The transDSL ligase ribozyme can utilize various forms of modules to clamp its substrate and enzyme units

Junya Ishikawa, Nana Isomoto, Yuki Fujita, Hiroyuki Furuta, Yoshiya Ikawa

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

TransDSL is an RNA ligase ribozyme whose enzyme unit joins two RNA fragments constituting a substrate. The enzyme unit recognizes the substrate by means of two clamp modules. We constructed active variants by replacing the original clamp module with various types of interactions. Such flexible modularity would be advantageous in the application of this ribozyme in nanobiotechnology.

Original languageEnglish
Pages (from-to)872-874
Number of pages3
JournalBioscience, Biotechnology and Biochemistry
Volume74
Issue number4
DOIs
Publication statusPublished - May 3 2010

Fingerprint

Catalytic RNA
Clamping devices
Ligases
Nanobiotechnology
RNA
Substrates
Enzymes

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

Cite this

The transDSL ligase ribozyme can utilize various forms of modules to clamp its substrate and enzyme units. / Ishikawa, Junya; Isomoto, Nana; Fujita, Yuki; Furuta, Hiroyuki; Ikawa, Yoshiya.

In: Bioscience, Biotechnology and Biochemistry, Vol. 74, No. 4, 03.05.2010, p. 872-874.

Research output: Contribution to journalArticle

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