The T cell receptor β chain genes are located on chromosome 6 in mice and chromosome 7 in humans

Nicolette Caccia, Mitchell Kronenberg, Debra Saxe, Regina Haars, Gail A.P. Bruns, Joan Goverman, Marie Malissen, Hunt Willard, Yasunobu Yoshikai, Melvin Simon, Leroy Hood, Tak W. Mak

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    Abstract

    Homologous clones that encode the β chain of the T cell antigen receptor have been isolated recently from both murine and human cDNA libraries. These cDNA clones have been used in connection with interspecies hybrid cell lines to determine that the murine T cell receptor gene is located on chromosome 6 and the human gene on chromosome 7. In situ hybridization confirms these data and further localizes these genes to band B of chromosome 6 in the mouse and bands 7p13-21 in the human genome. The organization of the T cell antigen receptor Jβ gene segments and Cβ genes appears to be conserved, since very few intraspecies polymorphisms of restriction fragment length have been detected in either mouse or human DNA.

    Original languageEnglish
    Pages (from-to)1091-1099
    Number of pages9
    JournalCell
    Volume37
    Issue number3
    DOIs
    Publication statusPublished - Jul 1984

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    All Science Journal Classification (ASJC) codes

    • Biochemistry, Genetics and Molecular Biology(all)

    Cite this

    Caccia, N., Kronenberg, M., Saxe, D., Haars, R., Bruns, G. A. P., Goverman, J., ... Mak, T. W. (1984). The T cell receptor β chain genes are located on chromosome 6 in mice and chromosome 7 in humans. Cell, 37(3), 1091-1099. https://doi.org/10.1016/0092-8674(84)90443-4