The self-assembled monolayer of saccharide via click chemistry: Formation and protein recognition

Yoshiko Miura; Takahiro Yamauchi; Hajime Sato; Tomohiro Fukuda

doi:10.1016/j.tsf.2007.04.061

The self-assembled monolayer of saccharide via click chemistry: Formation and protein recognition

Yoshiko Miura, Takahiro Yamauchi, Hajime Sato, Tomohiro Fukuda

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

We prepared the saccharide-immobilized substrate via click chemistry. The azide-terminated saccharides were reacted by a facile metathesis reaction. The density of saccharides was controlled by the incubation time of SAM preparation. The saccharide-protein interaction was analyzed using the saccharide substrate. The interaction of the saccharide substrate with protein was strong and specific due to the glyco-cluster effects. The interaction with amyloid β was analyzed by the monosaccharide-immobilized substrate, and the sulfonated saccharides showed strong interaction.

Original language	English
Pages (from-to)	2443-2449
Number of pages	7
Journal	Thin Solid Films
Volume	516
Issue number	9
DOIs	https://doi.org/10.1016/j.tsf.2007.04.061
Publication status	Published - Mar 3 2008
Externally published	Yes

All Science Journal Classification (ASJC) codes

Electronic, Optical and Magnetic Materials
Surfaces and Interfaces
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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abstract = "We prepared the saccharide-immobilized substrate via click chemistry. The azide-terminated saccharides were reacted by a facile metathesis reaction. The density of saccharides was controlled by the incubation time of SAM preparation. The saccharide-protein interaction was analyzed using the saccharide substrate. The interaction of the saccharide substrate with protein was strong and specific due to the glyco-cluster effects. The interaction with amyloid β was analyzed by the monosaccharide-immobilized substrate, and the sulfonated saccharides showed strong interaction.",

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T1 - The self-assembled monolayer of saccharide via click chemistry

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AU - Miura, Yoshiko

AU - Yamauchi, Takahiro

AU - Sato, Hajime

AU - Fukuda, Tomohiro

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AB - We prepared the saccharide-immobilized substrate via click chemistry. The azide-terminated saccharides were reacted by a facile metathesis reaction. The density of saccharides was controlled by the incubation time of SAM preparation. The saccharide-protein interaction was analyzed using the saccharide substrate. The interaction of the saccharide substrate with protein was strong and specific due to the glyco-cluster effects. The interaction with amyloid β was analyzed by the monosaccharide-immobilized substrate, and the sulfonated saccharides showed strong interaction.

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