The role of Tsukushi as an extracellular signaling coordinator

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Citations (Scopus)

Abstract

Temporal and spatial coordination of multiple signaling pathways is essential for finely tuned cellular regulation in development. Extracellular signaling molecules that function in a concentration-dependent manner, collectively called morphogens, and their inhibitors both play pivotal roles in the regulation of embryogenesis. Understanding concerning the coordination of these signal molecule-dependent pathways has been mainly about the mechanisms of intracellular crosstalk. Small leucine-rich proteoglycan (SLRP) family proteins modulate various cellular processes, that is, cellular proliferation, growth, differentiation, survival, and adhesion. In this chapter, I discuss signal coordination at the extracellular level by this family of proteins that interact with a variety of signaling molecules, as exemplified by Tsukushi (TSK). We discovered a novel SLRP family member, TSK, which is expressed and secreted in several specific tissue areas where embryonic organogenesis is ongoing. TSK binds nodal/Vg1/TGF-β1, BMP4/chordin, FGF8, Frizzled4, and Delta and modulates their downstream intracellular signaling pathways, indicating multiple regulatory functions of TSK during development.

Original languageEnglish
Title of host publicationNew Principles in Developmental Processes
PublisherSpringer Japan
Pages227-238
Number of pages12
ISBN (Electronic)9784431546344
ISBN (Print)4431546332, 9784431546337
DOIs
Publication statusPublished - Nov 1 2013
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'The role of Tsukushi as an extracellular signaling coordinator'. Together they form a unique fingerprint.

  • Cite this

    Ohta, K. (2013). The role of Tsukushi as an extracellular signaling coordinator. In New Principles in Developmental Processes (pp. 227-238). Springer Japan. https://doi.org/10.1007/978-4-431-54634-4_17