The significance of methicillin-resistant Staphylococcus Aureus infection in general surgery

A multivariate analysis of risk factors and preventive approaches

Mitsuo Shimada, Tatsuro Kamakura, Hidetoshi Itasaka, Takashi Matsumata, Makoto Hashizume, Keizo Sugimachi

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

To investigate the characteristics, risk factors, and prevention of methicillin-resistant Staphylococcus aureus (MRSA), a total of 3,627 patients were studied. Among these, 1,336 patients with various infections were used in a risk factor analysis of MRSA to determine the relationship between the use of antibiotics and the incidence of MRSA. Only 3.0% of infections were attributed to MRSA, the esophagus and colorectal region being highly involved, as anastomotic or pelvic abscesses, while the lung had a lower incidence. Almost half the patients with MRSA infections (47.6%) had concomitant infections. A univariate analysis revealed the following significant factors: The coexistence of gastrointestinal or metastatic malignancy, sepsis, tracheostomy, and the prior use of antibiotics such as the β-lactam compounds or aminoglycosides. A multivariate analysis showed that gastrointestinal malignancy, sepsis, and the prior use of aminoglycosides, tetracycline, macrolides, and carbapenems were independently significant factors. To promote the education of doctors and nurses, regular in-service meetings on MRSA were held in the ward. Moreover, preventive approaches such as patient isolation, strategically placed hand washing equipment, and the use of disposable gloves and contaminated waste bags, have been initiated, and the incidence of MRSA has decreased significantly since then. Thus, to control MRSA, the following steps should be taken: (1) constant and careful surveillance, (2) regular risk factor analyses, (3) the optimal administration of antibiotics, and (4) the education of all hospital staff.

Original languageEnglish
Pages (from-to)880-884
Number of pages5
JournalSurgery Today
Volume23
Issue number10
DOIs
Publication statusPublished - Oct 1 1993

Fingerprint

Methicillin-Resistant Staphylococcus aureus
Multivariate Analysis
Infection
Aminoglycosides
Anti-Bacterial Agents
Statistical Factor Analysis
Disposable Equipment
Sepsis
Incidence
Patient Isolation
Lung Abscess
Education
Lactams
Hand Disinfection
Carbapenems
Tracheostomy
Macrolides
Tetracycline
Esophagus
Neoplasms

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

The significance of methicillin-resistant Staphylococcus Aureus infection in general surgery : A multivariate analysis of risk factors and preventive approaches. / Shimada, Mitsuo; Kamakura, Tatsuro; Itasaka, Hidetoshi; Matsumata, Takashi; Hashizume, Makoto; Sugimachi, Keizo.

In: Surgery Today, Vol. 23, No. 10, 01.10.1993, p. 880-884.

Research output: Contribution to journalArticle

Shimada, Mitsuo ; Kamakura, Tatsuro ; Itasaka, Hidetoshi ; Matsumata, Takashi ; Hashizume, Makoto ; Sugimachi, Keizo. / The significance of methicillin-resistant Staphylococcus Aureus infection in general surgery : A multivariate analysis of risk factors and preventive approaches. In: Surgery Today. 1993 ; Vol. 23, No. 10. pp. 880-884.
@article{1bacba1ec65447a2b7b043bdd7c22aed,
title = "The significance of methicillin-resistant Staphylococcus Aureus infection in general surgery: A multivariate analysis of risk factors and preventive approaches",
abstract = "To investigate the characteristics, risk factors, and prevention of methicillin-resistant Staphylococcus aureus (MRSA), a total of 3,627 patients were studied. Among these, 1,336 patients with various infections were used in a risk factor analysis of MRSA to determine the relationship between the use of antibiotics and the incidence of MRSA. Only 3.0{\%} of infections were attributed to MRSA, the esophagus and colorectal region being highly involved, as anastomotic or pelvic abscesses, while the lung had a lower incidence. Almost half the patients with MRSA infections (47.6{\%}) had concomitant infections. A univariate analysis revealed the following significant factors: The coexistence of gastrointestinal or metastatic malignancy, sepsis, tracheostomy, and the prior use of antibiotics such as the β-lactam compounds or aminoglycosides. A multivariate analysis showed that gastrointestinal malignancy, sepsis, and the prior use of aminoglycosides, tetracycline, macrolides, and carbapenems were independently significant factors. To promote the education of doctors and nurses, regular in-service meetings on MRSA were held in the ward. Moreover, preventive approaches such as patient isolation, strategically placed hand washing equipment, and the use of disposable gloves and contaminated waste bags, have been initiated, and the incidence of MRSA has decreased significantly since then. Thus, to control MRSA, the following steps should be taken: (1) constant and careful surveillance, (2) regular risk factor analyses, (3) the optimal administration of antibiotics, and (4) the education of all hospital staff.",
author = "Mitsuo Shimada and Tatsuro Kamakura and Hidetoshi Itasaka and Takashi Matsumata and Makoto Hashizume and Keizo Sugimachi",
year = "1993",
month = "10",
day = "1",
doi = "10.1007/BF00311366",
language = "English",
volume = "23",
pages = "880--884",
journal = "Surgery Today",
issn = "0941-1291",
publisher = "Springer Japan",
number = "10",

}

TY - JOUR

T1 - The significance of methicillin-resistant Staphylococcus Aureus infection in general surgery

T2 - A multivariate analysis of risk factors and preventive approaches

AU - Shimada, Mitsuo

AU - Kamakura, Tatsuro

AU - Itasaka, Hidetoshi

AU - Matsumata, Takashi

AU - Hashizume, Makoto

AU - Sugimachi, Keizo

PY - 1993/10/1

Y1 - 1993/10/1

N2 - To investigate the characteristics, risk factors, and prevention of methicillin-resistant Staphylococcus aureus (MRSA), a total of 3,627 patients were studied. Among these, 1,336 patients with various infections were used in a risk factor analysis of MRSA to determine the relationship between the use of antibiotics and the incidence of MRSA. Only 3.0% of infections were attributed to MRSA, the esophagus and colorectal region being highly involved, as anastomotic or pelvic abscesses, while the lung had a lower incidence. Almost half the patients with MRSA infections (47.6%) had concomitant infections. A univariate analysis revealed the following significant factors: The coexistence of gastrointestinal or metastatic malignancy, sepsis, tracheostomy, and the prior use of antibiotics such as the β-lactam compounds or aminoglycosides. A multivariate analysis showed that gastrointestinal malignancy, sepsis, and the prior use of aminoglycosides, tetracycline, macrolides, and carbapenems were independently significant factors. To promote the education of doctors and nurses, regular in-service meetings on MRSA were held in the ward. Moreover, preventive approaches such as patient isolation, strategically placed hand washing equipment, and the use of disposable gloves and contaminated waste bags, have been initiated, and the incidence of MRSA has decreased significantly since then. Thus, to control MRSA, the following steps should be taken: (1) constant and careful surveillance, (2) regular risk factor analyses, (3) the optimal administration of antibiotics, and (4) the education of all hospital staff.

AB - To investigate the characteristics, risk factors, and prevention of methicillin-resistant Staphylococcus aureus (MRSA), a total of 3,627 patients were studied. Among these, 1,336 patients with various infections were used in a risk factor analysis of MRSA to determine the relationship between the use of antibiotics and the incidence of MRSA. Only 3.0% of infections were attributed to MRSA, the esophagus and colorectal region being highly involved, as anastomotic or pelvic abscesses, while the lung had a lower incidence. Almost half the patients with MRSA infections (47.6%) had concomitant infections. A univariate analysis revealed the following significant factors: The coexistence of gastrointestinal or metastatic malignancy, sepsis, tracheostomy, and the prior use of antibiotics such as the β-lactam compounds or aminoglycosides. A multivariate analysis showed that gastrointestinal malignancy, sepsis, and the prior use of aminoglycosides, tetracycline, macrolides, and carbapenems were independently significant factors. To promote the education of doctors and nurses, regular in-service meetings on MRSA were held in the ward. Moreover, preventive approaches such as patient isolation, strategically placed hand washing equipment, and the use of disposable gloves and contaminated waste bags, have been initiated, and the incidence of MRSA has decreased significantly since then. Thus, to control MRSA, the following steps should be taken: (1) constant and careful surveillance, (2) regular risk factor analyses, (3) the optimal administration of antibiotics, and (4) the education of all hospital staff.

UR - http://www.scopus.com/inward/record.url?scp=0027361232&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027361232&partnerID=8YFLogxK

U2 - 10.1007/BF00311366

DO - 10.1007/BF00311366

M3 - Article

VL - 23

SP - 880

EP - 884

JO - Surgery Today

JF - Surgery Today

SN - 0941-1291

IS - 10

ER -