The solubility and stability of amino acids in biocompatible ionic liquids

T. Vasantha; Awanish Kumar; Pankaj Attri; Pannuru Venkatesu; R. S. Rama Devi

doi:10.2174/09298665113209990071

The solubility and stability of amino acids in biocompatible ionic liquids

T. Vasantha, Awanish Kumar, Pankaj Attri, Pannuru Venkatesu, R. S. Rama Devi

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

In recent years, ionic liquids (ILs) represent a new class of biocompatible co-solvents for biomolecules. In this work, we report the apparent transfer free energies (ΔG′_tr) for six amino acids (AA) from water to aqueous solutions of six ammonium based ILs (diethylammonium acetate (DEAA), diethylammonium sulfate (DEAS), triethyl ammonium acetate (TEAA), triethylammonium sulfate (TEAS), triethylammonium dihydrogen phosphate (TEAP), and trimethylammonium acetate (TMAA)) through solubility measurements, as a function of IL concentration at 298.15 K under atmospheric pressure. Salting-out effect was found for AA in aqueous IL solutions with increasing IL concentrations. In addition, we observed positive values of ΔG′ _tr for AA from water to ILs, indicating that the interactions between ILs and AA are unfavorable. From the obtained results, we found that the selected ammonium based ILs act as stabilizers for the structure of AA.

Original language	English
Pages (from-to)	15-24
Number of pages	10
Journal	Protein and Peptide Letters
Volume	21
Issue number	1
DOIs	https://doi.org/10.2174/09298665113209990071
Publication status	Published - Jan 1 2014
Externally published	Yes

All Science Journal Classification (ASJC) codes

Structural Biology
Biochemistry

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abstract = "In recent years, ionic liquids (ILs) represent a new class of biocompatible co-solvents for biomolecules. In this work, we report the apparent transfer free energies (ΔG′tr) for six amino acids (AA) from water to aqueous solutions of six ammonium based ILs (diethylammonium acetate (DEAA), diethylammonium sulfate (DEAS), triethyl ammonium acetate (TEAA), triethylammonium sulfate (TEAS), triethylammonium dihydrogen phosphate (TEAP), and trimethylammonium acetate (TMAA)) through solubility measurements, as a function of IL concentration at 298.15 K under atmospheric pressure. Salting-out effect was found for AA in aqueous IL solutions with increasing IL concentrations. In addition, we observed positive values of ΔG′ tr for AA from water to ILs, indicating that the interactions between ILs and AA are unfavorable. From the obtained results, we found that the selected ammonium based ILs act as stabilizers for the structure of AA.",

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AU - Kumar, Awanish

AU - Attri, Pankaj

AU - Venkatesu, Pannuru

AU - Rama Devi, R. S.

PY - 2014/1/1

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N2 - In recent years, ionic liquids (ILs) represent a new class of biocompatible co-solvents for biomolecules. In this work, we report the apparent transfer free energies (ΔG′tr) for six amino acids (AA) from water to aqueous solutions of six ammonium based ILs (diethylammonium acetate (DEAA), diethylammonium sulfate (DEAS), triethyl ammonium acetate (TEAA), triethylammonium sulfate (TEAS), triethylammonium dihydrogen phosphate (TEAP), and trimethylammonium acetate (TMAA)) through solubility measurements, as a function of IL concentration at 298.15 K under atmospheric pressure. Salting-out effect was found for AA in aqueous IL solutions with increasing IL concentrations. In addition, we observed positive values of ΔG′ tr for AA from water to ILs, indicating that the interactions between ILs and AA are unfavorable. From the obtained results, we found that the selected ammonium based ILs act as stabilizers for the structure of AA.

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