Abstract
We evaluated the usefulness of fluorine-18-fluoro-2-deoxy-D-glucose positron emission tomography (FDG PET) in the detection of mediastinal lymph node metastases in patients with non-small cell lung cancer and then compared the findings with the results of X-ray CT by region based on the histological diagnoses. We examined 29 patients with non-small cell lung cancer. One hundred and thirty-two mediastinal lymph nodes were surgically removed and the histological diagnoses were confirmed. FDG PET images, including 146 mediastinal regions, were visually analysed and the mediastinal lymph nodes were scored as positive when the FDG uptake was higher than that in the other mediastinal structures. On the X-ray CT scans, any mediastinal lymph nodes with a diameter of 10 mm or larger were scored as positive. All three examinations were successfully performed on 71 regions. For FDG PET, we found a sensitivity of 76%, a specificity of 98% and an accuracy of 93%. On the other hand, for X-ray CT a sensitivity of 65%, a specificity of 87% and an accuracy of 82% were observed. A significant difference was observed in respect of both specificity and accuracy (P < 0.05). Based on the above findings, FDG PET is suggested to be superior to X-ray CT when used for the detection of mediastinal lymph node metastases in patients with non-small cell lung cancer.
| Original language | English |
|---|---|
| Pages (from-to) | 741-747 |
| Number of pages | 7 |
| Journal | European Journal of Nuclear Medicine |
| Volume | 23 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - Jul 30 1996 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Radiology Nuclear Medicine and imaging
Cite this
The usefulness of FDG positron emission tomography for the detection of mediastinal lymph node metastases in patients with non-small cell lung cancer : A comparative study with X-ray computed tomography. / Sasaki, Masayuki; Lchiya, Yuichi; Kuwabara, Yasuo; Akashi, Yuko; Yoshida, Tsuyoshi; Fukumura, Toshimitsu; Murayama, Sadayuki; Ishida, Teruyoshi; Sugio, Kenji; Masuda, Kouji.
In: European Journal of Nuclear Medicine, Vol. 23, No. 7, 30.07.1996, p. 741-747.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The usefulness of FDG positron emission tomography for the detection of mediastinal lymph node metastases in patients with non-small cell lung cancer
T2 - A comparative study with X-ray computed tomography
AU - Sasaki, Masayuki
AU - Lchiya, Yuichi
AU - Kuwabara, Yasuo
AU - Akashi, Yuko
AU - Yoshida, Tsuyoshi
AU - Fukumura, Toshimitsu
AU - Murayama, Sadayuki
AU - Ishida, Teruyoshi
AU - Sugio, Kenji
AU - Masuda, Kouji
PY - 1996/7/30
Y1 - 1996/7/30
N2 - We evaluated the usefulness of fluorine-18-fluoro-2-deoxy-D-glucose positron emission tomography (FDG PET) in the detection of mediastinal lymph node metastases in patients with non-small cell lung cancer and then compared the findings with the results of X-ray CT by region based on the histological diagnoses. We examined 29 patients with non-small cell lung cancer. One hundred and thirty-two mediastinal lymph nodes were surgically removed and the histological diagnoses were confirmed. FDG PET images, including 146 mediastinal regions, were visually analysed and the mediastinal lymph nodes were scored as positive when the FDG uptake was higher than that in the other mediastinal structures. On the X-ray CT scans, any mediastinal lymph nodes with a diameter of 10 mm or larger were scored as positive. All three examinations were successfully performed on 71 regions. For FDG PET, we found a sensitivity of 76%, a specificity of 98% and an accuracy of 93%. On the other hand, for X-ray CT a sensitivity of 65%, a specificity of 87% and an accuracy of 82% were observed. A significant difference was observed in respect of both specificity and accuracy (P < 0.05). Based on the above findings, FDG PET is suggested to be superior to X-ray CT when used for the detection of mediastinal lymph node metastases in patients with non-small cell lung cancer.
AB - We evaluated the usefulness of fluorine-18-fluoro-2-deoxy-D-glucose positron emission tomography (FDG PET) in the detection of mediastinal lymph node metastases in patients with non-small cell lung cancer and then compared the findings with the results of X-ray CT by region based on the histological diagnoses. We examined 29 patients with non-small cell lung cancer. One hundred and thirty-two mediastinal lymph nodes were surgically removed and the histological diagnoses were confirmed. FDG PET images, including 146 mediastinal regions, were visually analysed and the mediastinal lymph nodes were scored as positive when the FDG uptake was higher than that in the other mediastinal structures. On the X-ray CT scans, any mediastinal lymph nodes with a diameter of 10 mm or larger were scored as positive. All three examinations were successfully performed on 71 regions. For FDG PET, we found a sensitivity of 76%, a specificity of 98% and an accuracy of 93%. On the other hand, for X-ray CT a sensitivity of 65%, a specificity of 87% and an accuracy of 82% were observed. A significant difference was observed in respect of both specificity and accuracy (P < 0.05). Based on the above findings, FDG PET is suggested to be superior to X-ray CT when used for the detection of mediastinal lymph node metastases in patients with non-small cell lung cancer.
UR - http://www.scopus.com/inward/record.url?scp=8944259910&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=8944259910&partnerID=8YFLogxK
U2 - 10.1007/BF00843701
DO - 10.1007/BF00843701
M3 - Article
C2 - 8662111
AN - SCOPUS:8944259910
VL - 23
SP - 741
EP - 747
JO - European Journal of Nuclear Medicine and Molecular Imaging
JF - European Journal of Nuclear Medicine and Molecular Imaging
SN - 1619-7070
IS - 7
ER -