The suppressive effect of tecogalan sodium on in vitro angiogenesis via the periendothelial proteolytic activities

Hiroshi Yoshikawa, Tatsuro Ishibashi, Yasuaki Hata, Hajime Inomata, Katsuo Sueishi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The exact mechanisms of the angiostatic effect by tecogalan sodium (TS) remain unclear. We examined the effects of TS on in vitro angiogenic activity, proteolytic activity and proliferation of retinal vascular endothelial cells (RECs). TS markedly inhibited the in vitro angiogenic activity of RECs although the growth inhibition of RECs was small. TS apparently decreased the cell-associated urokinase-type plasminogen activator (uPA) activity and matrix metalloprotease 1 (MMP-1) activity even in the presence of anti-bFGF IgG. Thus, the suppression of the periendothelial matrix-degrading activities related to uPA and MMP-1 is suggested to be another possible mechanism of the antiangiogenic effect of TS, besides its prevention of bFGF REC binding which has previously been reported. Copyright (C) 2000 S. Karger AG, Basel.

Original languageEnglish
Pages (from-to)261-269
Number of pages9
JournalOphthalmic Research
Volume32
Issue number6
DOIs
Publication statusPublished - Jan 1 2000

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Retinal Vessels
Endothelial Cells
Urokinase-Type Plasminogen Activator
Metalloproteases
In Vitro Techniques
tecogalan
Growth

All Science Journal Classification (ASJC) codes

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

The suppressive effect of tecogalan sodium on in vitro angiogenesis via the periendothelial proteolytic activities. / Yoshikawa, Hiroshi; Ishibashi, Tatsuro; Hata, Yasuaki; Inomata, Hajime; Sueishi, Katsuo.

In: Ophthalmic Research, Vol. 32, No. 6, 01.01.2000, p. 261-269.

Research output: Contribution to journalArticle

Yoshikawa, Hiroshi ; Ishibashi, Tatsuro ; Hata, Yasuaki ; Inomata, Hajime ; Sueishi, Katsuo. / The suppressive effect of tecogalan sodium on in vitro angiogenesis via the periendothelial proteolytic activities. In: Ophthalmic Research. 2000 ; Vol. 32, No. 6. pp. 261-269.
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