The SQUU-B cell line spreads its metastatic properties to nonmetastatic clone SQUU-A from the same patient through exosomes

Tomoyo Kawakubo-Yasukochi; Masahiko Morioka; Yoshikazu Hayashi; Takuya Nishinakagawa; Mai Hazekawa; Shintaro Kawano; Seiji Nakamura; Manabu Nakashima

doi:10.1016/j.job.2015.10.001

The SQUU-B cell line spreads its metastatic properties to nonmetastatic clone SQUU-A from the same patient through exosomes

Tomoyo Kawakubo-Yasukochi, Masahiko Morioka, Yoshikazu Hayashi, Takuya Nishinakagawa, Mai Hazekawa, Shintaro Kawano, Seiji Nakamura, Manabu Nakashima

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Emerging evidence indicates that cancer-derived exosomes increase the tumorigenic potential of tumor cells by reprogramming the cells associated with the tumor microenvironment. Our aim was to examine the cross talk via exosomes between two oral squamous cell carcinoma (OSCC) clones from the same patient. Our data showed that exosomes derived from highly metastatic SQUU-B cells conferred metastatic ability to nonmetastatic SQUU-A cells and subsequently reduced mRNA expression of cytokeratin 13, which is strongly linked to malignant transformation of OSCCs. The results suggest that multiple cell clones secrete their unique exosomes within the malignant tumor mass, which mediate paracrine interactions with other cell clones and affect clinical prognosis.

Original language	English
Pages (from-to)	33-38
Number of pages	6
Journal	journal of oral biosciences
Volume	58
Issue number	1
DOIs	https://doi.org/10.1016/j.job.2015.10.001
Publication status	Published - Feb 1 2016

All Science Journal Classification (ASJC) codes

Medicine (miscellaneous)
Biochemistry, Genetics and Molecular Biology(all)
Dentistry(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.job.2015.10.001

Cite this

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title = "The SQUU-B cell line spreads its metastatic properties to nonmetastatic clone SQUU-A from the same patient through exosomes",

abstract = "Emerging evidence indicates that cancer-derived exosomes increase the tumorigenic potential of tumor cells by reprogramming the cells associated with the tumor microenvironment. Our aim was to examine the cross talk via exosomes between two oral squamous cell carcinoma (OSCC) clones from the same patient. Our data showed that exosomes derived from highly metastatic SQUU-B cells conferred metastatic ability to nonmetastatic SQUU-A cells and subsequently reduced mRNA expression of cytokeratin 13, which is strongly linked to malignant transformation of OSCCs. The results suggest that multiple cell clones secrete their unique exosomes within the malignant tumor mass, which mediate paracrine interactions with other cell clones and affect clinical prognosis.",

author = "Tomoyo Kawakubo-Yasukochi and Masahiko Morioka and Yoshikazu Hayashi and Takuya Nishinakagawa and Mai Hazekawa and Shintaro Kawano and Seiji Nakamura and Manabu Nakashima",

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doi = "10.1016/j.job.2015.10.001",

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AU - Kawakubo-Yasukochi, Tomoyo

AU - Morioka, Masahiko

AU - Hayashi, Yoshikazu

AU - Nishinakagawa, Takuya

AU - Hazekawa, Mai

AU - Kawano, Shintaro

AU - Nakamura, Seiji

AU - Nakashima, Manabu

PY - 2016/2/1

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N2 - Emerging evidence indicates that cancer-derived exosomes increase the tumorigenic potential of tumor cells by reprogramming the cells associated with the tumor microenvironment. Our aim was to examine the cross talk via exosomes between two oral squamous cell carcinoma (OSCC) clones from the same patient. Our data showed that exosomes derived from highly metastatic SQUU-B cells conferred metastatic ability to nonmetastatic SQUU-A cells and subsequently reduced mRNA expression of cytokeratin 13, which is strongly linked to malignant transformation of OSCCs. The results suggest that multiple cell clones secrete their unique exosomes within the malignant tumor mass, which mediate paracrine interactions with other cell clones and affect clinical prognosis.

AB - Emerging evidence indicates that cancer-derived exosomes increase the tumorigenic potential of tumor cells by reprogramming the cells associated with the tumor microenvironment. Our aim was to examine the cross talk via exosomes between two oral squamous cell carcinoma (OSCC) clones from the same patient. Our data showed that exosomes derived from highly metastatic SQUU-B cells conferred metastatic ability to nonmetastatic SQUU-A cells and subsequently reduced mRNA expression of cytokeratin 13, which is strongly linked to malignant transformation of OSCCs. The results suggest that multiple cell clones secrete their unique exosomes within the malignant tumor mass, which mediate paracrine interactions with other cell clones and affect clinical prognosis.

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The SQUU-B cell line spreads its metastatic properties to nonmetastatic clone SQUU-A from the same patient through exosomes

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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