Abstract
Learning how critical cell regulatory pathways are controlled may lead to new opportunities for cancer treatment. We recently identified the transcription factor Pokemon as a central regulator of the important tumor suppressor ARF. Pokemon is overexpressed in multiple human cancers and cells lacking Pokemon are refractory to oncogenic transformation. These findings suggest that Pokemon may offer an effective new target for cancer therapeutics.
| Original language | English |
|---|---|
| Pages (from-to) | 8575-8578 |
| Number of pages | 4 |
| Journal | Cancer Research |
| Volume | 65 |
| Issue number | 19 |
| DOIs | |
| Publication status | Published - Oct 1 2005 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Cancer Research
- Oncology
Cite this
The transcription factor Pokemon : A new key player in cancer pathogenesis. / Maeda, Takahiro; Hobbs, Robin M.; Pandolfi, Pier Paolo.
In: Cancer Research, Vol. 65, No. 19, 01.10.2005, p. 8575-8578.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - The transcription factor Pokemon
T2 - A new key player in cancer pathogenesis
AU - Maeda, Takahiro
AU - Hobbs, Robin M.
AU - Pandolfi, Pier Paolo
PY - 2005/10/1
Y1 - 2005/10/1
N2 - Learning how critical cell regulatory pathways are controlled may lead to new opportunities for cancer treatment. We recently identified the transcription factor Pokemon as a central regulator of the important tumor suppressor ARF. Pokemon is overexpressed in multiple human cancers and cells lacking Pokemon are refractory to oncogenic transformation. These findings suggest that Pokemon may offer an effective new target for cancer therapeutics.
AB - Learning how critical cell regulatory pathways are controlled may lead to new opportunities for cancer treatment. We recently identified the transcription factor Pokemon as a central regulator of the important tumor suppressor ARF. Pokemon is overexpressed in multiple human cancers and cells lacking Pokemon are refractory to oncogenic transformation. These findings suggest that Pokemon may offer an effective new target for cancer therapeutics.
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U2 - 10.1158/0008-5472.CAN-05-1055
DO - 10.1158/0008-5472.CAN-05-1055
M3 - Review article
VL - 65
SP - 8575
EP - 8578
JO - Journal of Cancer Research
JF - Journal of Cancer Research
SN - 0099-7013
IS - 19
ER -