Temporal and spatial coordination of multiple signaling pathways is essential for finely tuned cellular regulation in development. Extracellular signaling molecules that function in a concentration-dependent manner, collectively called morphogens, and their inhibitors both play pivotal roles in the regulation of embryogenesis. Understanding concerning the coordination of these signal molecule-dependent pathways has been mainly about the mechanisms of intracellular crosstalk. Small leucine-rich proteoglycan (SLRP) family proteins modulate various cellular processes, that is, cellular proliferation, growth, differentiation, survival, and adhesion. In this chapter, I discuss signal coordination at the extracellular level by this family of proteins that interact with a variety of signaling molecules, as exemplified by Tsukushi (TSK). We discovered a novel SLRP family member, TSK, which is expressed and secreted in several specific tissue areas where embryonic organogenesis is ongoing. TSK binds nodal/Vg1/TGF-β1, BMP4/chordin, FGF8, Frizzled4, and Delta and modulates their downstream intracellular signaling pathways, indicating multiple regulatory functions of TSK during development.
|Title of host publication||New Principles in Developmental Processes|
|Number of pages||12|
|ISBN (Print)||4431546332, 9784431546337|
|Publication status||Published - Nov 1 2013|
All Science Journal Classification (ASJC) codes
- Biochemistry, Genetics and Molecular Biology(all)