The self-assembled monolayer of saccharide via click chemistry: Formation and protein recognition

Yoshiko Miura, Takahiro Yamauchi, Hajime Sato, Tomohiro Fukuda

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26 Citations (Scopus)

Abstract

We prepared the saccharide-immobilized substrate via click chemistry. The azide-terminated saccharides were reacted by a facile metathesis reaction. The density of saccharides was controlled by the incubation time of SAM preparation. The saccharide-protein interaction was analyzed using the saccharide substrate. The interaction of the saccharide substrate with protein was strong and specific due to the glyco-cluster effects. The interaction with amyloid β was analyzed by the monosaccharide-immobilized substrate, and the sulfonated saccharides showed strong interaction.

Original languageEnglish
Pages (from-to)2443-2449
Number of pages7
JournalThin Solid Films
Volume516
Issue number9
DOIs
Publication statusPublished - Mar 3 2008

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All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Surfaces and Interfaces
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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