The self-assembled monolayer of saccharide via click chemistry: Formation and protein recognition

Yoshiko Miura; Takahiro Yamauchi; Hajime Sato; Tomohiro Fukuda

doi:10.1016/j.tsf.2007.04.061

The self-assembled monolayer of saccharide via click chemistry: Formation and protein recognition

Yoshiko Miura, Takahiro Yamauchi, Hajime Sato, Tomohiro Fukuda

Chemical Engineering

Research output: Contribution to journal › Article

26 Citations (Scopus)

Abstract

We prepared the saccharide-immobilized substrate via click chemistry. The azide-terminated saccharides were reacted by a facile metathesis reaction. The density of saccharides was controlled by the incubation time of SAM preparation. The saccharide-protein interaction was analyzed using the saccharide substrate. The interaction of the saccharide substrate with protein was strong and specific due to the glyco-cluster effects. The interaction with amyloid β was analyzed by the monosaccharide-immobilized substrate, and the sulfonated saccharides showed strong interaction.

Original language	English
Pages (from-to)	2443-2449
Number of pages	7
Journal	Thin Solid Films
Volume	516
Issue number	9
DOIs	https://doi.org/10.1016/j.tsf.2007.04.061
Publication status	Published - Mar 3 2008

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All Science Journal Classification (ASJC) codes

Electronic, Optical and Magnetic Materials
Surfaces and Interfaces
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

Cite this

Miura, Y., Yamauchi, T., Sato, H., & Fukuda, T. (2008). The self-assembled monolayer of saccharide via click chemistry: Formation and protein recognition. Thin Solid Films, 516(9), 2443-2449. https://doi.org/10.1016/j.tsf.2007.04.061

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10.1016/j.tsf.2007.04.061