The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells

Yasutaka Motomura, Hiroshi Kitamura, Atsushi Hijikata, Yuko Matsunaga, Koichiro Matsumoto, Hiromasa Inoue, Koji Atarashi, Shohei Hori, Hiroshi Watarai, Jinfang Zhu, Masaru Taniguchi, Masato Kubo

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Abstract

The immunoregulatory cytokine interleukin 10 (IL-10) is expressed mainly by T helper type 2 (TH 2) cells but also by TH 1 cells during chronic infection. Here we observed plasticity in the expression of IL-10 and IL-13 after chronic TH 1 stimulation; furthermore, the expression of Il10 and Il13 was regulated by the transcription factor E4BP4. Chronically stimulated E4BP4-deficient (Nfil3 -/-; called 'E4bp4 -/- ' here) TH 1 cells, regulatory T cells (T reg cells) and natural killer T cells (NKT cells) had attenuated expression of IL-10 and IL-13. Enforced expression of E4bp4 initiated the production of IL-10 and IL-13 by conventional TH 1 cells. E4bp4-/- TH 2 cells showed impairment of IL-10 production with no effect on IL-13. Our results indicate that E4BP4 has multiple functions in controlling the plasticity of IL-13 in TH 1 cells and IL-10 in TH 1 cells, TH 2 cells, Treg cells and NKT cells.

Original languageEnglish
Pages (from-to)450-459
Number of pages10
JournalNature Immunology
Volume12
Issue number5
DOIs
Publication statusPublished - May 1 2011

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Interleukin-13
Interleukin-10
Th1 Cells
Transcription Factors
T-Lymphocytes
Th2 Cells
Natural Killer T-Cells
Regulatory T-Lymphocytes
Cytokines
Infection

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

Motomura, Y., Kitamura, H., Hijikata, A., Matsunaga, Y., Matsumoto, K., Inoue, H., ... Kubo, M. (2011). The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells. Nature Immunology, 12(5), 450-459. https://doi.org/10.1038/ni.2020

The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells. / Motomura, Yasutaka; Kitamura, Hiroshi; Hijikata, Atsushi; Matsunaga, Yuko; Matsumoto, Koichiro; Inoue, Hiromasa; Atarashi, Koji; Hori, Shohei; Watarai, Hiroshi; Zhu, Jinfang; Taniguchi, Masaru; Kubo, Masato.

In: Nature Immunology, Vol. 12, No. 5, 01.05.2011, p. 450-459.

Research output: Contribution to journalArticle

Motomura, Y, Kitamura, H, Hijikata, A, Matsunaga, Y, Matsumoto, K, Inoue, H, Atarashi, K, Hori, S, Watarai, H, Zhu, J, Taniguchi, M & Kubo, M 2011, 'The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells', Nature Immunology, vol. 12, no. 5, pp. 450-459. https://doi.org/10.1038/ni.2020
Motomura, Yasutaka ; Kitamura, Hiroshi ; Hijikata, Atsushi ; Matsunaga, Yuko ; Matsumoto, Koichiro ; Inoue, Hiromasa ; Atarashi, Koji ; Hori, Shohei ; Watarai, Hiroshi ; Zhu, Jinfang ; Taniguchi, Masaru ; Kubo, Masato. / The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells. In: Nature Immunology. 2011 ; Vol. 12, No. 5. pp. 450-459.
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