The self-assembled monolayer of saccharide via click chemistry: Formation and protein recognition

Yoshiko Miura; Takahiro Yamauchi; Hajime Sato; Tomohiro Fukuda

doi:10.1016/j.tsf.2007.04.061

The self-assembled monolayer of saccharide via click chemistry: Formation and protein recognition

Yoshiko Miura, Takahiro Yamauchi, Hajime Sato, Tomohiro Fukuda

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

We prepared the saccharide-immobilized substrate via click chemistry. The azide-terminated saccharides were reacted by a facile metathesis reaction. The density of saccharides was controlled by the incubation time of SAM preparation. The saccharide-protein interaction was analyzed using the saccharide substrate. The interaction of the saccharide substrate with protein was strong and specific due to the glyco-cluster effects. The interaction with amyloid β was analyzed by the monosaccharide-immobilized substrate, and the sulfonated saccharides showed strong interaction.

Original language	English
Pages (from-to)	2443-2449
Number of pages	7
Journal	Thin Solid Films
Volume	516
Issue number	9
DOIs	https://doi.org/10.1016/j.tsf.2007.04.061
Publication status	Published - Mar 3 2008
Externally published	Yes

All Science Journal Classification (ASJC) codes

Electronic, Optical and Magnetic Materials
Surfaces and Interfaces
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1016/j.tsf.2007.04.061

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title = "The self-assembled monolayer of saccharide via click chemistry: Formation and protein recognition",

abstract = "We prepared the saccharide-immobilized substrate via click chemistry. The azide-terminated saccharides were reacted by a facile metathesis reaction. The density of saccharides was controlled by the incubation time of SAM preparation. The saccharide-protein interaction was analyzed using the saccharide substrate. The interaction of the saccharide substrate with protein was strong and specific due to the glyco-cluster effects. The interaction with amyloid β was analyzed by the monosaccharide-immobilized substrate, and the sulfonated saccharides showed strong interaction.",

author = "Yoshiko Miura and Takahiro Yamauchi and Hajime Sato and Tomohiro Fukuda",

note = "Funding Information: This work was supported by the Industrial Technology Research Grant Program in '03 from New Energy and Industrial Technology Development Organization (NEDO) of Japan, Mitani Foundation and Shinsedai Foundation. The authors are grateful to Prof. Yoshihiro Nishida for saccharide syntheses. ",

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doi = "10.1016/j.tsf.2007.04.061",

language = "English",

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T1 - The self-assembled monolayer of saccharide via click chemistry

T2 - Formation and protein recognition

AU - Miura, Yoshiko

AU - Yamauchi, Takahiro

AU - Sato, Hajime

AU - Fukuda, Tomohiro

N1 - Funding Information: This work was supported by the Industrial Technology Research Grant Program in '03 from New Energy and Industrial Technology Development Organization (NEDO) of Japan, Mitani Foundation and Shinsedai Foundation. The authors are grateful to Prof. Yoshihiro Nishida for saccharide syntheses.

PY - 2008/3/3

Y1 - 2008/3/3

N2 - We prepared the saccharide-immobilized substrate via click chemistry. The azide-terminated saccharides were reacted by a facile metathesis reaction. The density of saccharides was controlled by the incubation time of SAM preparation. The saccharide-protein interaction was analyzed using the saccharide substrate. The interaction of the saccharide substrate with protein was strong and specific due to the glyco-cluster effects. The interaction with amyloid β was analyzed by the monosaccharide-immobilized substrate, and the sulfonated saccharides showed strong interaction.

AB - We prepared the saccharide-immobilized substrate via click chemistry. The azide-terminated saccharides were reacted by a facile metathesis reaction. The density of saccharides was controlled by the incubation time of SAM preparation. The saccharide-protein interaction was analyzed using the saccharide substrate. The interaction of the saccharide substrate with protein was strong and specific due to the glyco-cluster effects. The interaction with amyloid β was analyzed by the monosaccharide-immobilized substrate, and the sulfonated saccharides showed strong interaction.

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M3 - Article

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JO - Thin Solid Films

JF - Thin Solid Films

SN - 0040-6090

IS - 9

ER -

The self-assembled monolayer of saccharide via click chemistry: Formation and protein recognition

Abstract

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