The transcription factor Apontic-like controls diverse colouration pattern in caterpillars

Shinichi Yoda, Junichi Yamaguchi, Kazuei Mita, Kimiko Yamamoto, Yutaka Banno, Toshiya Ando, Takaaki Daimon, Haruhiko Fujiwara

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Genetic polymorphisms underlie the convergent and divergent evolution of various phenotypes. Diverse colour patterns on caterpillars, which are ecologically important, are good models for understanding the molecular backgrounds of phenotypic diversity. Here we show that a single evolutionarily conserved gene apontic-like (apt-like) encoding for a putative transcription factor accounts for the silkworm p locus, which causes at least 15 different larval markings involved in branch-like markings and eye-spot formation. The expression of apt-like and melanin synthesis genes are upregulated in association with pigmented areas of marking mutants Striped (p S) and normal (+ p) but not in the non-marking allele plain (p). Functional analyses, ectopic expression, RNAi and TALEN, demonstrate that apt-like causes melanin pigmentation in a cell-Autonomous manner. These results suggest that variation in p alleles is caused by the differential expression of the gene apt-like which induces targeted elevation of gene expressions in the melanin synthesis pathway.

Original languageEnglish
Article number4936
JournalNature communications
Volume5
DOIs
Publication statusPublished - Jan 1 2014

Fingerprint

melanin
Melanins
genes
marking
Transcription Factors
Genes
color
silkworms
Alleles
Gene Expression
phenotype
Molecular Models
Bombyx
causes
gene expression
polymorphism
Pigmentation
Genetic Polymorphisms
synthesis
loci

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

The transcription factor Apontic-like controls diverse colouration pattern in caterpillars. / Yoda, Shinichi; Yamaguchi, Junichi; Mita, Kazuei; Yamamoto, Kimiko; Banno, Yutaka; Ando, Toshiya; Daimon, Takaaki; Fujiwara, Haruhiko.

In: Nature communications, Vol. 5, 4936, 01.01.2014.

Research output: Contribution to journalArticle

Yoda, S, Yamaguchi, J, Mita, K, Yamamoto, K, Banno, Y, Ando, T, Daimon, T & Fujiwara, H 2014, 'The transcription factor Apontic-like controls diverse colouration pattern in caterpillars', Nature communications, vol. 5, 4936. https://doi.org/10.1038/ncomms5936
Yoda, Shinichi ; Yamaguchi, Junichi ; Mita, Kazuei ; Yamamoto, Kimiko ; Banno, Yutaka ; Ando, Toshiya ; Daimon, Takaaki ; Fujiwara, Haruhiko. / The transcription factor Apontic-like controls diverse colouration pattern in caterpillars. In: Nature communications. 2014 ; Vol. 5.
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