TY - JOUR
T1 - The transcription factor Pokemon
T2 - A new key player in cancer pathogenesis
AU - Maeda, Takahiro
AU - Hobbs, Robin M.
AU - Pandolfi, Pier Paolo
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2005/10/1
Y1 - 2005/10/1
N2 - Learning how critical cell regulatory pathways are controlled may lead to new opportunities for cancer treatment. We recently identified the transcription factor Pokemon as a central regulator of the important tumor suppressor ARF. Pokemon is overexpressed in multiple human cancers and cells lacking Pokemon are refractory to oncogenic transformation. These findings suggest that Pokemon may offer an effective new target for cancer therapeutics.
AB - Learning how critical cell regulatory pathways are controlled may lead to new opportunities for cancer treatment. We recently identified the transcription factor Pokemon as a central regulator of the important tumor suppressor ARF. Pokemon is overexpressed in multiple human cancers and cells lacking Pokemon are refractory to oncogenic transformation. These findings suggest that Pokemon may offer an effective new target for cancer therapeutics.
UR - http://www.scopus.com/inward/record.url?scp=25444476684&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=25444476684&partnerID=8YFLogxK
U2 - 10.1158/0008-5472.CAN-05-1055
DO - 10.1158/0008-5472.CAN-05-1055
M3 - Review article
C2 - 16204018
AN - SCOPUS:25444476684
VL - 65
SP - 8575
EP - 8578
JO - Cancer Research
JF - Cancer Research
SN - 0008-5472
IS - 19
ER -