword

Alan N. Houghton, Hiroshi Uchi, Jedd D. Wolchok

Research output: Contribution to journal › Short survey › peer-review

16 Citations (Scopus)

Abstract

Cancer is commonly described as a disease of genetic mutations. However, epidemiologic and clinical evidence points to the important but multifaceted role of the host. The immune system has something to say about cancer evolution through promotion of malignancy by inflammatory myeloid cells of the innate immune system. In a report in this issue of Cancer Cell, B cells are implicated as key players in the regulation of chronic inflammation that promotes early events in epithelial carcinogenesis. These are surprising observations, linking antibodies of the adaptive immune system to innate immune responses that drive epithelial carcinogenesis.

Original language	English
Pages (from-to)	403-405
Number of pages	3
Journal	Cancer Cell
Volume	7
Issue number	5
DOIs	https://doi.org/10.1016/j.ccr.2005.04.026
Publication status	Published - May 2005
Externally published	Yes

All Science Journal Classification (ASJC) codes

Oncology
Cell Biology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ccr.2005.04.026

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abstract = "Cancer is commonly described as a disease of genetic mutations. However, epidemiologic and clinical evidence points to the important but multifaceted role of the host. The immune system has something to say about cancer evolution through promotion of malignancy by inflammatory myeloid cells of the innate immune system. In a report in this issue of Cancer Cell, B cells are implicated as key players in the regulation of chronic inflammation that promotes early events in epithelial carcinogenesis. These are surprising observations, linking antibodies of the adaptive immune system to innate immune responses that drive epithelial carcinogenesis.",

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T2 - B-ware the double-edged sword

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AU - Uchi, Hiroshi

AU - Wolchok, Jedd D.

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AB - Cancer is commonly described as a disease of genetic mutations. However, epidemiologic and clinical evidence points to the important but multifaceted role of the host. The immune system has something to say about cancer evolution through promotion of malignancy by inflammatory myeloid cells of the innate immune system. In a report in this issue of Cancer Cell, B cells are implicated as key players in the regulation of chronic inflammation that promotes early events in epithelial carcinogenesis. These are surprising observations, linking antibodies of the adaptive immune system to innate immune responses that drive epithelial carcinogenesis.

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JO - Cancer Cell

JF - Cancer Cell

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ER -

The role of the immune system in early epithelial carcinogenesis: B-ware the double-edged sword

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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