The role of the spleen, platelets, and plasma hepatocyte growth factor activity on hepatic regeneration in rats

Morimasa Tomikawa, Makoto Hashizume, Hidefumi Higashi, Masayuki Ohta, Keizo Sugimachi

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Abstract

BACKGROUND: Hepatocyte growth factor (HGF) is a humoral factor that may act as a trigger for hepatic regeneration. In this study, changes in the plasma HGF activity on hepatic regeneration in a splenectomized condition were measured for the first time, while the role of the spleen and platelets on hepatic regeneration were also carefully evaluated. STUDY DESIGN: Seventy- five male Wister rats were classified into three groups: group A consisted of rats who underwent a sham operation and a partial hepatectomy; group B consisted of those who underwent a splenectomy and partial hepatectomy; and group C consisted of those who underwent a splenectomy, partial hepatectomy, and were administered an antiplatelet agent. RESULTS: At 24 hours after partial hepatectomy, the weights of the livers of the rats in groups B and C were significantly greater than those of group A, while the labeling index of group C was significantly higher than that of group A and also tended to be higher than that of group B. Regarding the number of platelets, the transient increase in group A occurred earlier than that of either group B or C. The plasma HGF activities also showed a transient increase and the maximum levels were reached at 24 hours in group A, six hours in group B, and 12 hours in group C. CONCLUSIONS: It is suggested that the spleen plays an inhibitory role in hepatic regeneration. In the early stage of hepatic regeneration, platelets possibly control HGF induction, while in the following stage, a possible feedback mechanism is also postulated to exist.

Original languageEnglish
Pages (from-to)12-16
Number of pages5
JournalJournal of the American College of Surgeons
Volume182
Issue number1
Publication statusPublished - Jan 1 1996

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Hepatocyte Growth Factor
Regeneration
Blood Platelets
Spleen
Hepatectomy
Liver
Splenectomy
Platelet Aggregation Inhibitors
Platelet Count
Weights and Measures

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

The role of the spleen, platelets, and plasma hepatocyte growth factor activity on hepatic regeneration in rats. / Tomikawa, Morimasa; Hashizume, Makoto; Higashi, Hidefumi; Ohta, Masayuki; Sugimachi, Keizo.

In: Journal of the American College of Surgeons, Vol. 182, No. 1, 01.01.1996, p. 12-16.

Research output: Contribution to journalArticle

Tomikawa, Morimasa ; Hashizume, Makoto ; Higashi, Hidefumi ; Ohta, Masayuki ; Sugimachi, Keizo. / The role of the spleen, platelets, and plasma hepatocyte growth factor activity on hepatic regeneration in rats. In: Journal of the American College of Surgeons. 1996 ; Vol. 182, No. 1. pp. 12-16.
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