The timing of the appearance of oral mucositis induced by concurrent chemoradiotherapy with S-1 for head and neck cancer

Hiroto Yonekita, Hisamitsu Takase, Kentaro Ogata, Koujiro Futagami, Satoshi Nomoto, Kengo Yoshimitsu, Takashi Nakagawa, Sohei Tokunaga

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Oral mucositis is a frequent adverse event in patients receiving concurrent chemoradiotherapy for head and neck cancer. Although the management of oral mucositis is essential to improve treatment completion rates, no detailed studies on the time of oral mucositis appearance have been reported. We conducted a retrospective study on the timing of the appearance of oral mucositis induced by concurrent chemoradiotherapy with S-1 for head and neck cancer. A total of 11 patients with head and neck cancer who received concurrent chemoradiotherapy with S-1 were examined. All patients developed oral mucositis within 13.8±5.6 days after the initiation of radiotherapy (20.4±8.1 Gy). In addition, the effects of pain-associated symptoms caused by oral mucositis on the patients' nutritional status, including reduction in caloric intake (24.4% ±31.1 %), weight loss (5.2%±5.2%), and duration of a regular diet (24.5±17.1 days), were observed and lasted until the completion of radiation therapy. The delineation of the timing of oral mucositis appearance has become a key motivator for the patients to perform oral care proactively to limit severity and serves as a necessary index for monitoring oral health and managing pain and nutrition.

Original languageEnglish
Pages (from-to)2571-2575
Number of pages5
JournalJapanese Journal of Cancer and Chemotherapy
Volume41
Issue number13
Publication statusPublished - Dec 1 2014

Fingerprint

Stomatitis
Chemoradiotherapy
Head and Neck Neoplasms
Radiotherapy
Pain
Oral Health
Energy Intake
Nutritional Status
Weight Loss
Retrospective Studies
Diet

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Yonekita, H., Takase, H., Ogata, K., Futagami, K., Nomoto, S., Yoshimitsu, K., ... Tokunaga, S. (2014). The timing of the appearance of oral mucositis induced by concurrent chemoradiotherapy with S-1 for head and neck cancer. Japanese Journal of Cancer and Chemotherapy, 41(13), 2571-2575.

The timing of the appearance of oral mucositis induced by concurrent chemoradiotherapy with S-1 for head and neck cancer. / Yonekita, Hiroto; Takase, Hisamitsu; Ogata, Kentaro; Futagami, Koujiro; Nomoto, Satoshi; Yoshimitsu, Kengo; Nakagawa, Takashi; Tokunaga, Sohei.

In: Japanese Journal of Cancer and Chemotherapy, Vol. 41, No. 13, 01.12.2014, p. 2571-2575.

Research output: Contribution to journalArticle

Yonekita, H, Takase, H, Ogata, K, Futagami, K, Nomoto, S, Yoshimitsu, K, Nakagawa, T & Tokunaga, S 2014, 'The timing of the appearance of oral mucositis induced by concurrent chemoradiotherapy with S-1 for head and neck cancer', Japanese Journal of Cancer and Chemotherapy, vol. 41, no. 13, pp. 2571-2575.
Yonekita, Hiroto ; Takase, Hisamitsu ; Ogata, Kentaro ; Futagami, Koujiro ; Nomoto, Satoshi ; Yoshimitsu, Kengo ; Nakagawa, Takashi ; Tokunaga, Sohei. / The timing of the appearance of oral mucositis induced by concurrent chemoradiotherapy with S-1 for head and neck cancer. In: Japanese Journal of Cancer and Chemotherapy. 2014 ; Vol. 41, No. 13. pp. 2571-2575.
@article{41b9d4fd495e401a82e2fd6a9e364555,
title = "The timing of the appearance of oral mucositis induced by concurrent chemoradiotherapy with S-1 for head and neck cancer",
abstract = "Oral mucositis is a frequent adverse event in patients receiving concurrent chemoradiotherapy for head and neck cancer. Although the management of oral mucositis is essential to improve treatment completion rates, no detailed studies on the time of oral mucositis appearance have been reported. We conducted a retrospective study on the timing of the appearance of oral mucositis induced by concurrent chemoradiotherapy with S-1 for head and neck cancer. A total of 11 patients with head and neck cancer who received concurrent chemoradiotherapy with S-1 were examined. All patients developed oral mucositis within 13.8±5.6 days after the initiation of radiotherapy (20.4±8.1 Gy). In addition, the effects of pain-associated symptoms caused by oral mucositis on the patients' nutritional status, including reduction in caloric intake (24.4{\%} ±31.1 {\%}), weight loss (5.2{\%}±5.2{\%}), and duration of a regular diet (24.5±17.1 days), were observed and lasted until the completion of radiation therapy. The delineation of the timing of oral mucositis appearance has become a key motivator for the patients to perform oral care proactively to limit severity and serves as a necessary index for monitoring oral health and managing pain and nutrition.",
author = "Hiroto Yonekita and Hisamitsu Takase and Kentaro Ogata and Koujiro Futagami and Satoshi Nomoto and Kengo Yoshimitsu and Takashi Nakagawa and Sohei Tokunaga",
year = "2014",
month = "12",
day = "1",
language = "English",
volume = "41",
pages = "2571--2575",
journal = "Japanese Journal of Cancer and Chemotherapy",
issn = "0385-0684",
publisher = "Japanese Journal of Cancer and Chemotherapy Publishers Inc.",
number = "13",

}

TY - JOUR

T1 - The timing of the appearance of oral mucositis induced by concurrent chemoradiotherapy with S-1 for head and neck cancer

AU - Yonekita, Hiroto

AU - Takase, Hisamitsu

AU - Ogata, Kentaro

AU - Futagami, Koujiro

AU - Nomoto, Satoshi

AU - Yoshimitsu, Kengo

AU - Nakagawa, Takashi

AU - Tokunaga, Sohei

PY - 2014/12/1

Y1 - 2014/12/1

N2 - Oral mucositis is a frequent adverse event in patients receiving concurrent chemoradiotherapy for head and neck cancer. Although the management of oral mucositis is essential to improve treatment completion rates, no detailed studies on the time of oral mucositis appearance have been reported. We conducted a retrospective study on the timing of the appearance of oral mucositis induced by concurrent chemoradiotherapy with S-1 for head and neck cancer. A total of 11 patients with head and neck cancer who received concurrent chemoradiotherapy with S-1 were examined. All patients developed oral mucositis within 13.8±5.6 days after the initiation of radiotherapy (20.4±8.1 Gy). In addition, the effects of pain-associated symptoms caused by oral mucositis on the patients' nutritional status, including reduction in caloric intake (24.4% ±31.1 %), weight loss (5.2%±5.2%), and duration of a regular diet (24.5±17.1 days), were observed and lasted until the completion of radiation therapy. The delineation of the timing of oral mucositis appearance has become a key motivator for the patients to perform oral care proactively to limit severity and serves as a necessary index for monitoring oral health and managing pain and nutrition.

AB - Oral mucositis is a frequent adverse event in patients receiving concurrent chemoradiotherapy for head and neck cancer. Although the management of oral mucositis is essential to improve treatment completion rates, no detailed studies on the time of oral mucositis appearance have been reported. We conducted a retrospective study on the timing of the appearance of oral mucositis induced by concurrent chemoradiotherapy with S-1 for head and neck cancer. A total of 11 patients with head and neck cancer who received concurrent chemoradiotherapy with S-1 were examined. All patients developed oral mucositis within 13.8±5.6 days after the initiation of radiotherapy (20.4±8.1 Gy). In addition, the effects of pain-associated symptoms caused by oral mucositis on the patients' nutritional status, including reduction in caloric intake (24.4% ±31.1 %), weight loss (5.2%±5.2%), and duration of a regular diet (24.5±17.1 days), were observed and lasted until the completion of radiation therapy. The delineation of the timing of oral mucositis appearance has become a key motivator for the patients to perform oral care proactively to limit severity and serves as a necessary index for monitoring oral health and managing pain and nutrition.

UR - http://www.scopus.com/inward/record.url?scp=84924908717&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84924908717&partnerID=8YFLogxK

M3 - Article

VL - 41

SP - 2571

EP - 2575

JO - Japanese Journal of Cancer and Chemotherapy

JF - Japanese Journal of Cancer and Chemotherapy

SN - 0385-0684

IS - 13

ER -