The suppressive effect of tecogalan sodium on in vitro angiogenesis via the periendothelial proteolytic activities

Hiroshi Yoshikawa; Tatsuro Ishibashi; Yasuaki Hata; Hajime Inomata; Katsuo Sueishi

doi:10.1159/000055624

The suppressive effect of tecogalan sodium on in vitro angiogenesis via the periendothelial proteolytic activities

Hiroshi Yoshikawa, Tatsuro Ishibashi, Yasuaki Hata, Hajime Inomata, Katsuo Sueishi

Kyushu University Hospital

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

The exact mechanisms of the angiostatic effect by tecogalan sodium (TS) remain unclear. We examined the effects of TS on in vitro angiogenic activity, proteolytic activity and proliferation of retinal vascular endothelial cells (RECs). TS markedly inhibited the in vitro angiogenic activity of RECs although the growth inhibition of RECs was small. TS apparently decreased the cell-associated urokinase-type plasminogen activator (uPA) activity and matrix metalloprotease 1 (MMP-1) activity even in the presence of anti-bFGF IgG. Thus, the suppression of the periendothelial matrix-degrading activities related to uPA and MMP-1 is suggested to be another possible mechanism of the antiangiogenic effect of TS, besides its prevention of bFGF REC binding which has previously been reported. Copyright (C) 2000 S. Karger AG, Basel.

Original language	English
Pages (from-to)	261-269
Number of pages	9
Journal	Ophthalmic Research
Volume	32
Issue number	6
DOIs	https://doi.org/10.1159/000055624
Publication status	Published - Jan 1 2000

All Science Journal Classification (ASJC) codes

Ophthalmology
Sensory Systems
Cellular and Molecular Neuroscience

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title = "The suppressive effect of tecogalan sodium on in vitro angiogenesis via the periendothelial proteolytic activities",

abstract = "The exact mechanisms of the angiostatic effect by tecogalan sodium (TS) remain unclear. We examined the effects of TS on in vitro angiogenic activity, proteolytic activity and proliferation of retinal vascular endothelial cells (RECs). TS markedly inhibited the in vitro angiogenic activity of RECs although the growth inhibition of RECs was small. TS apparently decreased the cell-associated urokinase-type plasminogen activator (uPA) activity and matrix metalloprotease 1 (MMP-1) activity even in the presence of anti-bFGF IgG. Thus, the suppression of the periendothelial matrix-degrading activities related to uPA and MMP-1 is suggested to be another possible mechanism of the antiangiogenic effect of TS, besides its prevention of bFGF REC binding which has previously been reported. Copyright (C) 2000 S. Karger AG, Basel.",

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T1 - The suppressive effect of tecogalan sodium on in vitro angiogenesis via the periendothelial proteolytic activities

AU - Yoshikawa, Hiroshi

AU - Ishibashi, Tatsuro

AU - Hata, Yasuaki

AU - Inomata, Hajime

AU - Sueishi, Katsuo

PY - 2000/1/1

Y1 - 2000/1/1

N2 - The exact mechanisms of the angiostatic effect by tecogalan sodium (TS) remain unclear. We examined the effects of TS on in vitro angiogenic activity, proteolytic activity and proliferation of retinal vascular endothelial cells (RECs). TS markedly inhibited the in vitro angiogenic activity of RECs although the growth inhibition of RECs was small. TS apparently decreased the cell-associated urokinase-type plasminogen activator (uPA) activity and matrix metalloprotease 1 (MMP-1) activity even in the presence of anti-bFGF IgG. Thus, the suppression of the periendothelial matrix-degrading activities related to uPA and MMP-1 is suggested to be another possible mechanism of the antiangiogenic effect of TS, besides its prevention of bFGF REC binding which has previously been reported. Copyright (C) 2000 S. Karger AG, Basel.

AB - The exact mechanisms of the angiostatic effect by tecogalan sodium (TS) remain unclear. We examined the effects of TS on in vitro angiogenic activity, proteolytic activity and proliferation of retinal vascular endothelial cells (RECs). TS markedly inhibited the in vitro angiogenic activity of RECs although the growth inhibition of RECs was small. TS apparently decreased the cell-associated urokinase-type plasminogen activator (uPA) activity and matrix metalloprotease 1 (MMP-1) activity even in the presence of anti-bFGF IgG. Thus, the suppression of the periendothelial matrix-degrading activities related to uPA and MMP-1 is suggested to be another possible mechanism of the antiangiogenic effect of TS, besides its prevention of bFGF REC binding which has previously been reported. Copyright (C) 2000 S. Karger AG, Basel.

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The suppressive effect of tecogalan sodium on in vitro angiogenesis via the periendothelial proteolytic activities

Abstract

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