The severity of obstructive sleep apnea syndrome cannot predict the accumulation of brain amyloid by imaging with [11C]-Pittsburgh compound B PET computed tomography in patients with a normal cognitive function

Sakiko Shimizu Handa, Shingo Baba, Kenichiro Yamashita, Mari Nishizaka, Shinichi Ando

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objective: Disturbed sleep due to obstructive sleep apnea syndrome (OSAS) might accelerate amyloidβ (Aβ) deposition, which can be a crucial factor in Alzheimer’s disease. We studied Aβ deposition in untreated OSAS patients with normal cognition. Method: We performed polysomnography (PSG) and Aβ imaging with [11C]-Pittsburgh compound B PET computed tomography (11C-PiB PET CT) in 14 untreated OSAS patients (apnea–hypopnea index: 43.8 ± 26.3/h). Results: The abnormal accumulation of enhanced 11C-PiB PET was observed only one patient with severe, but not the most severe. Conclusions: The OSAS severity alone may not predict Aβ deposition in OSAS patients with normal cognition.

Original languageEnglish
Pages (from-to)541-544
Number of pages4
JournalAnnals of Nuclear Medicine
Volume33
Issue number7
DOIs
Publication statusPublished - Jul 1 2019

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

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