WarfarinとS-1併用患者における血液凝固能異常の発現時期に関する検討

Translated title of the contribution: The Timing of Expression of Blood Coagulation Abnormality in Patients Treated with Warfarin and S-1 Concomitantly

山田 孝明, 渡邉 裕之, 矢野 貴久, 野中 敏治, 高田 敦史, 園田 正信, 窪田 敏夫, 江頭 伸昭, 大石 了三

Research output: Contribution to journalArticlepeer-review

Abstract

  Although S-1 is frequently used in cancer chemotherapy, the drug interaction with warfarin, an anticoagulant agent, is not fully paid attention. In the present study, we investigated retrospectively the timing of expression of blood coagulation abnormality in nine patients treated with warfarin and S-1 concomitantly. In five patients, the dose of warfarin was reduced or interrupted after concomitant use of S-1. The International Normalized Ratio (INR) was significantly increased after combination with S-1 compared with the former value. In all patients, the INR was increased in three weeks after combination with S-1. On the other hand, serum creatinine, aspartate aminotransferase, alanine aminotransferase or serum albumin was not different before and after combination with S-1. These results suggest that the careful monitoring of the blood coagulation ability is necessary in all patients receiving warfarin and S-1 concomitantly.<br>
Translated title of the contributionThe Timing of Expression of Blood Coagulation Abnormality in Patients Treated with Warfarin and S-1 Concomitantly
Original languageJapanese
Pages (from-to)955-960
Number of pages6
JournalYakugaku Zasshi
Volume130
Issue number7
DOIs
Publication statusPublished - 2010

Fingerprint Dive into the research topics of 'The Timing of Expression of Blood Coagulation Abnormality in Patients Treated with Warfarin and S-1 Concomitantly'. Together they form a unique fingerprint.

Cite this