The transcription factor Pokemon: A new key player in cancer pathogenesis

Takahiro Maeda, Robin M. Hobbs, Pier Paolo Pandolfi

Research output: Contribution to journalReview article

80 Citations (Scopus)

Abstract

Learning how critical cell regulatory pathways are controlled may lead to new opportunities for cancer treatment. We recently identified the transcription factor Pokemon as a central regulator of the important tumor suppressor ARF. Pokemon is overexpressed in multiple human cancers and cells lacking Pokemon are refractory to oncogenic transformation. These findings suggest that Pokemon may offer an effective new target for cancer therapeutics.

Original languageEnglish
Pages (from-to)8575-8578
Number of pages4
JournalCancer Research
Volume65
Issue number19
DOIs
Publication statusPublished - Oct 1 2005
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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