The transDSL ligase ribozyme can utilize various forms of modules to clamp its substrate and enzyme units

Junya Ishikawa, Nana Isomoto, Yuki Fujita, Hiroyuki Furuta, Yoshiya Ikawa

Research output: Contribution to journalArticle

2 Citations (Scopus)


TransDSL is an RNA ligase ribozyme whose enzyme unit joins two RNA fragments constituting a substrate. The enzyme unit recognizes the substrate by means of two clamp modules. We constructed active variants by replacing the original clamp module with various types of interactions. Such flexible modularity would be advantageous in the application of this ribozyme in nanobiotechnology.

Original languageEnglish
Pages (from-to)872-874
Number of pages3
JournalBioscience, Biotechnology and Biochemistry
Issue number4
Publication statusPublished - May 3 2010


All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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