The roles of angiotensin II in stretched periodontal ligament cells

S. Monnouchi, H. Maeda, S. Fujii, A. Tomokiyo, K. Kono, A. Akamine

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)


The loading caused by occlusion and mastication plays an important role in maintaining periodontal ligament (PDL) tissues. We hypothesized that a loading magnitude would be involved in the production of biological factors that function in the maintenance of PDL tissues. Here, we identified up-regulated gene expressions of transforming growth factor-Î1 (TGF-Î1), alkaline phosphatase (ALP), and angiotensinogen in human PDL fibroblastic cells (HPLFs) that were exposed to 8% stretch loading. Immunolocalization of angiotensin I/II (Ang I/II), which was converted from angiotensinogen, was detected in rat PDL tissues. HPLFs that were stimulated by Ang II also increased their gene expressions of TGF-Î1 and ALP. Furthermore, the antagonist for Ang II type 2 receptor, rather than for type 1, significantly inhibited gene expressions induced by the stretch loading. Analysis of these data suggests that Ang II mediates the loading signal in stretched HPLFs to induce expressions of TGF-Î1 and ALP.

Original languageEnglish
Pages (from-to)181-185
Number of pages5
JournalJournal of Dental Research
Issue number2
Publication statusPublished - Feb 2011

All Science Journal Classification (ASJC) codes

  • Dentistry(all)


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